Researchers find cause of frontotemporal dementia
... a shortage of this growth factor. The new finding predicts that progranulin might also play a role in other types of brain diseases in which brain cells die off ?such as Alzheimer's disease and Parkinson's disease. Frontotemporal dementia After Alzheimer's, frontotemporal dementia is the most prevalent f...Cells use mix-and-match approach to tailor regulation of genes
...nd indirect evidence to create a model. That model predicts 980 as-yet-undiscovered transcription factor-gene binding interactions. "This 'systems biology' approach, using so many different lines of evidence, has given us a much more revealing and detailed picture of how cells orchestrate gene regulation to ...On the track of tiny larvae, a new model elucidates connections in marine ecology
...researchers coupled two types of models: One model predicts the movements of "virtual" coral larvae in the Caribbean Sea based on ocean currents, while the second model gives the virtual larvae a genetic tag. The researchers then tested this new approach by comparing the new model's predictions to empirical g...Rehydrate -- your RNA needs it
...ave focused on one particular ribozyme, but Walter predicts the findings will apply to other RNAs. If so, those findings should be of great interest to scientists who are learning more all the time about the diverse roles of RNA. Once thought to be only a passive carrier of encoded genetic information, RNA is...How can identical twins be genetically different?
...y one twin will have health problems when genetics predicts both of them should. Scientists at the University of Michigan Medical School are just beginning to understand how two people who are so similar biologically can be so different when it comes to the development of diseases like rheumatoid arthritis....Even fish don't swim well when they're young!
...ladder, so similar problems could occur for them", predicts Müller. This conclusion is all the more profound because it refutes two previous theories of poor hatchling swimming, one focusing on the burst phase and the other on the coast.The former of the two explanations suggests that because the larvae are ...Anti-inflammatory drug's potentially deadly side effect found to be rare
...h has to be injected on a monthly basis. Clifford predicts that his group's report and the other studies of natalizumab will be important elements in "lively" discussions to be held by the Food and Drug Administration regarding the future of this therapy. "Patients with MS are eager to access more effectiv...AIDS-related cognitive impairment exists in two separate forms
...tinct "signature" in the expression of miRNAs that predicts colon cancer. Scientists have only recently discovered that miRNAs, which are tiny snippets of single-stranded RNA, can regulate the expression of genes, and thus regulate protein synthesis that affects cellular pathways. Because of this ability to...Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers
...tinct "signature" in the expression of miRNAs that predicts colon cancer. Scientists have only recently discovered that miRNAs, which are tiny snippets of single-stranded RNA, can regulate the expression of genes, and thus regulate protein synthesis that affects cellular pathways. Because of this ability to...Common molecular 'signature' identified in solid tumors
...g growth factor, beta receptor 2 (TGFBR2). Croce predicts that miRNAs themselves may one day be used as treatments. "If we can replace miRNAs that are lost and block those that are overly abundant, then maybe we can prevent some of the very earliest changes that happen in the development of cancer. There is...Poison dart frog mimics gain when birds learn to stay away
... The result is surprising, because mimicry theory predicts that when all three frogs occur in the same forest, the mimics would look like the more toxic frog species, the more abundant of the toxic frogs, or look like both the more and less toxic species. "We've uncovered a new mechanism involved in mimicry...Researchers discover way to transport environmental arsenic to plant leaves in new clean-up strategy
...oblem is vast. The World Health Organization (WHO) predicts that long-term exposure to arsenic could reach epidemic proportions, the PNAS paper reports. The WHO says a staggering 1 in 10 people in northern India and Bangladesh may ultimately die of diseases resulting from arsenic-related poisoning. The new s...Spring migration of pink-footed geese under threat
...d individuals. According to Klaassen: "The model predicts that if scaring on a large scale is implemented abruptly, it will have severe consequences for the population because the geese will not have time to adjust their behaviour to their dramatically changed environment. We are already seeing signs of dec...Carnegie Mellon scientists show brain uses optimal code for sound
...ple theoretical account of the auditory code which predicts how we could optimize signal processing to one day allow for much more efficient data storage on everything from DVDs to iPods," Lewicki said. "For instance, if we could use a cochlear implant to 'talk' to the auditory nerve in a more natural way v...Common molecular 'signature' identified in solid tumors
...g growth factor, beta receptor 2 (TGFBR2). Croce predicts that miRNAs themselves may one day be used as treatments. "If we can replace miRNAs that are lost and block those that are overly abundant, then maybe we can prevent some of the very earliest changes that happen in the development of cancer. There is......It's going to be virtually impossible to control," predicts David Magnus, director of the Stanford Center for Biomedical Ethics in Palo Alto, California. Endy argues that what's needed is better self-regulation: ifresearchers only do business with companies that are diligent in sequence screening and othersec......otif. Now the lab will expand the method; Russell predicts that hundreds of linear motifs remain to be discovered. This has important implications for the study of genetic diseases. "A lot of work has gone into discovering mutations that affect protein binding," he says. "Because linear motifs are so small, ...Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
... DNA in which genes are encoded, and so the theory predicts that the most metabolically active tissues should show the greatest age-related reduction in gene expression. In this issue, Michael Eisen and colleagues show that the human brain follows this pattern. A similar pattern—which, surprisingly, involves ...Looking for the genes that affect a person's level of response to alcohol
...ore likely to occur in children of alcoholics, and predicts a greater risk for alcohol problems. A study in the November issue of Alcoholism: Clinical & Experimental Research has found that a gene on chromosome 10 ?in particular, the KCNMA1 gene ?is potentially linked to LR. "The LR to alcohol is a g...Navigating the brain for sense of direction as paradigm for higher cognitive functions
... DNA in which genes are encoded, and so the theory predicts that the most metabolically active tissues should show the greatest age-related reduction in gene expression. In this issue, Michael Eisen and colleagues show that the human brain follows this pattern. A similar pattern—which, surprisingly, involves ...