New pathways for autoimmune treatment identified
.... This finding opens new pathways for treating or preventing APS1, or autoimmune polyglandular syndrome type 1, and potentially other autoimmune diseases as well, researchers report in the June issue of Nature Medicine. "The body should maintain a balance between killing and suppression," says Dr. Qing-Sheng...Study pinpoints protein's role in cancer spread
... functions to control the activity of a key cancer preventing protein called p53. In some of the body's cells, the biochemical ratio between MDM2 and p53 can become unbalanced causing MDM2 to act as a cancer-promoting agent. The project's lead investigator, Dr Kathryn Ball, a researcher at the University, ex...Tamoxifen for breast cancer prevention does not benefit most women
... the benefits and risks of tamoxifen as a means of preventing the disease. Tamoxifen is a selective estrogen receptor-modulating drug used to treat estrogen receptor-positive breast cancers. In addition, it has been shown to reduce the incidence of invasive breast cancer among high-risk women by up to 49 perc...Matrilin-3 gene discovered to prevent onset of osteoarthritis
...ies in people has been shown to be responsible for preventing the onset of osteoarthritis in adult mice, according to a recent study led by Rhode Island Hospital. The matrilin-3 gene plays a role in early bone development, controls bone mineral density in adulthood and prevents osteoarthritis later in life. ...Selenium-protein deficiency raises prostate cancer risk
...ining proteins in the body that is instrumental in preventing cancer, and that dietary selenium plays a role in stimulating the body's level of these selenoproteins. Two genetically manipulated mice were mated. One was prone to developing prostate cancer. The other had lower levels of selenoproteins. Approxima...Johns hopkins researchers find link between cell's energy use and genome health
... also helps you remember telephone numbers or that preventing such digestion makes you forget them," Boeke added. The research, to be published in the July 21 issue of Molecular Cell, could lead to new strategies one day to slow aging and treat cancer, events closely linked to changes in gene control and ener...Cigarette smoke blocks cell repair mechanism, University of Florida study shows
...hat plays a crucial role in repairing damaged DNA, preventing it from doing its job. The cell, despite its mutated form, can then multiply wildly. A cell with damaged DNA has one of two fates, said Narayan, also a member of the UF Shands Cancer Center. "Its DNA repair machinery can be enhanced and it can f...Montreal researchers identify defects of immune cells
...ing a treatment for the infection and, eventually, preventing it. They are described in an article of the July 1...ibility to candidiasis in these transgenic mice by preventing T lymphocyte mediated acquired immunity to Candida albicans. The results also showed extensive pertu...The molecular mechanism of a diabetes vaccine revealed
... and therefore, help to boost the immune system in preventing the destruction of insulin-producing pancreatic cells," says Cohen. Postdoctoral fellow Dr. Alexandra Zanin-Zhorov spearheaded the project; the other scientists participating in this study were: the late Prof. Ofer Lider, Dr. LioraCahalon, postdocto...Magnetism and mimicry of nature hold hope for better medicine, environmental safety
...ids. "By manipulating droplets so carefully and preventing contamination of the samples, we can detect things like signs of disease or environmentally hazardous materials much better," said research associate Lindsay. "We can analyze things using small droplets that normally would require much larger amounts...Friendly bacteria in chewing gum that bites back
...in the gum will make the S. Mutans clump together, preventing them from becoming attached to the tooth surface. Tests reveal that the chewing gum can reduce the amount of bacteria in the mouth fifty times. Stefan Marcinowski, executive director of research at BASF said that a Lactobacillus product is due to h...Spinal cord bridge bypasses injury to restore mobility
...oglycans by clipping their sugar branches, thereby preventing the scar wall from building. In a National Institutes of Health-supported animal study, 12 rats had spinal injuries at the cervical level 3 (C3) that resulted in impaired motor functions to their right side limbs. The animals had trouble moving, cl...Over-use of antibiotics in fish-for-food industry encourages bacterial resistance and disease
...ibiotics in the rearing of finfish is essential in preventing these detrimental effects to fish, animal and human health. ...Scientists discover why cornea is transparent and free of blood vessels, allowing vision
...cientific mystery, but also hold great promise for preventing and curing blinding eye disease and illnesses such...hat the presence of VEGFR-3 is the major factor in preventing blood vessel formation in the cornea," says Dana, who says that the discovery will have a far reachi...Schepens scientists are first to discover angiogenesis switch inside blood vessel cells
...ular endothelial growth factor. While effective in preventing vessel growth, these drugs have little impact on e... acts on the lipid, it cuts the lipid in two, thus preventing PI3K from using that very same lipid to promote vessel growth. Instead, they learned, the resulting...Study details hepatitis C ability to block immune system response
...by using its protease activity to destroy MAVS. By preventing infected cells from producing interferon, the virus inhibits the body's immune response against HCV, enabling it to persist. "Our new work shows that HCV does not induce interferon-? or antiviral interferon stimulated genes in the infected cells,"...Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
...act with DNA could provide important insights into preventing and treating an array of human cancers. To date, however, despite having learned a good deal about the protein's biochemistry over the years, scientists have been unable to "see" the protein ?using the tools of structural biology ?bound to DNA in its...Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein
... body repairs wounds and may have implications for preventing or treating chronic wounds such as pressure or bed...eed from growth to death faster than normal cells, preventing sufficient hair growth. When cells of normal hair follicles die, they follow a specific and genet...Today's babies are fatter babies
...moking and excessive weight gain during pregnancy, preventing gestational diabetes, and promoting breastfeeding, all of which researchers have shown to be associated with reductions in childhood overweight." ...EGF receptor activation prevents microbes from going more than skin deep
... not only help fight infection, but play a role in preventing infection from developing in the first place. In a study appearing online on June 15 in advance of print publication in the July issue of the Journal of Clinical Investigation, Ole Sorensen and colleagues from Lund University, Sweden, investigated wh...