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Tag: "prion" at biology news

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

...sease. Since then, barriers to the transmission of prion diseases between species "have emerged as a major ...ses are caused by misfolded variants of the normal prion protein, which aggregate into fibrous tangles called amyloid fibrils and cause fatal wasting of brai...

Strongest proof yet found for prion hypothesis

...in test tubes, because what is needed to prove the prion hypothesis completely is to be able to produce thi...author of the paper. "The evidence in favor of the prion hypothesis was strong, but the final proof was still missing. Now we have supplied this proof." Sot...

First technology to remove prions that cause vCJD from blood launched

...nown as Mad Cow Disease. The CE mark means the new prion reduction filter meets pan-European essential requ...fety of medical devices. "The availability of our prion reduction filter is a seminal event heralding a new era in blood safety," says Eric Krasnoff, Chairm...

Research into how prions act in the brain could hold the key to defeating diseases

...ry. 'There is much we do not know about prions and prion diseases but our research teams are following seve...ly no simple and accurate way to diagnose types of prion disease such as vCJD, no effective way of managing or treating patients and no cure is yet in sight....

Active Vaccine Prevents Mice From Developing Prion Disease

...n both the United States and Europe are working on prion vaccines. But the NYU study is important because i... percentage of animals from developing symptoms of prion disease, explains Thomas Wisniewski, M.D., Professor of Neurology, Pathology, and Psychiatry, and th...

Unweaving amyloid fibers to solve prion puzzles

...on of low resolution tools to analyze varieties of prion strains and piece together the puzzle of how amylo...T. Prions are in the business of converting other prion molecules to join their ranks. And as they join together, they can create an amyloid fiber. To under...

Variant prion protein causes infection but no symptoms

Abnormal prion proteins are little understood disease agents invo... research suggests that a variant form of abnormal prion protein--one lacking an "anchor" into the cell membrane--may be unable to signal cells to start the ...

New results validating Pall prion reduction filter disclosed at ISBT Congress

...er System, which was CE marked with a 99.9 percent prion removal efficiency in May 2005. It is the first te...radic CJD. Sporadic CJD is the most common form of prion disease that affects humans. The new research showed a 99.9 percent reduction of the prion. "This s...

Prions rapidly 'remodel' good protein into bad, Brown study shows

...otein when it comes in contact with the infectious prion form in yeast: The protein converts to the prion form, rendering it infectious. In an instant, good protein goes bad. This quick-change "mating" man...

New evidence questions the simple link between prion proteins and madcow disease

...istant people do not absorb the disease-associated prion protein (PrP) from their guts. To test this, the ...e. When they injected material containing abnormal prion protein (PrP) into the sheep's gut, it was equally absorbed by all sheep. "This clearly shows that ...

Successful cell engineering may lead to mad cow prevention, say researchers

...ce a goat cell line in which the gene encoding for prion protein (PrP) was targeted for silencing by a process known as RNA interference. They then utilized these cells for nuclear transfer to produce a cloned, transgenic goat fetus which exhibited a greater than 90 percent knock down of PrP. Previous stu...

New test to detect rare proteins in blood

...cers (such as breast cancer), Alzheimer's disease, prion diseases, and possibly psychiatric diseases relati...re, but medically important molecules, such as the prion protein (for mad cow disease with Mansun Sy at Case Western University) and TNF-alpha (for autoimmun...

History of human cannibalism eats away at researchers

...as not been a major selective driving force on the prion protein gene, as has recently been proposed. Thei...luate historical patterns of human migration. The prion protein gene ( PRNP ) encodes a protein that can abnormally fold and amass in brain tissues to cause...

Brittle prions are more infectious

... Institute researcher have discovered that brittle prion particles break more readily into new "seeds," whi...ckly. The discovery boosts basic understanding of prion infections, and could provide scientists with new ideas for designing drugs that discourage or preve...

New technology to speed up research into Huntington's disease

...ogical dysfunction such as Alzheimer's disease or prion disease, and particularly where motor deficits make cognitive testing difficult or impractical. Dr Morton said "we are pleased at just how effective the test was and already clinical trial companies are showing an interest in the touch screen system"...

New approach to BSE successful in lab

...ions. What is even more peculiar: exactly the same prion proteins occur in healthy animals. The only differ...t is an irresistible chain reaction. The malformed prion proteins can be deposited in the brain, thereby destroying brain tissue. Prion diseases are always f...

Prion disease treatable if caught early

Studies in mice have indicated that the effects of prion disease could be reversed if caught early enough. ...ping early treatments that aim to reduce levels of prion protein in the brains of people with prion disease. Also, they said that their findings suggest test...

Brown team finds crucial protein role in deadly prion spread

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectio...gmentation we studied has a big impact on how fast prion diseases spread and may also play a role in the accumulation of toxic proteins in neurodegenerative ...

Scripps research study reveals structural dynamics of single prion molecules

...bles protein-based inheritance in yeast. When this prion protein misfolds, it converts into self-perpetuati... Interestingly, the new study revealed that yeast prion protein Sup35 lacks a specific, static structure in its native collapsed state. Instead, the compact...

Scientists identify prion's infectious secret

... framework for us to begin exploring properties of prion biology that, up until now, have proven difficult ...yloids. (The brains of animals that have died from prion infections are literally packed with amyloid clumps.) In order to glean insights into the mechan...

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