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Tag: "probing" at biology news

Herpes virus hijacks DNA repair process

June 13, 2007 -- Scientists probing the details of viral infection have discovered an intriguing surprise: in mice, herpes viruses hijack their host cells' tools for fixing DNA damage and use those tools to enhance their own reproduction. The DNA damage response normally fixes DNA err...

Technique monitors thousands of molecules simultaneously

...nding requirements of the receptor. Traditionally, probing a receptor this way has been done by making a libr...or's, CombiMatrix in Seattle, Moeller saw a way of probing the binding of a library with a receptor without the need for washing by putting each member of the ...

New study sheds light on 'dark states' in DNA

...matter in the universe ?there was no direct way of probing it. The Ohio State chemists used a technique called transient absorption, which is based on the idea that molecules absorb light at specific wavelengths, and allows them to study events happening in less than a picosecond. They found that DNA dissi...

Primitive yeast yields secrets of human cholesterol and drug metabolism

By first probing the way primitive yeast make cholesterol, a team of scientists has discovered a long-sought protein whose human counterpart controls cholesterol production and potentially drug metabolism. The collaborative study by investigators at Johns Hopkins Un...

T-ray breakthrough could make detecting disease far easier

...ch could be useful in applications like endoscopic probing for cancerous cells or explosive detection. "This is a significant development that would allow unprecedented accuracy in studying tiny objects and sensing chemicals using T-rays" said Dr Stefan Maier, of the University of Bath's Department of P...

Gene-bender proteins may sway to DNA

... sub-microseconds. It gave us a new time window on probing protein-DNA interactions," Ansari said. That broader time window, obtained in combination with the stopped-flow measurements, provided the first direct observation of DNA bending when bound to a DNA-bending protein. "We found that the time-scale...

Researchers show how brain decodes complex smells

...nput is smell, sight or sound. Shea suggested that probing the olfactory system could help scientists better understand, for example, how the various biological and neurological components underlying perception formed and evolved. ...

Long-term changes in experience cause neurons to sprout new long-lasting connections

... "What we think they are doing is reaching out and probing for potential neuronal partners. And while most of them retract, with novel sensory experience some populations of these new spines make connections that constitute beneficial new wiring. So those spines gain bulk and are stabilized as persistent spi...

Molecule by molecule, new assay shows real-time gene activity

...side -- greatly increases scientists' precision in probing genetic activity. Using the new assay, described this week in the journal Science, researchers led by Harvard's X. Sunney Xie counted, one by one, protein molecules generated in small bursts within cells as multiple ribosomes bound to single copies ...

Mouse genome much more complex than expected

... from Australia, Asia, Europe and the US have been probing the genome of the mouse in a joint study lasting several years. Their results in some aspects have completely overturned geneticists' traditional assumptions. The findings are available in the prestigious journal Science on 2nd September. The general...

Embryonic stem cells accrue genetic changes

... or no measurable effect at all. In addition to probing changes in the nuclear and mitochondrial DNA sequences and copy numbers, the researchers examined whether the cells' genetic material had shifts in marks that sit on genes and are passed from cell to cell during cell division. These so-called epigene...

Eliminate Data Analysis Bottlenecks in Drug Discovery

... closer, says Puigserver. The researchers are now probing the pyruvate-sirtuin1 connection more closely and looking for more details of the sirtuin1-PGC1 interaction. Also on the to-do list: examining sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mamm...

Computational verification of protein-protein interactions by orthologous co-expression

... closer, says Puigserver. The researchers are now probing the pyruvate-sirtuin1 connection more closely and looking for more details of the sirtuin1-PGC1 interaction. Also on the to-do list: examining sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mamm...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

... closer, says Puigserver. The researchers are now probing the pyruvate-sirtuin1 connection more closely and looking for more details of the sirtuin1-PGC1 interaction. Also on the to-do list: examining sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mamm...

Future diabetes drugs may target new protein interaction

... closer, says Puigserver. The researchers are now probing the pyruvate-sirtuin1 connection more closely and looking for more details of the sirtuin1-PGC1 interaction. Also on the to-do list: examining sirtuin1 and PGC1 in other tissues, particularly muscle and fat, two other energy-producing tissues in mamm...

A human parasite with a streamlined mitochondrion

...described, and thus it provides a model system for probing which mitochondrial functions are truly essential for eukaryotic cells. ...

Gene therapy for Parkinson's disease moves forward in animals

...in Sunnyvale, Calif., who recently chaired a panel probing GDNF experimentation for the Michael J. Fox Foundation for Parkinson's Research. "This is additional experimental evidence that suggests that it can be a promising approach to this disease using in vivo gene therapy, which is very applicable to human...

X-Ray Beams And Fruit Fly 'Flight Simulator' Aid Scientists' View Of Muscle Power

...illuminating the working muscles during flight and probing the molecular motions deep within the muscle cells.?/p> These experiments uncovered previously unsuspected interactions of various proteins as the muscles stretch and contract. The results suggest a model for how these powerful biological motors ...

Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease

...aces and detect energy differences by mechanically probing molecular surfaces. In a poster presentation at the American Chemical Society's annual meeting, the researchers will describe the first biophysical analysis of interactions between monomers that form the amyloid fibrils associated with Parkinson's d...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...in Sunnyvale, Calif., who recently chaired a panel probing GDNF experimentation for the Michael J. Fox Foundation for Parkinson's Research. “This is additional experimental evidence that suggests that it can be a promising approach to this disease using in vivo gene therapy, which is very applicable to human...

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