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Tag: "prevents" at biology news

Neuronal 'traffic jam' marks early Alzheimer's disease

...affic jam" within neurons that causes swelling and prevents proper transport of proteins and structures in the cells, according to new studies by Howard Hughes Medical Institute researchers. In mouse models of Alzheimer's disease and in human brain samples from people with the disease, researchers observed a...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

...cts them to become melanocytes, but simultaneously prevents them from differentiating completely. "It gets the show going, but at the same time, prevents the final act," says Epstein. "I call this dual function a "biological capacitor," because Pax3 tell...

Timing is everything: First step in protein building revealed

...ted that eIF1's mere presence on theyeast ribosome prevents the machinery from getting started. Only afterits release from the complex can the ribosome start making proteins."No one had any idea when eIF1 was released from the ribosome, or thatits release might serve an important purpose, so this was a comple...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...r cells produce an enzyme,called telomerase, which prevents telomeres from getting too short socells can keep dividing. Telomerase is not used by healthy cells, andhas been identified as a logical target for anticancer therapeutics.However, recent studies indicate that for this therapy to be effective,telomer...

GATA: a graphic alignment tool for comparative sequence analysis

...r cells produce an enzyme,called telomerase, which prevents telomeres from getting too short socells can keep dividing. Telomerase is not used by healthy cells, andhas been identified as a logical target for anticancer therapeutics.However, recent studies indicate that for this therapy to be effective,telomer...

Critical role in programmed cell death identified

...ls survive; in other words, blocking fragmentation prevents cell death, inducing fragmentation provokes cell death. "This programmed cell death is so important and the more players we know that are involved, the more potential targets we have for therapeutics," Conradt said. During development, for example, ...

UCLA scientists transform HIV into cancer-seeking missile

...unt therapeutic drugs out of the cancer cell. This prevents the drug from taking effect and allows the tumor to continue growing unchecked." In order to track the carrier's journey, the scientists added luciferase ?the protein that makes fireflies glow ?to the AIDS virus. They injected the camouflaged HIV in...

UCSD discovery may help extend life of natural pesticide

... of the glycolipid receptor in each of the mutants prevents Bt from binding. Other members of the research team, coauthors Stuart Haslam and Anne Dell, biologists at Imperial College London; Barbara Mulloy, a biochemist at the Laboratory for Molecular Structure, National Institute for Biological Standards an...

Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows

...egulated, being turned on or off in a fashion that prevents them from simultaneously dragging the peroxisome." In the future, Selvin wants to combine FIONA and an optical trap technique to monitor the speed and direction of a peroxisome, and the force acting upon it. "By measuring force we can determine how...

Polymers with copper show promise for implanted sensors

... important role: it inhibits platelet function and prevents platelets from sticking to the surface of the blood vessels." Over the years, Meyerhoff and collaborators have developed nitric oxide-releasing polymers, then coated sensors with the polymers and implanted the sensors into the arteries of laboratory...

New component of the 'brakes' on nerve regeneration found

... injury is the "braking" machinery in neurons that prevents regeneration. While peripheral nerves have no such machinery and can readily regenerate, central nervous system (CNS) neurons have their brakes firmly in place and locked. Now, two groups of scientists have independently found a new component of tha...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

... and then determine the minimum concentration that prevents bacterial growth. That number was taken and compared with concentrations of the drug in the blood, and from those two numbers a dosing decision is made. “We feel that’s not the optimal way go,?he said. “It doesn’t give you the full story ?it doesn’t...

Researchers identify protein crucial for survival of Lyme-disease bacterium

...tivates them," Dr. Norgard said. "But certainly it prevents them from replicating in the manner that they should to sustain the numbers needed to move from the midgut to the salivary glands. We don't understand the mechanism for that yet, and that will be the next step in our research." Further study of the ...

Alzheimer's cognitive decline slowed

...h factor (NGF), a naturally occurring protein that prevents cell death and stimulates cell function. In surgeries that took place in 2001 and 2002 at UCSD's John M. and Sally B. Thornton Hospital, the genetically modified tissue was implanted deep within the brains of the eight patients who had volunteered fo...

First frozen egg baby born in Canada

... at a rate of more than 20,000ºC per minute, which prevents ice crystal formation and increases egg survival to approximately 90%. The frozen eggs can then be safely stored in the Cryoleaf until it is ready for use, at which point it is carefully thawed, then fertilized. To date, 15 patients at the McGill Re...

Solutions that reduce death of marine life reeled in by International Smart Gear Competition

...t allows more time for productive fishing and also prevents shrimp from being crushed under the weight of fish and bycatch hauled up on deck, making the shrimp more valuable at market. "Reducing wasteful practices like bycatch is essential to the health of our oceans and a win-win proposition for fishermen, ...

Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis

...ply of blood cells," he said. "However, Mcl-1 also prevents the abnormal white blood cells found in leukemia from undergoing apoptosis in response to chemotherapy or radiation. This makes the leukemia cells resistant to treatments designed to damage the cell so it undergoes apoptosis." Opferman is continuing ...

Yeast Network Prevents Damage By Oxygen Radicals

... repair and cell cycle control genes in yeast that prevents the deleterious effects of ROS. "DNA repair and cell cycle control mechanisms are important guardians against cancerous changes in human cells," says Dr. Richard Kolodner, LICR Member and senior author of the study. "However, the effects of ROS on t...

Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment

... the egg is thawed, ice crystals cause damage that prevents the egg from being fertilized. U-M researchers looked beyond traditional techniques to a method of freezing cells called vitrification. This cryopreservation technique allows the eggs to be cooled fast enough that the transformation from liquid to s...

Biologists discover why 10% of Europeans are safe from HIV

...ry a genetic mutation (known as CCR5-delta32) that prevents the virus from entering the cells of the immune system but have been unable to account for the high levels of the gene in Scandinavia and relatively low levels in areas bordering the Mediterranean. They have also been puzzled by the fact that HIV em...

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