Study illuminates how the plague bacteria causes disease
...difying cell shape, Stebbins said. Mutations that prevented the bacterial proteins' interaction with the host protein significantly impaired YpkA's ability to disrupt the cytoskeleton. Moreover, a mutant strain of Y. pseudotuberculosis that lacked the GDI activity caused significantly fewer problems for infec...'Trojan Horse' agent halts bone metastasis in mice
A novel vascular targeting agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread. Resear...New HIV statistics indicate increasing toll of AIDS on African American community
...accurate information about how HIV is transmitted, prevented and treated. Approximately 250,000 Americans ?many of them African American ?are unaware that they have HIV. These individuals are not receiving life-saving medical care and may unknowingly transmit HIV to sex- and needle-sharing partners. In addit...Flu shot effective against drifted influenza, nasal spray vaccine less so
...The live attenuated-virus nasal spray vaccine also prevented illnesses but was less effective. Both outcomes were determined by laboratory confirmation of flu infection, a University of Michigan study found. Earlier studies had suggested that the nasal spray, sold by MedImmune as FluMist, might offer better...Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy
...r breast cancer, restored skeletal muscle mass and prevented the impaired function characteristic of muscular dystrophies. Importantly, these restored muscles showed an increased resistance to contraction-coupled degeneration--the primary mechanism by which muscle function declines in Duchenne muscular dystrop...First-time analysis reveals millions of Europeans left at risk from influenza
...ere is needless suffering and deaths that could be prevented by increasing the rate of vaccination to include all people at risk of influenza. Our hope is that this model will demonstrate the public health implications of influenza and focus both governments and vaccine suppliers to address the underutilizatio...Cell wall of pneumonia bacteria can cause brain and heart damage
...olecule called PLC inhibitor U73122. The treatment prevented the cell from taking up the fragments but did not appear to interfere with the cell's normal functions. This suggests that a drug that blocks the pathway responsible for pulling cell fragments into the cell might not have serious side effects on the ...Three-in-one virus killer prevents common, often fatal infections
...elopment of adenovirus. "Not only were patients prevented from getting these infections after transplant, but those patients who had infections responded to the T-cell therapy and did not require any other treatment," said senior author Dr. Catherine Bollard, assistant professor of pediatrics, immunology, a...St. Jude test of bird flu vaccine proves successful
... vaccine control did not survive. The vaccine also prevented weight loss in all animals challenged with the virulent virus, suggesting that the vaccine might also protect humans against serious flu-related sickness. The studies included 16 mice or six ferrets in each vaccine or control group. The DNA vaccines...Tamed 11,400 years ago, figs were likely first domesticated crop
...e fruit develops without insect pollination and is prevented from falling off the tree, allowing it to become soft, sweet, and edible. However, because such figs do not produce seeds, they are a reproductive dead end unless humans interfere by planting shoots from the parthenocarpic trees. "Once the parthenoc...Orange, grapefruit juice for breakfast builds bones in rats
...e and grapefruit juice regularly given to lab rats prevented osteoporosis, long considered an unavoidable aging disease in which bones become more likely to break, according to a study by Texas A&M University's Vegetable and Fruit Improvement Center researchers. The article was published in Elsevier's Nutr...Vaccine shown effective against chancroid
...wed that the immunized pigs formed antibodies that prevented the chancroid bacteria from binding hemoglobin and, hence, obtaining the heme it needs to survive, the authors said. In skin biopsies of the immunized animals, the researchers found no viable chancroid bacteria. An HIV vaccine has been elusive in ...Robots manipulating animal behaviour
...leading IT and biology journals. "Time constraints prevented us from exploring all the new and interesting research paths that opened during the project," says the project coordinator. "But we succeeded in our main goal ?showing that an artificial agent such as a robot can modify the collective behaviour of na...Selectively blocking inflammatory signals may protect mice from MS
...his tremendously encouraging," said Popko. "SOCS1 prevented or reduced the harmful effects of interferon gamma on myelin-producing cells. This study solidifies our suspicions about interferon's specific role in demyelinating disease and suggests ways to block it." Although there is currently no reliable way...Gene therapy injected into the brains' of mice with Huntington's disease
...using this delivery method, symptom onset might be prevented in HD mice with this treatment. Results of the study were published in the Proceedings of the National Academy of Sciences of the United States, June 13, 2006. "This could be an important step toward a disease modifying therapy," says co-author Je...Natural vitamin E tocotrienol reaches blood at protective levels
...0 to 25 times stronger than the concentration that prevented the cell death signal. ...Failure of 'scout cells' may lead to cancer in transplant patients
...combined, the TGFb-exposed cells were stronger and prevented the unexposed scout cells from re-stimulating the ...er IFNg levels. They also found that blocking TGFb prevented the EBV-related cancer. We hypothesize that the balance between IFNgÆ’nand TGFb is probably import...Injection may prevent infertility in men receiving cancer chemotherapy
... An injection of AS101 a day before that of Taxol prevented the Taxol-induced weight loss. "Tissue analysis of the testes of Taxol-injected mice showed severe atrophy and empty seminiferous tubules, where the sperm-producing cells are contained", said Mr. Carmely. "In contrast, we saw only minimal testicu...Use of stone hammers sheds light on geographic patterns of chimpanzee tool use
...t to be restricted by geographical boundaries that prevented cultural spread of the technique from animal to animal. The findings, which involve the most endangered and least-understood subspecies of chimpanzee, are reported by Dr. Bethan Morgan and Ekwoge Abwe of the Zoological Society of San Diego's Conserva...... buckle during physical therapy. "The SAM walker prevented my knees from buckling and helped me regain my mobility. I was able to graduate to the therapy on the parallel bars a lot quicker as a result," said Geddis. "NASA's technology in the walker's harness gave me the stability to do squats and knee raise...