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Tag: "programmed" at biology news

Restoring silenced suppressor gene kills lung-cancer cells

...self-destructed through a natural process known as programmed cell death, or apoptosis. The lung-cancer cells that lacked the WWOX gene, on the other hand, continued growing and increased in number nearly five- or six-fold. Next, the researchers took some of the lung-cancer cells to which they'd added working...

'Smart' nanoprobes light up disease

...undreds of times smaller than a human cell that is programmed to light up only when activated by specific proteases. Altered expression of particular proteases is a common hallmark of cancer, atherosclerosis, and many other diseases. In the September issue of the journal Biochemical and Biophysical Research Co...

Researchers learn how blood vessel cells cope with their pressure-packed job

...nto confluent layers, a piston-like "indenter" was programmed to repeatedly push into the underside of the membranes and retract. The 60-cycle-per-minute motion of the indenter simulated the stretching movements of a blood vessel in response to the rising-and-falling blood pressure produced by a beating heart. ...

New technology shows our ancestors ate…everything!

...ct. "You put the specimen in and the microscope is programmed to step down at fine intervals, perform its series of scans, and collect 3D coordinates for each data point," said Teaford. The result is like a map of the earth that shows mountains, valleys and plains in full relief, only at a microscopic scale. A...

Drugs from the deep blue

...ium is also a key signal in both fertilization and programmed cell death, he said. Pharmaceuticals that affect calcium channels range from drugs given to organ transplant patients to suppress the immune system, to treatments for high blood pressure and heart disease. Pessah's research group works with calcium ...

Protease inhibitors reach beyond HIV

...iciency that arises in HIV may be due to excessive programmed cell death of immune CD4 T cells. HIV protease inhibitors (PI) can block programmed cell death in virus-infected T cells in vitro, but have also been shown to induce programmed cell de...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

...ith PAH. Survivin is an inhibitor of apoptosis--or programmed cell death--which promotes cancer by suppressing the body's ability to limit excessive cell growth. Armed with this new information and using animal models, the researchers developed a nebulized and inhaled gene therapy to deliver an inactive Surviv...

Computer modeling reveals hidden conversations within cells

...informatics and experienced software engineer, who programmed the model. "It requires intuition built up over time, but it also requires someone like Alex, who can critically evaluate the scientific literature to decide what parameters need to be included in the model, and someone like Shannon who can take the...

How cell suicide protects plants from infection

...hat regulates the major immune response in plants, programmed cell death (PCD), according to a recent report in the journal Cell. To protect themselves from viruses, plants create a zone of dead cells around an infection site that prevents the infection from spreading. Savithramma Dinesh-Kumar, associate profe...

Elderly mice yield clues to the process of growing old

...mulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging proces... Prolla. "These experiments favor a major role for programmed cell death in aging." If true, the new insights may one day lead to opportunities to stave off old ...

Tagging pathogens with synthetic DNA 'barcodes'

..., only probes with a particular color code will be programmed to bind to that DNA. The results can be seen under a fluorescent light microscope using colored filters that pass only one color at a time. A signal in which the ratio of intensity of green light is four times that of red light, for example, identifi...

Compound from Chinese medicine shows promise in head and neck cancer

... induced the drug resistant tumor cells to undergo programmed cell death. "These cisplatin resistant cells are exquisitely sensitive to (-)-gossypol. We can induce cell death in 70 percent to 90 percent of cells. This is a very impressive induction of cell death. It's because we are targeting the pathways thes...

Nanoparticles carry cancer-killing drugs into tumor cells

...mors. An important mechanism of this regulation is programmed cell death, known as apoptosis. It causes the cont...versity of Vienna have now been able to prove that programmed cell death does not function in cells of certain tumors in the ovaries. Not because the starting sig...

Missing Receptor Molecule Causes Tumor Growth

...mors. An important mechanism of this regulation is programmed cell death, known as apoptosis. It causes the cont...versity of Vienna have now been able to prove that programmed cell death does not function in cells of certain tumors in the ovaries. Not because the starting sig...

Plankton can run, but can't hide from basking sharks

... water temperature and light levels. The tags were programmed to detach themselves from the sharks at a set time, float to the surface and then drift with the currents like a "electronic messages in bottles", before being washed up on beaches and found by the public. Sims found that while the sharks in deep wa...

New protein vital for immune response is found in surprise location

...g Wang and others, to play a role in apoptosis, or programmed cell death. The fact that MAVS is located in the membrane of mitochondria suggests it may play a role in coordinating cell death and immune response, Dr. Chen said. Secondly, many scientists believe that mitochondria originally evolved from bacteria...

Study: Well-known protein helps stem cells become secretory cells

... Andrew, "This suggests the salivary gland becomes programmed for secretion because all the components required to allow secretion to occur are 'turned on' very early in development." In order for any gene's instructions to be used to make a protein, the process of reading the instructions is jump-started by p...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

...sor protein, kicks in. It initiates the process of programmed cell death, or apoptosis, which directs the cell to commit suicide, permanently removing the damaged DNA from the organism. Since the p53 protein is able to trigger such drastic action as cellular suicide, the cells of the body must ensure that the ...

Researchers find gene that may be at root of potato blight

...Avr3a in a leaf cell, that plant cell died. "This programmed cell death is how the plant keeps the pathogen from spreading to other cells," Kamoun said. "Only a few cells die. It's one mechanism of defense some plants have." Until now, researchers knew little about P. infestans on the molecular level. By stu...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...ght Romesberg to the conclusion that mutation is a programmed stress response -- a survival mechanism. If the cell senses damage, and if the damage persists beyond its ability to repair it, the cell will turn on its mutation machinery and open the floodgates for evolution. Take the bacterium Escherichia coli f...

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