New understanding of DNA repair may pave way to cancer treatments
... role in DNA repair, an intracellular process that prevents formation of genetic mutations, including those that lead to cancer. "This is the first time we've seen a protein which has been implicated in gene regulation possess an independent function--in DNA repair--while both functions are uncoupled from on....... In anticancer therapy, an angiogenesis inhibitor prevents the growth of blood vessels from surrounding tissue to a solid tumor. “Recent clinical trials have shown that anti-angiogenic drugs have a favorable impact on colon and lung cancers,?said NCI Director Andrew C. von Eschenbach, M.D. “This study demon...Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
...t, the initial insulating property of the molecule prevents the first electron from ever jumping on to the molecule, a kind of “Catch-22.?Ions in the solution “jiggle?the molecule enough to bring about an unusual configuration of the molecule that does allow the electrons from the electrodes to jump on to the...Cousin of Asian super termite invades Florida
...mical called noviflumuron, a growth regulator that prevents termites from molting, thereby reducing the ability of the worker population to sustain underground colonies. The chemical has a low toxicity to humans and the environment. Less than one gram kills an entire colony containing millions of termites. T...15-year hunt finds cause of pseudothalidomide syndrome
...s. Although there's some evidence that thalidomide prevents blood vessel growth, it's not clear why. If the underlying biology is related somehow, then thalidomide might affect chromosomes and cell division like ESCO2 in Roberts syndrome, Jabs speculates. During normal cell division, every chromosome is copi...Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
...g through the membrane, says Connell. The mutation prevents the cork from sticking. "This is a very conservative mutation in the protein. It was thought that the sodium channel was flexible at this location. We've shown that it is not, that it is rigid," says Connell. That could have implications for medical...Innovative coating could give medical implants a longer life
...rthwestern, which sticks securely to a surface and prevents cell and protein buildup, works for a long period of time. In laboratory studies, the new coating provided effective fouling resistance for more than five months, which Phillip B. Messersmith, associate professor of biomedical engineering in the McCo...Newly discovered protein an important tool for sleeping sickness research
...ay one day enable scientists to create a drug that prevents the manufacture of base J, affecting the trypanosome's ability to vary its antigenic coating, and therefore allowing the human immune system to kill it. Understanding trypanosomes at the molecular level is key to fighting African sleeping sickness a...Breakthrough System for Understanding Ocean Plant Life Announced
...ay one day enable scientists to create a drug that prevents the manufacture of base J, affecting the trypanosome's ability to vary its antigenic coating, and therefore allowing the human immune system to kill it. Understanding trypanosomes at the molecular level is key to fighting African sleeping sickness a...Grass makes environmentally friendly biofuel
...ther biomass crops, the lack of government support prevents the industry from going forward, he says. Cherney has made a comparison of wood pellets with various mixes of grasses and the BTUs (British Thermal Units) produced per pound. He has found that grass pellets can be burned without emissions problems, ...Natural tumor suppressor in body discovered by UCSD medical researchers
... cell growth leading to cancer and cell death that prevents tumor formation. "A drug that turns on PHLPP, so ...ientists discovered a molecule called PTEN*, which prevents activation of Akt, no one to date had determined how to directly turn off Akt once it has been activ...Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
... which dampens down the immune response. LcrV also prevents secretion of tumor necrosis factor (TNF), which causes inflammation. "LcrV is secreted in massive amounts via the type-III pathway during an infection," Schneewind said. "Without it, the bacteria are relatively harmless." Consequently, researchers ...Scientists discover that three molecules may be developed into new Alzheimer's drugs
...his case CDK5. To get a molecule that specifically prevents the enzyme from binding at the pocket is difficult. Of the three compounds that the research group found, the scientists were able to locate where they bind. They found that one binds in the pocket, another binds at the edge of the pocket, and a thi...Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
...his case CDK5. To get a molecule that specifically prevents the enzyme from binding at the pocket is difficult. Of the three compounds that the research group found, the scientists were able to locate where they bind. They found that one binds in the pocket, another binds at the edge of the pocket, and a thi...New type of rejection blocker protects kidneys after transplant
...kidney. By blocking this second signal, belatacept prevents destruction of the kidney without suppressing the immune system's response to viruses and other pathogens. Belatacept is based on research into the molecular basis of immune tolerance. Its precursor, CTLA4Ig, was first shown to induce transplant tol...Woods Hole Research Center plans controlled burn in Amazon rainforest
...sistant to burning because their dense leaf canopy prevents all but a tiny portion of incoming solar radiation from reaching the forest interior, keeping the litter layer too moist to sustain a fire. Now large areas of forest are selectively logged prior to being settled, leaving holes in the canopy; longer, ...Tetanus toxin found to have therapeutic properties
...s. This means it has a neuroprotective effect that prevents the death of the neurons when they are faced with aggressive situations. This is why the scientists believe the harmless toxin fragment could be more effective than neurotrophins as protection against neurodegenerative disorders such as Parkinson's d...Microreactor efficiently regenerates cofactors for biocatalysis
...rge batch reactors, a spontaneous reverse reaction prevents the regeneration of essential cofactors," Kenis sa.... "The absence of a bulk phase in our microreactor prevents the unwanted reverse reaction from occurring, while permitting continuous operation." Using their m......en caused the liver cells to make the protein that prevents bleeding. The researchers also modified the vehicle so that it would express these therapeutic genes only in liver cells, thus reducing the likelihood of negative side effects. The laboratory findings have significant potential for developing imp...