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Tag: "predispose" at biology news

Research team identifies new Alzheimer's gene

...es” To date, the most significant gene found to predispose an individual to late onset Alzheimer’s (LOAD) has been APOE4. In this latest study, researchers from seven organizations contributed to the genome-wide scan using Affymetrix microarray technology. The team screened the DNA from 1,400 individuals who...

Common treatment for methamphetamine overdose may damage brain cells

...ells in one part of the substantia nigra. This may predispose some people who have been treated for a methamphetamine overdose to seizures and the development of movement disorders, they say, although the study did not measure movement specifically. In addition to future studies of other antipsychotic medic...

Genetic fingerprints identify brain tumors' origins

...ce any solid leads on the genetic alterations that predispose children to PAs. "It should be recognized that the genetic alterations in this tumor may be very subtle," Gutmann notes. "When we looked at gene activity levels in the tumors as a function of brain location, though, a very interesting pattern bega...

Good behavior, religiousness may be genetic

... these behaviors also because there are genes that predispose them to it." "There is, of course, no specific gene for religiousness, but individuals do have biological predispositions to behave in certain ways," says Koenig. "The use of twins in the current study allowed for an investigation of the genetic a...

New protein implicated in autism

...e suggestion that defects in CADPS2 function might predispose individuals to develop autism. ...

Fruit fly gene research may shed light on human disease processes

...different forms, called alleles, some of which may predispose an individual to a disease." "Studying the common fruit fly ?Drosophilia melanogaster -- lets us conduct more sophisticated experiments than can be undertaken in humans. These simple organisms can be grown cheaply in test tubes, fed on yeast, corn...

Altered perception of reward in human cocaine addiction

...nt to inhibit inappropriate behavior, and may also predispose these individuals to disadvantageous decisions -- for example, trading a car for a couple of cocaine hits. Without a relative context, drug use and its intense effects -- craving, anticipation, and high -- could become all the more overpowering," she...

Scientists work to identify genes that contribute to early heart attack risk

...om the study looking for genetic variants that may predispose individuals to develop early atherosclerosis. "Perhaps the most remarkable thing about this study is the large number of genetic variants that we’re going to study," said Herrington. "Using special technology provided by Perlegen Sciences, we will...

Inheriting a tendency to brain infection

...asanova believes there are likely other genes that predispose people to infectious diseases, and that some of them may be inherited in a dominant fashion. That is, an individual need inherit only one copy of the mutation to show the predisposition. In his opinion, scientists will increasingly need to view commo...

A sweet solution for Alzheimer's disease?

...sted them in transgenic mice with human genes that predispose them to an Alzheimer's-like disease. When the researchers treated these mice with scyllo-inositol, all of the animals' disease symptoms improved. Cognitive function was improved, amyloid plaques disappeared, inflammation declined, and the mice live...

New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds

...)-1. The researchers showed that this drug did not predispose the animals to thrombosis or elevate blood pressure. ...

Therapeutic prospects beyond Vioxx

...ntrast to deletion or inhibition of COX-2, did not predispose the animals to thrombosis or elevate blood pressure. A clue to this surprising finding was that while mPGES-1 deletion suppressed profoundly another product of the COX-2 pathway called PGE2, the deletion of mPGES-1 actually elevated prostacyclin, the...

Alcoholism, smoking and genetics among Plains American Indians

...kers and heavy drinkers, indicates that some genes predispose individuals to both smoking and drinking," said Mary-Anne Enoch, a staff scientist in the Laboratory of Neurogenetics at the National Institute on Alcohol Abuse and Alcoholism and corresponding author for the study. "Nicotine's effects on the brain ...

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

...art Study, U.S.A., have identified a gene that may predispose some people to abnormal heart rhythms that lead to sudden cardiac death, a condition affecting more than 300 thousand Americans each year. The gene called NOS1AP, not previously flagged by or suspected from more traditional gene-hunting approaches,...

Do the Europeans turn ill sitting up so late?

...ecrease in the quality of life.Sleep loss may also predispose individuals to conditions such as burn-out and cardiovascular diseases. The EU has granted a 4,4 million Euro funding for this research project from the Marie Curie 6th Framework Program. In addition to Finland there are partners from UK, Belgium, G...

Shade trees getting 'scorched' by plant disease

...vironmental stresses such as drought. BLS may also predispose infected plants to other disease and insect problems. Practice sanitation. Branches that have died due to BLS should be routinely removed. Infected trees that are in a severe state of decline should also be removed. Use tolerant plants. In areas w...

Biologists Crack Genetic Code for Specialized Spider Silk

...tibodies. Furthermore, IgA deficiency and CVID can predispose to autoimmune diseases, where the immune system turns against the body’s own tissues and organs. “Most cases of CVID and IgA deficiency are of unknown cause,?notes Josiah Wedgwood, M.D., Ph.D., of the Clinical Immunology Branch of the National Insti...

Agreement will speed research on microbicides for women

...tibodies. Furthermore, IgA deficiency and CVID can predispose to autoimmune diseases, where the immune system turns against the body’s own tissues and organs. “Most cases of CVID and IgA deficiency are of unknown cause,?notes Josiah Wedgwood, M.D., Ph.D., of the Clinical Immunology Branch of the National Insti...

Defective Gene Linked to Two Inherited Immune Deficiencies

...tibodies. Furthermore, IgA deficiency and CVID can predispose to autoimmune diseases, where the immune system turns against the body’s own tissues and organs. “Most cases of CVID and IgA deficiency are of unknown cause,?notes Josiah Wedgwood, M.D., Ph.D., of the Clinical Immunology Branch of the National Insti...

Protein amplification in melanoma is possible drug target

...cy and CVID can occur in the same family, and also predispose people to autoimmunity, particularly affecting the thyroid gland and resulting in thyroid hormone insufficiency. Finally, people with CVID are susceptible to B-cell lymphomas. The researchers, led by Raif Geha, MD, and Emanuela Castigli, PhD, in the...

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