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Tag: "predictive" at biology news

Gene variations explain drug dose required to control seizures

...macogenetics, a center of the IGSP. If the genes' predictive value is verified in clinical trials, such a "pharmacogenetic" approach might make it possible to safely reduce the time required for patients with epilepsy and their physicians to reach an effective dose of the medications that control seizures, sai...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

...ed outcomes before testing them experimentally.The predictive capabilities of computer simulations can also aidbiologists in viewing cellular activity over a period of time, bytaking advantage of the power of computers to generate the thousands ofpotential protein complexes and reactions that cells are able tog...

Chemists identify key gene in development of type 1 diabetes

...rs ?either antibodies or genetic markers ?that are predictive of the disease but are still able to produce insulin. Al-Abed and his associates hope that the experimental compound can one day be developed into a long-acting oral drug that could be taken by prediabetic people to achieve lasting protection, perha...

Towards precise classification of cancers based on robust gene functional expression profiles

...rs ?either antibodies or genetic markers ?that are predictive of the disease but are still able to produce insulin. Al-Abed and his associates hope that the experimental compound can one day be developed into a long-acting oral drug that could be taken by prediabetic people to achieve lasting protection, perha...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

...nostic tests, new diagnostics, targeted therapies, predictive therapeutic strategies and potentially preventative modalities for patients" said IGC’s founder, Daniel Von Hoff, MD, FACP. IGC has established a uniform system for obtaining and processing tissue samples for molecular characterization studies. Clin...

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

... pairs, and gene triplets, and found their model's predictive accuracy increased with gene number. They also looked for genes that showed different expression patterns over the two years based on patient response, time passed, and patient response over time. These analyses identified genes that increased activi...

Scientists identify molecule that regulates well-known tumor suppressor

...ates, as it has also been recently identified as a predictive diagnostic for early-onset, autosomal recessive Parkinson's disease. The other members of the research team include Raymond H. Kim, YingJu Jang, and Tak W. Mak of Ontario Cancer Institute and University of Toronto; Malte Peters, Carmela DeLuca, Jenn...

Small species back-up giant marsupial climate change extinction claim

...luence on the extinction of species, it might have predictive value in estimating the effects of possible future climate changes and its impacts on modern species." Megafauna roamed the globe in the Pleistocene epoch, between 1.8 million and 10,000 years ago. In the northern hemisphere species such as the woo...

Biomarkers isolated from saliva successfully predict oral and breast cancer

...hed in Clinical Cancer Research, disclosed similar predictive powers for head and neck cancers. "These results ...ic profiles," said Wong. "The risk model yielded a predictive power of 95 percent by using only the salivary transcriptome samples and 88 percent by using only se...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...o respond to treatment even when existing clinical predictive criteria point towards a positive treatment outcome. The research, published in the April issue of Cancer Cell, is likely to facilitate development of new strategies to combat drug resistance and treatment failure for children with ALL. Nearly 80% o...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...ve use of Tarceva," he says. The only experimental predictive test currently available is whether lung cancer cells have a mutation in their epidermal growth factor receptor (EGFR), but that does not predict response to the targeted therapy in other forms of cancer, Ueno says. "We find here that as long as CDK...

Remote control flies? Fly behavior controlled by laser light

...euroscience from passive observation…to active and predictive manipulation of behavior," the Cell authors write. Miesenböck also says "one could use this method to restore neural signals that have been lost" due to injury or disease, such as in spinal cord trauma, although he notes that the possibility is "far...

Study shows humans have ability to track odors, much like bloodhounds

...erall," Sobel said. "So the fact that we have this predictive value in the data really suggests that we have actually successfully captured the mechanism." What's more, another area of the brain outside the olfactory cortex was very active during successful localization. This area, the superior temporal gyrus,...

Rensselaer researchers develop approach that predicts protein separation behavior

...formation from lab analysis and concentrates it in predictive models that may be evaluated on a computer," said Curt M. Breneman, professor of chemistry and chemical biology at Rensselaer. "The ability to predict the separation behavior of a particular protein directly from its structure has considerable impli...

Retina adapts to seek the unexpected, ignore the commonplace

...enes. Scientists had interpreted this as a form of predictive coding, a strategy shaped by the forces of evoluti...environment. These changes are adaptive, improving predictive coding by enhancing the ability of these receptive fields to pick out unusual features." While mani...

Learning how SARS spikes its quarry

... needed -- if a new virus were isolated -- to make predictive guesses about infectivity, so that we can better give advance warning." He also noted that laboratory studies indicate that the fragment of the spike protein they used could provide the basis of a vaccine against SARS, since it appears to be recogn...

Grand Challenges in Global Health initiative funds Yale project

...th Initiative for providing the funds to develop a predictive model system for vaccine testing." Yale School of Medicine Dean Robert Alpern, M.D., said, "This generous grant from the Grand Challenges in Global Health Initiative provides a boost to Yale's ongoing initiatives in basic science and clinical resear...

Researchers use brain scans to predict behavior

...se to you." Sapir noted that the reward systems' predictive abilities may be damaged or missing in some patients with mental illness, causing these patients to perceive the world as alien and unpredictable. Other areas involved in prediction included regions in the visual cortex involved in the analysis of ...

Center releases new public survey on stem cells

...ted as an all-or-nothing proposition that is fully predictive of all of an individual's other views on embryonic stem cell research, the public's views about the moral status of embryos and the relationship of those views to ESC research policy preferences has not been fully explored. The survey showed that ne...

Microarray technology for tailoring breast cancer therapy

...and poor prognoses.The researchers then tested the predictive value of the group of 64 genes compared with three currently used clinical markers. Using the expression patterns of the 64 genes identified by the researchers gave significantly better(P=0.007) prediction rates than histological grading, tumour stag...

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