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Tag: "precursor" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...ry low-density lipoprotein (VLDL) cholesterol, the precursor of low-density lipoprotein (LDL) cholesterol (known as the "bad" form of cholesterol) and triglycerides ?another fatty substance ?that are secreted into the bloodstream. PGC-1beta belongs to a specific family of co-activators, proteins that interact...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...like growth factor 2 (IGF2) develop more so-called precursor cells within the lining of the colon than normal m..., everything is pretty normal except for the extra precursor cells," says Christine Iacobuzio-Donahue, M.D., assistant professor of pathology and oncology. "But ...

Neuronal 'traffic jam' marks early Alzheimer's disease

...derlies Alzheimer's pathology, called beta amyloid precursor protein (beta-APP), triggers defects in axonal transport. A defective version of beta-APP is cleaved to form an aberrant form of amyloid beta (A-beta) peptide that makes up the plaques that surround the neurons of people with Alzheimer's disease. "W...

Scientists identify new model Of NK cell development

...upport their beliefs, they first identified the NK precursor cell, then, they measured the number of the precur...uthor of the study, discovered that these novel NK precursor cells are not randomly strewn throughout the lymph nodes, but rather localized near special sites ca...

Disease diagnosis, biodefense among UH chemical research projects

...terning of conjugated polymer ultrathin films: The precursor polymer approach." # Steven Baldelli, assistant professor of chemistry, will present research with applications in batteries and fuel cells. His paper is titled "Surface spectroscopy of room-temperature ionic liquids at the platinum-liquid electroch...

Brain-injury rehabilitation depends on acetylcholine circuitry

...rtical representations will likely be an important precursor for designing therapeutic strategies to enhance functional recovery following nervous system injury," the researchers wrote. "The present study makes a significant contribution toward this goal by identifying the basal forebrain cholinergic system as...

Gene keeps neural cells on correct developmental path

... rest of the body's cells. Now, it turns out that precursor nerve cells contain that same repressive protein a...ull elaboration of the neuronal phenotype from the precursor cell." Led by HHMI associate Nurit Ballas, a postdoctoral fellow in Mandel's lab, the study may adv...

Combination therapy leads to partial recovery from spinal cord injury in rats

...ors from the spinal cords of embryonic rats. These precursor cells develop from stem cells and are specialized ...Whittemore and his colleagues injected the treated precursor cells into the spinal cords of rats with a type of spinal injury called a contusion, which is caused...

Researchers extend mouse lifespan by protecting against free radicals

... a waste product of metabolism and it can be a the precursor of free radicals that can damage the cell. The damage can in turn lead to more flaws in the cell's chemical processes, making a vicious cycle that leads to more free radicals, more cellular damage, and so on. The researchers studied mice with a gene...

Pinpointing the cause of a neurodegenerative disorder

...that causes Parkinson's disease, or of the amyloid precursor protein that causes Alzheimer's disease, can cause pathology," she said. "So, this raises the question of whether mutations in the genes for these proteins enhance their normal action. "Importantly, such insights can now guide studies that focus on ...

VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease

...st cells are believed to be generated by different precursor cells in the bone marrow. In the in vitro portion... that give rise to mast cells. They cultured these precursor cells in conditions that allow mast cells to develop, and then added IFNγ to some of these cult...

Climate model links higher temperatures to prehistoric extinction

...st cells are believed to be generated by different precursor cells in the bone marrow. In the in vitro portion... that give rise to mast cells. They cultured these precursor cells in conditions that allow mast cells to develop, and then added IFNγ to some of these cult...

Pinpointing a culprit molecule in Alzheimer's disease

...ically altered to overproduce mutant human amyloid precursor protein (APP). It is this protein that, when clipped by enzymes, produces the amyloid beta (Ab) peptide that clusters into the amyloid plaque that clogs the brain and kills brain cells. The clipping of APP produces two types of amyloid beta peptide-...

