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Tag: "programmed" at biology news

Unchecked DNA replication drives earliest steps toward cancer

...es, p53 may even force the cell into apoptosis, or programmed death, as a way to protect against the cell developing into a tumor. If the mutations occur in p53 itself, however, or the p53 pathway is unable to completely halt the process, further mutations will occur, leading the cell to become cancerous, with...

Turning viruses into allies against cancer

...n among these cells, probably through apoptosis or programmed cell death. When the modified virus was injected directly into human liver cancer cells grafted onto laboratory mice, scientists observed significant prolongation of life; complete regression was achieved in up to one-third of the treated mice. Dur...

New understanding of DNA repair may pave way to cancer treatments

...expression of proteins that control cell cycle and programmed cell death is well established. The current study ...rstanding its role in regulation of cell cycle and programmed cell death. These studies evolved from the finding that ATF2 has an important role in the developmen...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

...trophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues called phagocytes. Although the specific mechanisms that regulate the proper ratios of neutrophil production and...

Flocking together: Study shows how animal groups find their way

...ormation about where to go. First, the researchers programmed their simulated animals with a basic urge to stay ...tray from their group. Second, a few animals were programmed to have a preferred direction, as if aware of a food source or other valued destination. These anima...

Programmable cells: Engineer turns bacteria into living computers

...y were tiny computers, engineers at Princeton have programmed bacteria to communicate with each other and produc...echnology, Weiss and graduate student Subhayu Basu programmed E. coli bacteria to emit red or green fluorescent light in response to a signal emitted from another...

Antibiotic might fight HIV-induced neurological problems

...trigger a series of events that result in a cell's programmed death, called apoptosis. Only one of the five treated monkeys showed any signs of encephalitis, and that monkey's condition was deemed mild by a set of standard measures. After the same amount of time -- 84 days after infection -- five of the six un...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...f antibodies that a patient's own immune system is programmed to destroy. The Duke team discovered that certain broadly protective antibodies, which recognize and latch onto the HIV protein gp41, resemble antibodies made in autoimmune diseases. In most people, the immune system destroys these types of antibodi...

UCSD team discovers specialized, rare heart stem cells in newborns

...iac progenitor cells are stem cells that have been programmed to form heart muscle during fetal growth. Until th...i, Ph.D., IMM member, explained that the cells are programmed to become spontaneously beating cardiac muscle cells simply by exposure to other neighboring heart c...

The Bacteria's guide to survival

...espond to a bacterial infection with apoptosis, or programmed cell death. For bacteria that pass directly from host to host, this can pose a problem. If the bacteria are highly virulent and induce too much cell death, they could take down their host before they're able to jump ship, thus hurting the bacteria's ...

White blood cell waste disposal system plays critical regulatory role

...trophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues called phagocytes. Although the specific mechanisms that regulate the proper ratios of neutrophil production and...

The very unexpected life and death of a leukemic cell

...hers had been unable to find any problems with the programmed cell death machinery in CLL cells. This was a hint that perhaps the leukemia cells were not immortal, a hypothesis tested by Nicholas Chiorazzi and colleagues in a paper appearing online on February 10 in advance of publication in the March 1 print e...

New Mixing Method for Microchip-Sized Labs

...critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and fee...

Genetic Variation Visualization - From EMBL

...critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and fee...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

...critical growth factor receptors and isinvolved in programmed cell death, is aberrant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and fee...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

...id Dr.Larry Lok, a mathematician who conceived and programmed Moleculizer."Its parallel simplifications in simulation setup and output providedata in a way that is meaningful and useful to biological researchers."Moleculizer was developed in the context of MSI's "Alpha Project", anambitious experimental and com...

Critical role in programmed cell death identified

...e animal systems to humans. In spite of its name, programmed cell death, or apoptosis, is essential for life; i...inducing fragmentation provokes cell death. "This programmed cell death is so important and the more players we know that are involved, the more potential target...

U-M scientists find genes that control growth of common skin cancer

...umor cells stopped growing and wereeliminated by a programmed cell death process. These results areconsistent with previous work from other labs studying differentHh-associated tumors, “but we were very surprised to see that sometumor cells persisted after shutting down Gli2 expression,?saidDlugosz.In some of t...

Inexpensive, mass-produced genes core of synthetic biology advances at UH

...s very complex,even in simple organisms. By making programmed synthesis of geneseconomical, we can provide more ...ment at a fundamental level.Using current methods, programmed synthesis of a typical gene coststhousands of dollars. Thus, the prospect of creating the most primi...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...r to the baby, the baby's pancreatic cells will be programmed abnormally," said principal investigator Mary-Elizabeth Patti, M.D., Assistant Investigator in Joslin's Research Section on Cellular and Molecular Physiology and Assistant Professor of Medicine at Harvard Medical School. "The effect doesn't show up u...

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