Cancer related gene p53 not regulated as indicated by previous tissue culture research
...e world indicated that tinkering with the tail end prevented the protein from being flagged for degradation or activation. Instead of accumulating in mouse cells and halting cell division in the genetically engineered mice, the altered p53 protein performed flawlessly: it was unstable when no DNA damage was pr...$5.1 billion would save 6 million children
... almost 11 million child deaths worldwide could be prevented with existing knowledge and treatments. In order t...at least 6 million child deaths worldwide could be prevented with existing interventions to prevent and treat pneumonia, diarrhea, malaria, neonatal sepsis, pret...Disabling gene defuses rheumatoid arthritis in mice
...t. Louis showed that knocking the gene out in mice prevented the development of an arthritis-like disorder by making the neutrophils victims of their own damaging secretions. The newly identified role for the gene, Foxo3a, may open a new window for treating arthritic conditions caused by immune dysfunction. C...Researchers test new therapy for advanced melanoma
... that recognized the melanoma cells as foreign and prevented tumor regrowth. "We were very encouraged by the results of the preclinical studies." Dr. Heller said. "We're hoping this translates into a beneficial treatment for patients." The Phase 1 clinical trial by Moffitt and Genetronics Biomedical Corp is ...Two chemicals boost immune cells' ability to fight HIV without gene therapy
...ne into the immune cells of an HIV-infected person prevented the cells from aging prematurely. The telomerase enabled the immune cells to divide indefinitely, stimulated their production of a viral-fighting molecule and prolonged their power to kill HIV-infected cells. In this study, the scientists isolated i...Computational Method Speeds Mapping of Cell Signaling Networks
..., the large amounts of data the technique requires prevented its application to protein networks. Being able to monitor multiple components in thousands of cells at once was pivotal to the group’s success. Despite technical hurdles, the team believes similar approaches may be used in the future to study system...Probing the promise and perils of nanoparticles
...illing cells in the process. But the damage can be prevented by engineering dendrimers in particular ways, such as modifying their surfaces to make them neutral instead of charged, the scientists found. And, added Banaszak Holl, "not only does engineering make them less harmful, but it also makes them better a...Gene therapy for Parkinson's disease moves forward in animals
...scientists studying small monkeys called marmosets prevented brain damage by producing therapeutic levels of a protein that helps nourish brain cells, said Ron Mandel, Ph.D., a scientist with the University of Florida's McKnight Brain Institute and Genetics Institute who was part of the research team. The pro...Study Models Impact Of Anthrax Vaccine
...model to predict how manycases of anthrax could be prevented under varying conditions. The studyfound that about 70 percent of anthrax cases could be prevented ifantibiotics were distributed within 6 days after exposure and patientswere to take them for 60 day...Gene Therapy For Parkinson's Disease Moves Forward In Animals
...scientists studying small monkeys called marmosets prevented brain damage by producing therapeutic levels of a protein that helps nourish brain cells, said Ron Mandel, Ph.D., a scientist with the University of Florida's McKnight Brain Institute and Genetics Institute who was part of the research team. The pro...Ants Genetic Engineering Leads To Species Interdependency
...the hybrid workforce strategy.When the researchers prevented queens from mating with males of theother species, very few succeeded in making any workers at all, ahandicap that would lead to certain population failure in the field.The new findings suggest that specialization involving reliance oninterspecific h...Probing The Promise And Perils Of Nanoparticles
...illing cells in the process. But the damage can be prevented by engineering dendrimers in particular ways, such as modifying their surfaces to make them neutral instead of charged, the scientists found. And, added Banaszak Holl, "not only does engineering make them less harmful, but it also makes them better a......compounds, called synthetic migrastatin analogues, prevented 91 to 99 percent of metastatic breast cancer cells in mice, and are the first to target only metastatic cells. "They're unbelievably effective, and in vitro study suggests they'll work just as well at inhibiting the migration of prostate and colon c...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...oduced genes to muscle, the immune response can be prevented or attenuated." The muscle-targeted gene therapy might therefore apply to other forms of muscular dystrophy, they added. Muscular dystrophies include many genetic diseases, all of which are characterized by progressive weakness and degeneration of t...Novel Therapy Tested in Mice Could Chase Away Cat Allergies
...ecule designed to block cat allergies successfully prevented allergic reactions in laboratory mice, as well as ...on. “Those results suggested that GFD successfully prevented the immune cells from reacting to cat allergen. The next step was to test GFD in mice that we had ma...The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
...er eliminating the blurry and unwanted light which prevented scientists from looking deep into tissues in the past. The entire procedure is very fast and in a computer supported post-processing step, one or more stacks of images are assembled into a high-resolution film. Another advantage of SPIM is that the ...Inexpensive, mass-produced genes core of synthetic biology advances at UH
...curring genes. The costs ofcurrent technology have prevented us from doing this, but Dr. Gao’sresearch will break down that barrier.?This technology offers tremendous potential benefits, as syntheticgenes could allow for development and production of safer, less toxicproteins that are currently used in disease...