Bacteria are key to 'green' plastics, drugs

Engineered bug makes key chemical precursor from grain sorghum Trials have begun in Kansas on a "green" production method for succinate, a key ingredient of many plastics, drugs, solvents and food additives. Developed at Rice University, the technology uses a genetically modified form of the ...

'Jumping genes' contribute to the uniqueness of individual brains

...o-called LINE-1 or L1 element in cultured neuronal precursor cells from rats. Then they introduced it into mice...s. The Salk team found insertions only in neuronal precursor cells that had already made their initial commitment to becoming a neuron. Other cell types found in...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...plaques are formed when enzymes cleave the amyloid precursor protein (APP) releasing the toxic beta amyloid fragments that clump together to form the sticky plaques. One of the enzymes doing the cleaving is called beta secretase or BACE1. And although the production of beta amyloid occurs in all brains, healt...

The making of a fat cell

...ding bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes. "The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene...

System Drastically Cuts Down Botulism Detection Time

...ding bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes. "The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene...

Short-term Bio Sensors Monitor From Afar

...ding bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes. "The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene...

Key To Stem Cell Transplant Success Is Tricking Immune System

...ding bone, cartilage, muscle, nerve, and fat. Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes. "The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene...

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(Date:4/22/2014)... Consortium Ltd.,s nanotechnology expert will present a poster ... at the 7th International Nanotoxicology Congress to ... , Dr. Monita Sharma will outline a strategy consistent ... of Sciences, " Toxicity Testing in the 21st Century: ... of non-animal methods involving human cells and cell lines ...
(Date:4/22/2014)... University of Kentucky has discovered new methods to build ... The research, led by Peixuan Guo, professor and ... College of Pharmacy and Markey Cancer Center, is reported ... Polymer Material To Build Robust Structures with Defined Shape ... L. Jasinski. , The article, which will appear in ...
(Date:4/22/2014)... Many research projects study the effects of temperature and ... species. However, an important component of climate research, the ... UFZ in collaboration with their colleagues from the Universities ... data from the U.S. NASA space agency in such ... the influence of UV-B radiation on organisms. , The ...
Breaking Biology News(10 mins):RNA shows potential as boiling-resistant anionic polymer material for nanoarchitectures 2UV-radiation data to help ecological research 2
(Date:4/23/2014)... of Alzheimer,s disease has been a rapidly evolving ... the latest crook in the research road, scientists ... between proteins associated with the disease. The report, ... Neuroscience , could have important implications for developing ... and colleagues explain that for years, research has ...
(Date:4/22/2014)... Jersey Institute of Technology (NJIT) today to join ... of the New Jersey Innovation Institute (NJII), an ... business innovation through the leveraging of industry, government, ... Cory Booker, Panasonic Corp. of North America Chairman ... Kim Guadagno, New Jersey Secretary of Higher Education ...
(Date:4/22/2014)... have characterized a set of clock genes that drive ... of species, from flies to humans. Over 15 mammalian ... are more. A team from the Perelman School of ... approaches could find them. , To accelerate clock-gene ... of Pharmacology and first author Ron Anafi, MD, PhD, ...
(Date:4/22/2014)... Researchers at UT Southwestern Medical Center are making breakthroughs ... , A team of physician-scientists at UT Southwestern ... hormone with natural anti-depressant properties) works inside the brain. ... for depression in the form of a neuroprotective drug ... online in April,s issue of Molecular Psychiatry, ...
(Date:4/22/2014)... (SACRAMENTO, Calif.) The risk of pregnancy among women ... sterilization is more than 10 times greater over a ... sterilization, a study by researchers at Yale University and ... in the medical journal Contraception , the study ... sterilization method marketed under the brand name Essure. ...
Breaking Medicine News(10 mins):Health News:Government and industry leaders herald launch of NJIT's New Jersey Innovation Institute 2Health News:Bioinformatics profiling identifies a new mammalian clock gene 2Health News:Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches 2Health News:Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches 3Health News:Risk of pregnancy greater with newer method of female sterilization 2Health News:Risk of pregnancy greater with newer method of female sterilization 3
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