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Tag: "probes" at biology news

One species, many genomes

...pecially designed DNA probes. "All together, these probes would have seven times the length of human genome," illustrates Weigel the extent of the project. The data were evaluated with several specially designed statistical methods, including a variant of machine learning. The result of this painstaking a...

In nature, proteins sweep up nanoparticles

...Electron Microscopy, a national user facility that probes material at the nanoscale. They found that the zinc sulfide nanoparticles were arranged in dense aggregates. Such tightly packed metal sulfide formations are not new to scientists, but they do beg a question that remains unanswered: Why do the nanopa...

pHLIP, a novel technology to locate and treat tumors

...archers demonstrated that by attaching fluorescent probes to a pHLIP peptide, tumors could be detected. They expect that by attaching and delivering active agents with pHLIP, that tumors may be able to be treated. Targeting is based on the fact that most tumors, even very small ones, are acidic as a result ...

UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice

...eNardo and her colleagues infused trillions of the probes -- more than 10,000 can fit on the end of a straig... human breast tumors. Once in the bloodstream, the probes began to seek out and latch onto receptors on the surface of malignant cells. Three days later, t...

Infection detectives use disease 'fingerprints' to track common infections in children

...cial gene chip called a microarray, which contains probes for the whole human genome and measures which genes are turned on or off. In this study, researchers analyzed gene expression patterns in leukocytes from 29 children at Children’s known to have one of four common infections: flu (influenza A); s...

Triplex assay used to assay duplex genomic DNA

...o they can be mixed with standard amounts of oligo probes for the purpose of automatic in solution assay. The instrument is easy to program, self-cleaning and inexpensive. Daksis indicated that she expected to soon publish data on the use of the Genome Flow® instrument to carry out triplex assaying of ge...

Faster, low cost sequencing technologies needed to drive era of personalized medicine

...ce DNA by applying a sample to single stranded DNA probes attached to a chip. An atomic force microscop...cing by hybridization are limited by the number of probes that can be placed on a chip," said Jian Gu, a research staff member in the Center for Applied NanoB...

Dig deeper to find Martian life

...s that the chance of finding life with the current probes is slim. Scientists will need to dig deeper and target very specific, hard-to-reach areas such as recent craters or areas where water has recently surfaced. Dr Andrew Coates, UCL Department of Space & Climate Physics, said: "This study is try...

Altered perception of reward in human cocaine addiction

...ith sensitive behavioral, cognitive, and emotional probes to optimize the study of drug addiction, a psychopathology that these tools have helped to identify as a disorder of the brain." Goldstein will present details of these studies at a press conference on neuroscience and addiction at the Society for...

Study finds the air rich with bacteria

...ab's Earth Sciences Division. Their DNA microarray probes air samples for a gene involved in making proteins, called 16S rRNA, which is found in all bacteria. The square-shaped microarray, which is called PhyloChip and is roughly the size of a quarter, can detect up to 9,000 different types of this gene, ea...

Study offers innovative profile of enzyme that aids tumor growth

...ivity-based proteomics probe for this enzyme. Such probes are now available for many enzyme classes that participate in cell metabolism, so Cravatt suggests "a large swath of the enzyme proteome" could be addressed using the study's experimental strategy. "The success of our study opens the door to ass...

3-D ultrasound scanner could guide robotic surgeries

...ller ultrasound arrays, the researchers engineered probes that could fit inside catheters threaded through blood vessels to view the vasculature and heart from the inside. Earlier this year, the team reported another advance: a 3-D ultrasound device including 500 tiny cables and sensors packed into a tube...

AIDS-related cognitive impairment exists in two separate forms

...erson University used a microarray chip containing probes for most of the known miRNAs in human and mouse. The investigative team, led by Bruce Boman, M.D., Ph.D., director of Genetic and Preventive Medicine at Jefferson, used the array to first characterize the miRNA expression pattern in intestinal epithe...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...erson University used a microarray chip containing probes for most of the known miRNAs in human and mouse. The investigative team, led by Bruce Boman, M.D., Ph.D., director of Genetic and Preventive Medicine at Jefferson, used the array to first characterize the miRNA expression pattern in intestinal epithe...

Berkeley researchers lay groundwork for cell version of DNA chip

...rous-containing phosphine, as a means of attaching probes and reagents to cell surfaces, or to link different molecules inside of the cells. "The Staudinger ligation has been shown to be both cell friendly and precise, so we exploited the reaction to very specifically link a DNA molecule to the surface o...

Study suggests that publicly available genome data may contain small but significant errors

...sion yeast S. pombe and examined how they bind to probes arrayed on a glass slide, they were able to computationally derive the "distance" between probes in the genome and organize the probes along the genome. The resulting physical map of the S. pombe g...

Powerful new tool for studying brain development

... expression is visible because special tags called probes bind to messenger RNA (mRNA)--the decoded form of the gene--and release a signal that can be seen using a special microscope. Gene expression refers to the production of mRNA, which becomes the blueprint the cell uses to make the protein coded for by...

Rare Tibetan antelope listed as endangered

Three-dimensional ultrasound probes built by researchers at Duke's Pratt School of Eng...engineers said their demonstration showed that the probes could give surgeons a better view during human endoscopic surgeries in which operations are performe...

3D ultrasound device poised to advance minimally invasive surgery

Three-dimensional ultrasound probes built by researchers at Duke's Pratt School of Eng...engineers said their demonstration showed that the probes could give surgeons a better view during human endoscopic surgeries in which operations are performe...

New nanosensor uses quantum dots to detect DNA

Using tiny semiconductor crystals, biological probes and a laser, Johns Hopkins University engineers ha...r that, the Johns Hopkins team used two biological probes made of synthetic DNA. Each of these probes is a complement to the DNA sequence the researchers are ...

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