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Tag: "presence" at biology news

Viral DNA sequence a possible trigger for breast cancer

...g wrinkle to this study is the previously reported presence of sequences highly homologous to MMTV Env protein in the DNA of as many as 40% of human breast tumors, although a human homologue of MMTV has yet to be found. ...

Association of herpesvirus with lung disorder questioned

... New England Journal of Medicine that reported the presence of the virus in similar samples of lung tissue from a similar number of patients. Both primary pulmonary hypertension and infection with HHV-8 are uncommon, Katano and co-authors explained. Human herpesvirus 8 infection is associated with Kaposi's...

A new mechanism of regulating RNA degradation

... did in human cells," said Maquat, even though its presence in mammalian cells has been recognized for several years. "We were surprised to find that Staufen1 interacts with Upf1," she added. "This is a whole new function for Staufen1 that couldn't have been predicted from the studies in flies, even though a...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

... did in human cells," said Maquat, even though its presence in mammalian cells has been recognized for several years. "We were surprised to find that Staufen1 interacts with Upf1," she added. "This is a whole new function for Staufen1 that couldn't have been predicted from the studies in flies, even though a...

Spleen may be source of versatile stem cells

...ding, the MGH researchers investigated thepossible presence of a protein called Hox11 in these cells. In mammals,Hox11 is a controller of key steps in embryonic development - includingthe formation of the spleen - but it was not known to be present inadults under normal circumstances. In some other animals, h...

Novel technology detects human DNA mutations

... creates a strong signal accurately indicating the presence of a specific target SNP. Proof of principle, reproducibility, and the robust, simple and rapid characteristics of this technology were demonstrated withunamplified DNA samples representing all possible forms of three genesimplicated in hypercoagulat...

Termites feed through good vibrations

...ristic frequency plus other signals indicating the presence of other termites in that "large block", so they chose to feed on the large block without termites. Thus the termites showed that they have the "cocktail party effect". This social information had another important effect: limiting reproduction pote...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...rchers used recently developed probes todetect the presence of Neu5Gc on the cell surface of human embryonicst...re conditions. Thescientists further confirmed the presence of Neu5Gc with a processcalled electrospray mass spectrometry. The percentage of total sialicacids p...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...of the mechanisms by which the parasite senses the presence of its human host and translates environmental cue...ite. Another unusual feature of the genome is the presence of an unprecedented number of tRNA (transfer RNA) genes, which constitute nearly 10 percent of the s...

Timing is everything: First step in protein building revealed

...he research team has demonstrated that eIF1's mere presence on theyeast ribosome prevents the machinery from getting started. Only afterits release from the complex can the ribosome start making proteins."No one had any idea when eIF1 was released from the ribosome, or thatits release might serve an important...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...sis, and thatNedd4 actually destabilizes Dx in the presence of Notch. Thiscompetition between two ubiquitin ligases to permit or suppressactivation of a signaling pathway represents a neat solution to theproblem confronting cells of how to prevent molecular loose cannonsfrom fouling their precisely ordered wo...

Research on Worms Yields Clues on Aging

...e researchers grew the roundworm C. elegans in the presence of the 19drugs and found that an anticonvulsant, ethosuximide, extended theworms' lives from an average of 17 days to an average of 20 days.Further tests on anticonvulsants revealed that they also increased lifespan, with the drug trimethadione havin...

Novel Enzyme Shows Potential As An Anti-HIV Target

...n to show that transcription via Tat occurs in the presence of SIRT1, but not when SIRT1’s catalytic center is removed. Experiments using cells taken from transgenic mice lacking SIRT1 demonstrated that introducing human SIRT1 enzymes increased Tat’s transcriptional effects in a dose-dependent manner, while t...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...ed a combination of antibodies and dyes toshow the presence of neurotransmitters in single neurons. "We'veactually taken superlative three-dimensional pictures where we go rightthrough the embryo," says Reinisch. The sequence of images yields athree-dimensional representation of the embryos' developing neuron...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...ed a combination of antibodies and dyes toshow the presence of neurotransmitters in single neurons. "We'veactually taken superlative three-dimensional pictures where we go rightthrough the embryo," says Reinisch. The sequence of images yields athree-dimensional representation of the embryos' developing neuron...

An HIV Protein Plays a Surprising Role in Gene Activation

... TAFs studied appeared. None of them did so in the presence of Tat, suggesting that Tat-mediated HIV transcription doesn't rely on TAFs. Green and colleagues confirmed this hypothesis in experiments showing that Tat-driven transcription proceeded as usual in cells lacking TAFs. And they demonstrated that it i...

A bacterial genome reveals new targets to combat infectious disease

...em. One discovery of possible significance is the presence in the bacterium of the synthetic pathway for heme - the oxygen-carrying iron component of hemoglobin. The nematode may require heme for synthesis of developmental hormones, so Wolbachia's heme pathway may be an inviting target for therapy against ne...

Scientists rid stem cell culture of key animal cells

...nt, for instance. Unexpectedly, Xu found that the presence of serum replacement promoted stem cell differentiation. Digging deeper, he found that serum replacement mimics the activity of bone morphogenetic protein (BMP), a molecule known to kick-start embryonic development, or in this case, cell differentiat...

Study shows nanoshells ideal as chemical nanosensors

...aman enhancement is an aggregateeffect, due to the presence of localized "junctions" or "hot spots"between metallic regions of the metallic film substrate.The finding that individual nanoshells can vastly enhance the Ramaneffect opens the door for biosensor designs that use a singlenanoshell, something that c...

Development of portable infectious disease detector

...'s homepregnancy tests that can quickly detect the presence of infectiousdiseases, including HIV-AIDS and meas... aresingle purpose. That is, they can identify the presence of a singletoxin, or a limited number of closely related toxins. The ability tomonitor the health of...

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