Gene Expression in the Aging Brain
... DNA in which genes are encoded, and so the theory predicts that the most metabolically active tissues should show the greatest age-related reduction in gene expression. In this issue, Michael Eisen and colleagues show that the human brain follows this pattern. A similar pattern—which, surprisingly, involves ...Mining biotech's data mother lode
...ard techniques.A second analysis tool in the suite predicts what possible protein-protein interactions are taking place. This is novel. When a gene encodes a protein, the protein folds up into a unique shape, forming a 3D structure. This structure can only interact, or fit, with some proteins, but not others,...Breaking the mold: Research teams sequence three fungus genomes
...ey become more prevalent in the aging population," predicts first author William Nierman, a microbiologist at TIGR. Nierman co-authored two additional Aspergillus genome papers in the same issue of Nature. One describes a genome project on Aspergillus oryzae , a nonpathogenic food industry workhorse that ...Fish evolve a longer lifespan by evolving a longer reproductive period, researchers find
...ase in their reproductive lifespan. Indeed, theory predicts this result because only reproductive lifespan determines fitness." Study results appear Dec. 27 in the online edition of the Public Library of Science ?Biology. The study supports the controversial hypothesis that natural selection ?the process i...Biotechnology's newest chemical tool
...ne thought it was possible,' said Klimasauskas. He predicts that DNA methyltranferases will become a standard laboratory tool like restriction endonucleases. Earlier studies had suggested that the transfer of chemical groups larger than a methyl group would not be possible, in part because replacing AdoMet's...Immune system has evolved to prevent autoimmune disease
...al nature of the body's immune response. The model predicts that chronic infections may lead to autoimmune diseases, a scenario that has been proposed as a cause of some rheumatic diseases like arthritis. "There are as many as a 100 million unique antibodies circulating through our bodies at any given time, ...Eleven gene 'signature' reliably predicts cancer prognosis
...exists in a very malignant subset of human cancers predicts a marked predisposition toward metastasis and a high probability of poor therapy outcome. In an accompanying commentary, Gordon Mills and others write, "such a "magic marker" [will] have a major impact on patient care." TITLE: Microarray analysis id...Birds and bats sow tropical seeds
...-- will attract additional funding sources. And he predicts close academic collaboration between UNAM and U.S. ecology programs like UIC's. "It will involve environmental issues which will occupy a great many students," he said. "These students will disperse through Mexico and the rest of Latin America. We h...Computer modeling reveals hidden conversations within cells
...rchers report that their computer model accurately predicts particular behaviors of living cells. They also believe that the model has important practical applications, including guiding the design of better treatments for cancer and other diseases that involve failures in cell communication "Our computatio...Computers close in on protein structure prediction
...rect shape in cells, but one oft-repeated estimate predicts it would take longer than the age of the universe for a computer to sample all the possible confirmations of a folded protein. Baker's lab already receives help from supercomputing centers in San Diego and Illinois. More help will soon be on its wa...A Father’s Day Gift: Free DNA Paternity Testing
...st research is still purely scientific, the report predicts that the promise of important new products will lead to an increase in commercial exploration. The report cites the need to prevent harm from research in deep seabed areas, especially those particularly sensitive to disturbances such as cold seeps a...Clear rules needed to govern deep sea bioprospecting: UNU
...st research is still purely scientific, the report predicts that the promise of important new products will lead to an increase in commercial exploration. The report cites the need to prevent harm from research in deep seabed areas, especially those particularly sensitive to disturbances such as cold seeps a...Researchers identify genes associated with lung transplant rejection
... care. Another potential benefit of the research, predicts Caughey, will be a better understanding of lung rejection at the genetic level. In turn, he believes, this could lead to the development of medications that directly target genes responsible for the scarring process in the lung, instead of anti-rejec...Tufts researchers shine light on firefly mysteries
...iences. "On the other hand, sexual conflict theory predicts that male signals may evolve to provide uninformative or even misleading cues about male quality." Funded by the National Science Foundation and a Tufts Faculty Research Award, such research may ultimately help further our understanding of human com......deciding if the information coming from the senses predicts the sugar reward and signaling to the muscles to take the appropriate action to receive the reward. Computer models of how a bee assimilates and responds to information about a reward can be then applied to studies of how humans make decisions about...Caloric restriction won't dramatically extend life span in humans: UCLA research
... slope isn't very steep," said Phelan, whose model predicts the relationship between calories consumed and life span. Phelan's conclusion is that the few extra years of life are not worth the suffering necessary to achieve them. "Do you want to spend decades severely limiting what you eat to live a few more...Program finds lost genes in nematode genome
...ed with the use of TWINSCAN predictions. And Brent predicts that the age of the human genome annotator is passing ?the future belongs to computer-driven annotation. Crossing the tipping point "We've crossed the tipping point with gene prediction where it's becoming clear that machines can beat human annotat...Genome study of beneficial microbe may help boost plant health
...genome paper and an expert on P. fluorescens Pf-5, predicts that the new genomic data will help scientists more quickly develop new ways to boost the effectiveness of beneficial microbes in fighting plant diseases. "This genomic sequence reveals previously unknown traits of P. fluorescens that increase its p...Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
... computational ally ?a mathematical algorithm that predicts the precise effects a given compound will have on a cell’s molecular components or chemical processes. Using this tool, drug developers can design compounds that will act on only desired gene and protein targets, eliciting therapeutic responses free ...Radio-tracking associated with 'dramatic shift' in water vole sex ratio
...f the local resource competition hypothesis, which predicts that mothers with access to poor resources will produce offspring of the sex most likely to disperse and therefore reduce local competition for resources. "Radio-collars clearly have the potential to cause some stress to water voles, and it is possi...