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Tag: "prognostic" at biology news

Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes

...r findings from the first-ever study examining the prognostic value of serum HBV DNA levels for patients with li...py. They also gathered other potentially important prognostic information, like age, sex, total bilirubin and presence of cirrhosis. Over the course of each patie...

Researchers use MRI to predict recovery after spinal cord injury

... whenever feasible as it provides information with prognostic value and serves to guide the clinician to optimize clinical care....

Researchers identify ovarian cancer biomarkers

...ssed they were in the tumor vasculature, were also prognostic of a patient's survival. We suspect when these genes are highly expressed it may be a sign of a tumor that's able to grow blood vessels more efficiently, and therefore is more aggressive. This may help us down the road in treatment decisions," says l...

Adding radiation decreases breast cancer recurrence

...presentation of older women in clinical trials and prognostic studies. Led by Ann M. Geiger, M.P.H., Ph.D., of Wake Forest University School of Medicine and formerly of Kaiser Permanente Southern California, researchers retrospectively followed 1,837 women over 65 for ten years who were treated with surgery...

Gene signature assesses breast cancer outcomes

...r, statistical analysis indicated that most of the prognostic information provided by traditional risk classifie... indicate that the gene signature adds independent prognostic information to that provided by a risk assessment based solely on clinico-pathologic factors." In a...

An advanced genetic diagnostic method for multiple myeloma

...c strategies for the detection of alterations with prognostic value. For this purpose, he has analyzed, by means of statistical methods, the cytogenetic changes in a group of patients with MM. This methodology has permitted the discovery of associations between specific chromosomal changes, and thus the descri...

Analysis of breast-cancer gene role offers promising target

...ogen activator system, is one of the breast-cancer prognostic factors that has the greatest level of evidence. "All the work has been on the protein and enzymatic activity and not amplification of the gene, which is a very reliable and easy-to-use diagnostic test called FISH," said Dr. Tripathy. "The other i...

Speeding discovery of the 'human cancer genome'

...he cancer's likelihood of spreading, although "any prognostic significance would require rigorous investigation and validation in appropriately designed prospective clinical trials." Taking a similar approach, Lowe's team identified two genes that can work together to encourage one form of liver cancer, call...

AIDS-related cognitive impairment exists in two separate forms

... proteins specific to cancer cells can be used for prognostic purposes, as can the newest type of biomarker, mcr...79 percent, Nielsen said. Such a test could offer prognostic value to clinicians who are unsure whether to treat their newly diagnosed patients with surgery alon...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

... proteins specific to cancer cells can be used for prognostic purposes, as can the newest type of biomarker, mcr...79 percent, Nielsen said. Such a test could offer prognostic value to clinicians who are unsure whether to treat their newly diagnosed patients with surgery alon...

Liver cancer linked to cellular repair pathway

...tages of liver cancer, as well as provide valuable prognostic information for patients," he said. Sicklick and colleagues also discovered a new Hedgehog pathway mutation in a patient with liver cancer that may lead to overactivation of Hedgehog and trigger abnormal cell growth, promoting cancer development. In...

Microarray technology for tailoring breast cancer therapy

...ing, tumour stage and age - which are all accepted prognostic markers for breast cancer. The present lack of criteria to help tailor breast cancer treatment to individual patients indicates a need to develop new techniques for better prediction of how patients will respond to adjuvant treatments. The researche...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

...urvivin in the pathogenesis of PAH, its value as a prognostic indicator, and its use as a target for new therapeutic strategies." Other authors include: Sean McMurtry, Pulmonary Hypertension Program; Stephen Archer, Canada Research Chair in Translational Cardiovascular Research; Dario Altieri, Department of Ca...

Genes linked to treatment resistance in children with leukemia

...ned the intensity of therapy. Patients with poorer prognostic factors ?130 children ?were assigned to a high-ris...gh-risk arm, the VDR FokI genotype was found to be prognostic for CNS relapse, especially when combined with a VDR intron 8 genotype. In the low-risk group, the T...

Biased reporting found in cancer prognostic studies

...ases may taint many published studies of so-called prognostic factors--biologic or genetic markers that may pred...chers have raced to discover and publish papers on prognostic factors for cancer and other diseases. For example, at least 116 published studies alone have focuse...

Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis

...ver pathologies. This HEPATOCHIP can be used as a prognostic tool for NASH-predisposed patients, to make possible more finely tuned diagnosis of this disease and allow healthcare professionals to tailor treatment to individual patients' needs. This chip also assess the efficacy of non-alcoholic steatohepatitis...

Scientists identify molecule that regulates well-known tumor suppressor

.... The authors go on to suggest that DJ-1 may be a prognostic marker for cancer patients and be useful as a target for development of future cancer therapeutics. Interestingly, DJ-1 may play a role in other disease states, as it has also been recently identified as a predictive diagnostic for early-onset, autos...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

...gful and scientifically valid research into better prognostic tests, new diagnostics, targeted therapies, predictive therapeutic strategies and potentially preventative modalities for patients" said IGC’s founder, Daniel Von Hoff, MD, FACP. IGC has established a uniform system for obtaining and processing tiss...

Mouse brain tumors mimic those in human genetic disorder

...to continueto hone in on more accurate diagnostic, prognostic and treatmentapproaches."Bajenaru ML, Garbow JR, Perry A, Hernandez MR, Gutmann DH. Naturalhistory of neurofibromatosis 1-associated optic nerve glioma formationin mice. Annals of Neurology, January 2005....

Breakthrough Microarray-based Technology for the Study of Cancer

...ession as well as developing possibletherapies and prognostic and diagnostic tools."Genomic alterations leading to changes in the number of gene copiespresent in cells are important events in the genesis and progression ofcancer," said Michael Bittner of the Translational Genomics ResearchInstitute. "Agilent ha...

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