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Tag: "prognosis" at biology news

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

...-70 may actually be the most reliable indicator of prognosis known to date. After discussing B lymphocytes -- the type of white blood cell that gives rise to CLL, the biology of leukemic lymphocytes and the clinical course of CLL as it relates to the biology, the authors then offer a unifying hypothesis for t...

Imaging Lymph Nodes with Nanoparticles

...s of thework up of patients for both prediction of prognosis and determinationof the most appropriate treatment. And an essential part of this workup is assessing whether or not there has been lymphatic spread. Currentmethods include surgical removal of nodes for examination and varioustypes of imaging, rangin...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...ccelerated Ras." Lung cancer currently has a poor prognosis with less than 15 percent of patients surviving five years. The lungs, however, are relatively accessible for inhalation of potential gene therapy agents. "While this is not likely to cure the cancer," said Slack, "after diagnosis, gene therapy with ...

Heart repair gets new muscle

...ing you are otherwise healthy, both will heal. The prognosis for a heart attack, on the other hand, is not so clear-cut. It has long been thought that cardiac cells (cardiomyocytes) lack the capacity for self-renewal and repair, impeding the chances of a full recovery from a heart attack. However, recent evid...

Scientists identify molecule that regulates well-known tumor suppressor

...ll, has important implications for determining the prognosis of some human cancers, and may prove to be a suitable target for cancer therapy. The phosphatidylinositol 3' kinase signaling pathway regulates cell growth and survival, and is inhibited by activity of the tumor suppressor PTEN. Research indicates t...

Turning viruses into allies against cancer

...e a variety of differing treatment approaches, its prognosis remains poor with a median survival of about 10 months following diagnosis. For this reason, scientists are anxious to find novel methods that could improve short- and long-term survival from this disease. "The attenuated vaccine strain of measles v...

'Smart drug' targets deadly brain cancer

... the Mayo Clinic/NCCTG Research This discouraging prognosis may change as a result of the rational foundation ...nths. For patients in whom the disease recurs, the prognosis is indeed dismal: there are no good treatment options. The Next Step Mayo Clinic researchers are c...

Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis

...erio), the first DNA chip concerning diagnosis and prognosis of non-alcoholic steatohepatitis (NASH), allowing the discrimination between normal, steatosis and NASH predisposed subjects. Non alcoholic steatohepatitis is a progressive disease of the liver of unknown etiology, characterized histologically by fa...

Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

...July 4. "GABA appears to be an indicator of a bad prognosis for these cancers," says Jeffrey I. Gordon, M.D., ...uction of these compounds were switched on in poor prognosis malignant metastatic tumors. "The mouse model was an important beginning point for our investigatio...

Emerald Spectre haunts Ontario's ash forests

... ash trees are already dead. "In my opinion, the prognosis does not look good in the Great Lakes region," says Dr. MacIsaac. "If containment doesn't work, we are going to see a repeat of Dutch elm disease, which wiped-out a dominant forest tree species from eastern North America." Dr. MacIsaac's paper on th...

Customized gene chip provides rapid detection of genetic changes in children's cancer

...mples for specific DNA changes that offer clues to prognosis in cases of neuroblastoma, a common form of children's cancer. Rather than covering the entire genome, the microarray focuses on suspect regions of chromosomes for signs of deleted genetic material known to play a role in the cancer. The investigato...

Microarray technology for tailoring breast cancer therapy

...tic signatures shown by 38 patients who had a poor prognosis - defined as relapse or death from any cause within 5 years. The remaining 121 patients were defined as the 'good prognosis' group. The researchers also used gene expression profiling to separate patients who did well with and without adjuvant therap...

Gene expression profile helps predict chemotherapy response in ovarian cancer patients

...OCPP] are a more powerful predictor of a patient's prognosis than either profile separately," says Cannistra. "...des us with valuable information about a patient's prognosis as this type of information cannot always be obtained from standard clinical features, such as tumor...

Combination therapy improves AIDS-related lymphoma outcome

...lated lymphomas" (ARL) and generally have a poorer prognosis than non-HIV-related lymphomas. Highly active antiretroviral therapy (HAART) revolutionized care of HIV-positive men and women. It not only improves laboratory indicators, such as increased CD-4 cells and reduced viral loads, but also significantly i...

Botox could help target resistant tumors for treatment

...iotherapy, and is a determining factor in the poor prognosis of tumors to cytotoxic treatments," said Gallez. "Botulinum toxin could lead to inhibition of contractions of tumor vessels, improve tumor perfusion and oxygenation, and enhance the response of tumors to radio- and chemotherapy." Botulinum toxin is ...

Single microRNA causes cancer in transgenic mouse

...lymphoma, and that its presence indicated a poorer prognosis in patients with breast and lung cancers. Croce, along with Dr. Stefan Costinean , a research associate, decided to isolate miR155 function by inserting the gene, along with an enhancer, to promote its expression, into fertilized eggs inside a preg...

Two NIH initiatives launch intensive efforts to find roots of common diseases

...eed to find out why a disease has such a different prognosis from one person to the next. Given the recent advances in biomedical research, this is the right time to take on this challenge." To determine how the environment, diet and physical activity contribute to illness, investments will be made in emergi...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

...s overexpression of SCF is associated with a worse prognosis and shorter survival in patients with glioblastomas. SCF expression is not directly linked to tumor cell proliferation but instead encourages the growth of blood vessels needed to support the expanding tumor. Importantly, these findings provide defin...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...the score is either very low or very high, but the prognosis for men who have scores in the mid-range is diffic...If the test is a strong enough predictor of a good prognosis at the stage of biopsy, men with indolent cancer may not need surgery or radiation at all," she said...

AIDS-related cognitive impairment exists in two separate forms

...the score is either very low or very high, but the prognosis for men who have scores in the mid-range is diffic...If the test is a strong enough predictor of a good prognosis at the stage of biopsy, men with indolent cancer may not need surgery or radiation at all," she said...

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