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Tag: "progression" at biology news

New push for public health, AIDS spending at African Union summit

...ail of antiretroviral (ARV) drugs that inhibit the progression of their disease, which has no known cure. But demand for free drugs vastly outstrips their supply, the cost of the drugs - at some $US600 annually for the rest of a patient's life, an impossible dream on the continent. Generic versions of the drug...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...ing me, expect epigenetic differences to influence progression -- whether a tumor would grow slowly or quickly, or whether it would spread," says Feinberg. "But, in this case, our results show that loss of imprinting of IGF2 contributes to colon cancer's development in the mice. It doesn't cause tumors directly,...

Priming embryonic stem cells to fulfill their promise

...were allowed to grow, the researchers assayedtheir progression into liver cells. "We looked at all the combinationsat once," said Bhatia. "Nobody has done this combinatorial approachbefore."Bhatia, Chien, and Flaim reported that either collagen-1 or fibronectinhad strongly positive effects on the differentiation...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...e thought that clearing the plaques would halt the progression of thedamage--stop the development of new swellings," says Brendza. "But whatwe saw was much more striking: in just three days, there were 20 to 25percent reductions in the number or size of the existing swellings."The nerve cells' rapid ability to r...

Key molecule in plant photo-protection identified

...e thought that clearing the plaques would halt the progression of thedamage--stop the development of new swellings," says Brendza. "But whatwe saw was much more striking: in just three days, there were 20 to 25percent reductions in the number or size of the existing swellings."The nerve cells' rapid ability to r...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

...ia). "Previous theories about the development and progression of chronic lymphocytic leukemia require revision. With new molecular and protein markers now identified, patients with features that portend poor outcomes may soon be treated earlier and more effectively," said Dr. Chiorazzi. "Once these new prognos...

Breakthrough Microarray-based Technology for the Study of Cancer

...anding these changes is key tounderstanding cancer progression as well as developing possibletherapies and progno...t in cells are important events in the genesis and progression ofcancer," said Michael Bittner of the Translational Genomics ResearchInstitute. "Agilent has now ta...

Dinosaur DNA? New Patent Covers Degraded DNA recovery

...s Dr. Ensley. This patent is part of a scientific progression that began in 1989 when DNA was recovered from 12 samples of ancient organic remains, ranging in age from 4 to 13,000 years. The remains included several Egyptian mummies and two extinct species -- the marsupial wolf and ground sloth. Plant DNA up to...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...argeting of a well-known gene involved with cancer progression will have profound implications as we continue to focus on the causes of tumor development," said Richard L. Edelson, M.D., director of Yale Cancer Center. Other Yale researchers were Steven M. Johnson, Helge Grosshans and Kristy L. Reinert; collabo...

Gene vaccine for Alzheimer's disease shows promising results

...bility of using aprotein-based vaccine to slow the progression of the disease in itsearly stages. UT Southwestern... vaccination would be astep forward in slowing the progression of dementia.From the mouse studies and in previous clinical trials of patients withAlzheimer's disea...

Scientists identify molecular events that drive cell senescence

...bility of using aprotein-based vaccine to slow the progression of the disease in itsearly stages. UT Southwestern... vaccination would be astep forward in slowing the progression of dementia.From the mouse studies and in previous clinical trials of patients withAlzheimer's disea...

The very unexpected life and death of a leukemic cell

...they become abnormal and malignant (leukemic). The progression of the disease is slow and there has been a lack o...ch CLL cells are born and the clinical activity or progression of the disease in a patient. The disease activity may vary over time and this may be the result of f...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...molecular events that result in the initiation and progression of these tumors. It has been established that interfering with the function of one gene, called Adenomatous Polyposis Coli (APC) has a profound effect on the cells lining the innermost layer of the colon (called the epithelium) and causes them to los...

Use of PET can reduce, may eliminate more strenuous drug development trials with animals

...to monitor the effects of interventions on disease progression and outcome. Crucial information can be obtained noninvasively, repeatedly and quantitatively in the same animal, he said. With small animal imaging, one can very rapidly evaluate new radiopharmaceuticals using a limited number of animals and possibl...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...more closely resemble certain types of skin cancer progression than skin development, a mechanistic understanding of hair follicle development promises to shed light on how skin cancer develops as well. ...

Norovirus, AIDS vaccine and Hepatitis Virus

...to prevent HIV infection, it could protect against progression to full-blown AIDS. Researchers from Kansas report their findings in the March 2005 issue of the Journal of Virology. Developing a vaccine to protect against HIV in attempt to gain control of the AIDS pandemic is a top priority for researchers throu...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...LS), substantially delaying both the onset and the progression rate of the fatal motor neuron disease. Their resu...ng glial cells, and both the onset and the rate of progression of the disease in the treated mice were substantially reduced. In addition, the mice showed a signif...

Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells

...al nervous systems, said Kurtzberg. Thus, disease progression stabilizes about 2 to 4 months earlier in patients who receive cord blood compared to those who receive adult bone marrow, and huge developmental milestones occur during that period of infancy, said Kurtzberg. The ease of obtaining cord blood also m...

Youth With HIV Take More Risks After New Meds Introduced

...age, these youth are being identified later in the progression of the disease. Therefore, it is also likely that they were infected at a younger age," Lightfoot says. In the 1999-2000 group, only 53 percent of the teens were on HAART drug therapy. Lightfoot says it's "unclear" why more teens are not taking HAA...

New understanding of DNA repair may pave way to cancer treatments

... ATF2 has an important role in the development and progression of melanoma tumors. Inhibition of ATF2 was found to sensitize melanoma to various treatments, both in tissue culture and in animal models. "Melanoma is usually resistant to chemotherapy, but we found that by inhibiting ATF2, it became more sensitive...

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