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Tag: "profile" at biology news

Faster, low cost sequencing technologies needed to drive era of personalized medicine

...ilor medical treatments to an individual's genetic profile for diagnosing, treating, and ultimately preventing many common diseases such as cancer, heart disease, diabetes and obesity. ASU chemist Peiming Zhang and his collaborator Jian Gu have been awarded a $897,000 grant under this program for an ambi...

Uncovering DNA's 'sweet' secret

...accomplished sculptor. Yet the graceful, sinuous profile of the DNA double helix is the result of random chemical reactions in a simmering, primordial stew. Just how nature arrived at this molecule and its sister molecule, RNA,remains one of the greatest - and potentially unsolvable - scientific mysterie...

Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis

...wn about the prediction power of a gene expression profile as compared to well-known clinical and pathologic predictors," according to Ping Yang, M.D., Ph.D., the corresponding author of the study that appears in the November issue of Cancer Epidemiology, Biomarkers and Prevention (CEBP). The study's first a...

Pair of microRNA molecules controls major oncogene in most common leukemia

...studied, Pekarsky said. "You can look at the miRNA profile and say whether the cancer is aggressive or indolent," he said. And of the two miRNAs, miR-29 offers the most predictive power, Pekarsky added. "We have a lot of work to do to characterize these miRNAs because we don’t even know whether they work ...

Complexity constrains evolution of human brain genes

...r more active, or even more complex, transcription profile than chimpanzee," the authors note. "We suggest that such abundant and complex transcription may increase gene-gene interactions and constrains coding-sequence evolution." Future studies of brain function and evolution will increasingly take advan...

Why mice don't get cancer of the retina

...etinoblastoma, whereas mice with a similar genetic profile do not develop the cancer. Stacy Donovan and Brett Schweers from St Jude Children's Research Hospital in Memphis, USA and colleagues from St Jude's and from the University of Tennessee Health Science Center in Memphis, studied the expression of the...

Study provides first look at the 'birth' of a retina cell

...ified the rods at various stages and generated the profile of genes at each stage. This, for the first time, provided a handle for investigating the precise process of rod differentiation. Rods, along with cones, are photoreceptors, which account for 70 percent to 80 percent of all cells in the adult retin...

Large-scale genomics project will hunt genes behind common childhood diseases

...son. Tailoring treatments to a patient's genetic profile represents an era of personalized medicine still in its early stages. Part of the research task ahead, said Dr. Hakonarson, is not only to map gene variants to disease risk, but also to investigate how genes interact with environmental factors. "We...

'Signature' of chromosome instability predicts cancer outcomes

...alth Sciences and Technology report that a genetic profile indicating chromosomal instability -- an increased tendency to develop chromosomal aberrations, critical in cancer development -- is predictive of clinical outcome in a broad range of cancer types. Using data on gene expression (activity) from 18 ...

First 'encyclopedia' of nuclear receptors reveals organisms' focus on sex, food

... In the anatomical study, researchers used mice to profile the location and activity of the superfamily of nuclear receptors. They found that receptors, by virtue of similar patterns of expression in certain tissues, separate into two main clusters to regulate reproduction and nutrient metabolism. Dr. Mangel...

Mayo Clinic study finds two genes predict outcome for breast cancer patients

...ical Cancer Research. "The HOXB13 and IL17BR gene profile was previously discovered as a potential marker of relapse in hormone-receptor positive breast cancer treated with tamoxifen," says Matthew Goetz, M.D., who co-led the project with James Ingle, M.D. and Fergus Couch, Ph.D. "Our new study shows that ...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...lans to expand the test group and will continue to profile women with atypia who did and who did not develop breast cancer in an attempt to identify early predictors of risk. Reduction in the Risk of Human Breast Cancer by COX-2 Inhibitors: Abstract No. 2352 Results of a five-year study have shown for th...

AIDS-related cognitive impairment exists in two separate forms

...tients with surgery alone, he said. "This protein profile might be used to identify groups of patients who, independent of stage, should be offered adjuvant chemotherapy, and groups of patients who should not be offered chemotherapy," Nielsen said. "Such possible patient differentiation should, of course, b...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...tients with surgery alone, he said. "This protein profile might be used to identify groups of patients who, independent of stage, should be offered adjuvant chemotherapy, and groups of patients who should not be offered chemotherapy," Nielsen said. "Such possible patient differentiation should, of course, b...

US woman gives birth to baby from world's first frozen donor egg bank

... transporting a donor that fits the woman's family profile to the infertile woman's location for treatment. The infertile woman is given the opportunity to choose the timing of her pregnancy, without involving the ongoing life and complications of a third party donor, by selecting and purchasing the eggs w...

Dogs keep dying: Many owners unaware of toxic dog food

...foundly affect blood clotting. A minimum screening profile should assess the liver enzyme ALT to detect damage to the liver, serum cholesterol, total bilirubin concentration and the activity of the anticoagulant proteins antithrombin III (ATIII) and protein C. The coagulation protein tests, which have been a...

Georgia Tech accelerates drug discovery with new IBM supercomputing cluster

... more accurate decisions in research and raise the profile of the Institute among the nation's most elite research facilities." "Only the most technologically savvy universities are able to compete in the field of drug discovery and bioinformatics," said Mike Cassidy, president and CEO of the Georgia Resear...

MiRNA fingerprint identified in platelet formation

... half of that number are also members of the miRNA profile in normal platelet cell development ?suggesting that this small subset may be most important in understanding how AMKL develops," says Garzon.Researchers believe that more knowledge about miRNA could lead to a new class of targeted therapies that may...

Minor mutations in avian flu virus increase chances of human infection

...itoring changes in the receptor binding preference profile where infection is active, according to according to Jeremy M. Berg, the director of the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health (NIH). The glycan microarray was developed by The Consortium fo...

Relic of life in that Martian meteorite? A fresh look

...an unresolved issue. The team had a complete depth profile of the meteorite. Lead author Andrew Steele explained, "By using micro-Raman spectroscopy and a scanning electron microscope we could detect both the structure of the minerals and the forms of carbon present. We did a similar analysis on carbonate gl...

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