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Tag: "profiles" at biology news

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...set ofhuman tumor tissues. Overall, the expression profiles of portions ofindividual samples were highly compa...croarray analysis and the resultinggene expression profiles were analyzed and compared.Sample correlation within each lab was extremely high; microarray datafro...

Alcohol's effects on gene expression in the central nervous system

...id. "For the average reader, knowing which genetic profiles might contribute to excessive alcohol drinking could be used to identify risk factors that contribute to alcoholism and alcohol abuse, and could aid in the development of selective treatment strategies for different subgroups of alcoholics." McBride...

Agilent Technologies releases automated literature search tool for biology researchers

...ntegrating these interactions with gene expression profiles and other data. The platform supports gene functional annotations from Gene Ontology (GO) and KEGG databases, biological models from Systems Biology Markup Language (SBML), protein-protein interactions from BIND and TRANSFAC databases. Additional fea...

Asthma gene clusters identified

...The analysis revealed two distinct gene expression profiles in these groups of children, according to Gurjit K...ma. The amazing thing was that the gene expression profiles were consistent across patients, despite the likely differences with respect to the cause of asthma,...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

... has released clinically annotated gene expression profiles for 60 tumor specimens, completing the initial phase of the nation’s first and eventually largest public database dedicated to standardized gene expression data. The clinically annotated dataset is available in the public domain through the National ...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...statistical analyses to search for gene expression profiles that were associated with patients' therapeutic outcomes. They looked for patterns in analyses of single genes, gene pairs, and gene triplets, and found their model's predictive accuracy increased with gene number. They also looked for genes that sho...

Anammox bacteria produce nitrogen gas in oceans' snackbar

...ments with stable isotope labeled nutrients, depth profiles of unique membrane lipids (ladder molecules), fluorescence microscopy and DNA analyses of water samples was used to proof the abundance of anammox bacteria in the Atlantic Ocean. The discovery of anammox bacteria in the open ocean has major consequen...

Study reveals dramatic difference between breast cancers in US and Africa

...was 44. Studies suggest that the rate and genetic profiles of breast cancers in African American women are likely to fall somewhere in between, with a slightly lower lifetime incidence of breast cancer than Caucasians but earlier onset and worse prognosis. African American women under the age of 35 have a 50...

Affymetrix Launches New Globin-Reduction Kits and Protocol Developed with PreAnalytiX

.... "An accurate picture of in vivo gene expression profiles is essential for understanding gene regulation as ...t trend towards the correlation of gene expression profiles of whole blood and tissue samples. With the new GeneChip Globin-Reduction Protocol and associated re...

Gov't Creates Gene Database of Normal Human Tissues

...r.gov/oncology/oncogenomics/) will find expression profiles for 18,927 genes, which include most of the genes ...enes, different from all others. However, the gene profiles from different organs that share similar biological functions also showed patterns of expression. Fo...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

...amous cell carcinoma, and found that their genomic profiles overlap in every area but one: squamous cell carcinomas contain an area of gene amplification, or over-copying, not found in adenocarcinomas. Among the few genes in that area is one called p63, which is known to play a role in the ability of skin cel...

Arthritis: What Wnt wrong?

...ritis. The article by Nakamura et al., "Expression profiles and functional analyses of Wnt-related genes in human joint disorders," appears in the July issue of The American Journal of Pathology and is accompanied by a commentary. Wnt is best known as a proto-oncogene because its disruption can lead to cance...

The genetic origins of corn on the cob

...o we were delighted to find that they have similar profiles of ramosa1 activity," says Martienssen. ...

$6.5 Million Grant for Microarray Center at Yale School of Medicine

...o we were delighted to find that they have similar profiles of ramosa1 activity," says Martienssen. ...

Researchers seek to discover what really happens when a virus enters the body

...own viruses, or to map unknown viruses to existing profiles to better predict their behavior and start appropriate treatment. Ultimately, their work should contribute to what starts an immune response. And as NIH's Matzinger says, knowing what initiates an immune response will affect and, researchers hope, ...

USC researchers determine mechanism of action of chemotherapy drug

...c agent, the researchers looked at gene expression profiles and other biochemical properties of cells from human lung, prostate and lymphoma cancer cell cultures that had been treated with motexafin gadolinium, or MGd. What they found was that the drug created oxidative stress in the tumor cells, increasing t...

Temperature regulates circadian clock in zebrafish

...nimals were raised in the dark, and the expression profiles during the high temperature phase matched those seen during a light phase when animals experienced light-dark cycles. Zebrafish cell lines also proved valuable tools for studying temperature response, showing a similar pattern of clock gene express...

Scientists characterize proteome of human cornea

...neas we can identify differences in the expression profiles that may suggest avenues for therapeutic interventions. Because the cornea is so accessible, the potential for developing effective drugs for the treatment of corneal diseases is good. Furthermore, the work is likely to improve the clinical classific...

Compound from marine bacteria shows potential as multiple myeloma therapy

...wed that NPI-0052 and bortezomib express different profiles for inhibiting the three major proteasome activities. In mice implanted with human myeloma tumor cells, NPI-0052 was well tolerated, prolonged survival and significantly reduced the rate of cancer recurrences. Because NPI-0052 and bortezomib block t...

Microarray technology for tailoring breast cancer therapy

...in Stockholm, Sweden, analysed the gene expression profiles of 159 breast cancer patients using DNA microarray analysis. From these samples they identified the genetic signatures shown by 38 patients who had a poor prognosis - defined as relapse or death from any cause within 5 years. The remaining 121 patien...

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