New approach to BSE successful in lab
...es like a stroke. Interestingly, mice which cannot produce any PrP-C appear to be completely healthy. This ha...cells of mice in such a way that they were able to produce siRNAs in place of the ‘healthy?PrP-C protein,?explains Professor Alexander Pfeifer, director of the...Vaccine-producing 'plant-factories'
.... Amongst other applications, these can be used to produce oral vaccines which, upon being ingested, will be able to immunise against diseases. Moreover, this discovery opens the door to the design of protein-manufacturing plants of great interest therapeutically and in the development of vaccine antigens. ...Male contraception: One door opens, another closes
...s of mice and found some effect, but not enough to produce infertility. "Biology is full of surprises. Clearly in the case of miglustat, a man is not a mouse," he adds. Next? So with Adjudin showing positive results--but in rats--and miglustat no longer an option, will men see a new contraceptive...Fight weeds with plant pathogens
...gens that are isolated from weeds and are grown to produce large numbers of infective propagules (such as spores). Infective propagules are applied at rates that will cause high levels of infection, which will greatly reduce the growth of, or kill the target weed before economic losses are incurred. Annual a...Discovery in the evolution of the immune system absorbing cells
... this discovery will be used in the near future to produce a new design of vaccines for fish in order to stimulate phagocytosis in antibodies for B cells, increasing the effectiveness of the vaccine". The study of comparative biology remains an important source of scientific knowledge. Several years ago, t...Heart smart: new drug improves blood flow
...n a blockage occurs, the cells lining the arteries produce nitric oxide to signal to the arterial muscles that they need to dilate the artery and allow more blood through. But free radicals destroy a key enzyme that allows the arterial cells to respond in this way, so the signal doesn't get through. Howeve...Older fathers more likely to have autistic children
...n, a change in the sociocultural environment could produce a change in paternal age at birth. In theory, it could thereby lead to a change in the incidence of genetic causes of autism." "Although further work is necessary to confirm this interpretation, we believe that our study provides the first convinc......iring during meiosis, so even those who mate can't produce fertile offspring." The question remains whether new binding sites or new forms of zinc-finger protein lead rapid evolution in the worms. And there are other questions: in C. elegans, and also C. remanei, there are only four kinds of ZIM proteins...'Protecting virus' offers instant flu protection and converts flu infections into their own vaccines
...he body's immune system, so that white blood cells produce antibodies that attach to the surface of the virus and start the process of killing it. This works well for many diseases, such as smallpox, polio and measles, but is much less effective with influenza, as the coat of the flu virus is continually ch...Tiny Tampa Bay fish key to evolution of immune system
...ore of this molecule, then we expect to design and produce more stable monoclonal antibodies for therapy," he said. Neil S. Greenspan, M.D., Ph.D., a professor of pathology at Case Western Reserve University School of Medicine, called the study "captivating and thorough." "However, I expect that further re...Tarantula venom and chili peppers target same pain sensor
... an electrical signal that travels to the brain to produce pain. The researchers examined venoms from 22 spider and scorpion species whose bites are known to cause pain. Venom from the tarantula Psalmopoeus cambridgei activated the capsaicin receptor, also called TRPV1, and the researchers identified thre...Transplanted brain cells hold promise for Parkinson's disease
...ecomes less effective, doses are increased and can produce more dyskinesia, loss of controlled movement. Centers such as MCG are exploring new ways to slow disease progression, diagnose it earlier and more accurately monitor its progression....Diabetes slows nerve recovery after heart transplant
...nic disease that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Such a deficiency results in increased concentrations of glucose (sugar) in the blood, which can damage many of the body's systems. Diabetes mellitus is a known major ris...Scientists discover way to block growth of prostate cancer cells
...auses oxidative stress, a condition in which cells produce an excess of oxygen-free radicals, which are known to play a key role in cell signalling and prostate cancer development. "These results demonstrate that polyamine oxidation is one of the major causes of androgen-induced oxidative stress in prosta...Comments, experts and background on the 2006 Nobel Prize in chemistry
...is critical for life. If it stops, cells no longer produce enzymes and other proteins essential for life and health. With no new protein synthesized, an animal will die within days. Death can also result from the ingestion of certain poisons, which block an enzyme needed for transcription. Cancer and heart d...Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia
...expected turn in solving the mystery of how plants produce lysine, one of the 20 amino acids normally found i...ore, they found that the pathway used by plants to produce lysine is probably used by Chlamydia to synthesize a chemical found in bacterial cell walls. It is ...How mammals fuel milk production may have implications for cancer
...a typical 21-day course of lactation, a mouse will produce its entire body weight in lipid as well as three times its total body weight in milk, which consists of lipid, protein, and lactose. To accomplish this, two distinct developmental programs must be executed: first, cells must proliferate and different...Eating protein boosts hormone that staves off hunger
...ers found that genetically modified mice unable to produce PYY ate more and became markedly obese. The genetically modified mice were also resistant to the beneficial effects of a high-protein diet, the researchers reported, demonstrating a direct connection between protein and PYY. When the researchers tr...Discovery of the first resistance gene to rice yellow mottle virus
..., O. glaberrima, RYMV infection does not generally produce leaf symptoms, or have any impact on the harvest production. However, these varieties do not have the agronomic characteristics sought after for intensive irrigated cultivation or growing on low-lying land, where the disease provokes most damage. IRD...... can create thousands of different hybridomas that produce antibodies effective against different viruses and diseases like cancer. Lu's research regarding the development and use of this technology was published online Monday (Dec. 4) in the journal Applied Physics Letters and is scheduled to appear in p...