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Major link in brain-obesity puzzle found

...’s partnership with JAK2 is an important one. In a previous paper, Rui and his former mentor and current colleague Christin Carter-Su, Ph.D., showed that SH2B1 encourages the action and production of JAK2, unlike two other proteins that have been shown by other teams to reduce its activity. Carter-Su is a pro...

Chromosomal microarray analysis proves accurate

...ty in children with various disabilities where the previous chromosomal testing did not. This study involved two versions of the test, and the newer version was more successful in identifying chromosomal abnormalities. The targeted microarray analysis used here is essentially a gene chip method of assessin...

'The eyes have it' -- Autism research yields surprising results

...te of others by looking at their eyes, contrary to previous research, a new University of Nottingham study has found. In findings that contradict previous studies, psychologists found that autistic children can ‘read?a stranger’s mental state based on tha...

Light wine intake is associated with longer life expectancy in men

...d to those who consumed no alcohol. Most of the previous studies assessed alcohol intake at baseline; however, in this study researchers collected detailed information seven times over 40 years. "Consumption patterns usually change during life," Streppel said. "This enabled us to study the effects of long...

Prion disease treatable if caught early

...ht that the disease is untreatable. However, in previous studies with prion-infected mice, Mallucci and colleagues found that early brain degeneration can be reversed if prions are depleted in neurons. In the new studies published in Neuron, they established that cognitive and behavioral impairments—whi...

Researchers show that veins stiffen as we age

...sy of the American Medical Association " Based on previous research, we suspected that the veins of the older adults would be less flexible than those of the younger adults," Farquhar said. "But we didn't know if that might be due to a functional process, such as a chronic constriction of the muscles around ...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

... are much closer evolutionarily to humans than any previous model organism treated by this molecule, which off...ivity and fatty acid oxidation. It's been shown in previous work that the lifespan of worms has been extended by the addition of copies the AMPK gene, and chron...

Global map shows new patterns of extinction risk

...h published today. Contrary to conservationists' previous assumptions, the map shows conclusively that geographical areas with a high concentration of endangered species from one group, do not necessarily have high numbers from the others. This new finding has far-reaching implications for conservation plan...

Backache beaten by good vibrations?

...s than 12 weeks, are not pregnant and have not had previous spinal surgery. The volunteers will receive advice on managing their pain and either eight sessions of therapeutic ultrasound (TU) or eight sessions of sham TU. They will also be assessed for pain, disability and general health before the trial, i...

End-of-life care can be improved

...re researchers are taking the lessons learned from previous observational studies and using them to develop and test generalizable interventions that improve the quality of ICU end-of-life care. The Critical Care Medicine supplement includes 20 articles evaluating end-of-life issues, including palliative car...

Interaction between lymph and liver cells may affect immune response

...old age," the authors conclude. "We have shown [in previous studies] that old age is associated with dramatic reductions in the fenestrations of LSECs therefore the altered immune responses of older people might in part be mechanistically linked to reduced opportunity for TEHLI in old age." In an accompany...

Why don't all moles progress to melanoma?

...ile other oncogenes didn't," Soengas says. In a previous study, Soengas and colleagues found that certain oncogenes use a different senescence mechanism, which doesn't activate the ER, to block the transformation of melanocytes. Both these mechanisms work in addition to or independent from other well-know...

Underweight women at greater risk of miscarriage

...ed risk factors, such as increased maternal age, a previous history of miscarriage, and infertility, the cause... pregnancy. The findings confirmed the findings of previous studies into possible risk factors, for example in relation to increased maternal age and alcohol co...

Hundreds of thousands of viral species present in the world's oceans

...y with decreasing latitude, a trend that parallels previous findings from terrestrial ecosystems. In fact, the researchers predict that the world's oceans hold a few hundred thousand broadly distributed viral species, with some species-rich regions likely harboring the majority of these species. ...

Researchers seek to design first treatment for neuroAIDS

...te of Mental Health, is a competitive renewal of a previous grant, but with a shift in focus. In the original grant cycle, Gelbard and Sanjay Maggirwar, Ph.D., assistant professor in the Department of Microbiology and Immunology at the Medical Center, identified an enzyme, GSK-3b, that when over-activated by ...

New brain-chemistry differences found in depressed women

...tment with medication." The research builds on previous studies that found differences in the body's and brain's stress-response system among people with depression. But this is the first time that specific differences in the mu-opioid system have been shown between people with depression and those withou...

Comprehensive model is first to map protein folding at atomic level

...uration, and at least a thousand times longer than previous methods -- is described this week in the Proceedings of the National Academy of Sciences. "For years, a sizable army of scientists has been working toward better understanding how proteins fold," says co-author Eugene I. Shakhnovich, professor of ...

Good times ahead for dinosaur hunters, according to U of Penn scientist's dinosaur census

...t walked the earth. Their findings, combined with previous studies suggest that nearly half of all dinosaur genera that existed did not leave behind fossils that could be found. "I would never suggest that this prediction, however statistically sound, is the final word on dinosaur diversity," Dodson said. "...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

...e able to make this process visible by building on previous research, using an NRL gene regulatory element to tag the rods with a green fluorescent protein. This enabled Kellogg scientists to illuminate the rods, which begin as unspecified cells and gradually differentiate into cells dedicated to light recept...

Study uncovers mutation responsible for Noonan Syndrome

...ine at Harvard Medical School (HMS). "Although previous work had identified mutations in the PTPN11 gene as the cause of Noonan syndrome in nearly 50 percent of cases [and mutations in an oncogene known as KRAS in a small subset of severe cases] the identity of the gene or genes responsible for fully half...

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