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Tag: "precursor" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...ry low-density lipoprotein (VLDL) cholesterol, the precursor of low-density lipoprotein (LDL) cholesterol (known as the "bad" form of cholesterol) and triglycerides ?another fatty substance ?that are secreted into the bloodstream. PGC-1beta belongs to a specific family of co-activators, proteins that interact...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...like growth factor 2 (IGF2) develop more so-called precursor cells within the lining of the colon than normal m..., everything is pretty normal except for the extra precursor cells," says Christine Iacobuzio-Donahue, M.D., assistant professor of pathology and oncology. "But ...

Neuronal 'traffic jam' marks early Alzheimer's disease

...derlies Alzheimer's pathology, called beta amyloid precursor protein (beta-APP), triggers defects in axonal transport. A defective version of beta-APP is cleaved to form an aberrant form of amyloid beta (A-beta) peptide that makes up the plaques that surround the neurons of people with Alzheimer's disease. "W...

Scientists identify new model Of NK cell development

...upport their beliefs, they first identified the NK precursor cell, then, they measured the number of the precur...uthor of the study, discovered that these novel NK precursor cells are not randomly strewn throughout the lymph nodes, but rather localized near special sites ca...

Disease diagnosis, biodefense among UH chemical research projects

...terning of conjugated polymer ultrathin films: The precursor polymer approach." # Steven Baldelli, assistant professor of chemistry, will present research with applications in batteries and fuel cells. His paper is titled "Surface spectroscopy of room-temperature ionic liquids at the platinum-liquid electroch...

Brain-injury rehabilitation depends on acetylcholine circuitry

...rtical representations will likely be an important precursor for designing therapeutic strategies to enhance functional recovery following nervous system injury," the researchers wrote. "The present study makes a significant contribution toward this goal by identifying the basal forebrain cholinergic system as...

Gene keeps neural cells on correct developmental path

... rest of the body's cells. Now, it turns out that precursor nerve cells contain that same repressive protein a...ull elaboration of the neuronal phenotype from the precursor cell." Led by HHMI associate Nurit Ballas, a postdoctoral fellow in Mandel's lab, the study may adv...

Combination therapy leads to partial recovery from spinal cord injury in rats

...ors from the spinal cords of embryonic rats. These precursor cells develop from stem cells and are specialized ...Whittemore and his colleagues injected the treated precursor cells into the spinal cords of rats with a type of spinal injury called a contusion, which is caused...

Researchers extend mouse lifespan by protecting against free radicals

... a waste product of metabolism and it can be a the precursor of free radicals that can damage the cell. The damage can in turn lead to more flaws in the cell's chemical processes, making a vicious cycle that leads to more free radicals, more cellular damage, and so on. The researchers studied mice with a gene...

Pinpointing the cause of a neurodegenerative disorder

...that causes Parkinson's disease, or of the amyloid precursor protein that causes Alzheimer's disease, can cause pathology," she said. "So, this raises the question of whether mutations in the genes for these proteins enhance their normal action. "Importantly, such insights can now guide studies that focus on ...

VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease

...st cells are believed to be generated by different precursor cells in the bone marrow. In the in vitro portion... that give rise to mast cells. They cultured these precursor cells in conditions that allow mast cells to develop, and then added IFNγ to some of these cult...

Climate model links higher temperatures to prehistoric extinction

...st cells are believed to be generated by different precursor cells in the bone marrow. In the in vitro portion... that give rise to mast cells. They cultured these precursor cells in conditions that allow mast cells to develop, and then added IFNγ to some of these cult...

Pinpointing a culprit molecule in Alzheimer's disease

...ically altered to overproduce mutant human amyloid precursor protein (APP). It is this protein that, when clipped by enzymes, produces the amyloid beta (Ab) peptide that clusters into the amyloid plaque that clogs the brain and kills brain cells. The clipping of APP produces two types of amyloid beta peptide-...

Bacteria are key to 'green' plastics, drugs

Engineered bug makes key chemical precursor from grain sorghum Trials have begun in Kansas on a "green" production method for succinate, a key ingredient of many plastics, drugs, solvents and food additives. Developed at Rice University, the technology uses a genetically modified form of the ...

'Jumping genes' contribute to the uniqueness of individual brains

...o-called LINE-1 or L1 element in cultured neuronal precursor cells from rats. Then they introduced it into mice...s. The Salk team found insertions only in neuronal precursor cells that had already made their initial commitment to becoming a neuron. Other cell types found in...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...plaques are formed when enzymes cleave the amyloid precursor protein (APP) releasing the toxic beta amyloid fragments that clump together to form the sticky plaques. One of the enzymes doing the cleaving is called beta secretase or BACE1. And although the production of beta amyloid occurs in all brains, healt...

The making of a fat cell

...ding bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes. "The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene...

System Drastically Cuts Down Botulism Detection Time

...ding bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes. "The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene...

Short-term Bio Sensors Monitor From Afar

...ding bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes. "The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene...

Key To Stem Cell Transplant Success Is Tricking Immune System

...ding bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes. "The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene...

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