Tag: "preclinical" at biology news

New licensing agreement to maximize AIDS drug development

... the U.S and Thailand and Cyanovirin-N which is in preclinical testing. Henry Gabelnick, Ph.D., executive director of CONRAD says, "This agreement is great news for everyone interested in developing an effective microbicide. The more partnerships we have like this one, the better our potential is for getting an ...

Potential vaccine developed for deadly leishmaniasis disease

... on one such malaria vaccine that is in late-stage preclinical trials. Other candidate vaccines against anthrax and tuberculosis are at an earlier stage of development. One major drawback with carbohydrate vaccines is the difficulty in getting them to produce a strong immune response. Vaccine manufacturers achi...

Both alcoholism and chronic smoking can damage the brain's prefrontal cortex

... project. He also will participate particularly in preclinical and human studies of the interface device with hand-and-arm surgeon Douglas T. Hutchinson, an associate professor of orthopaedics, and Nicholas Brown, a research assistant professor in orthopaedic surgery. Other University of Utah co-investigators ...

University of Utah to help build bionic arm

... project. He also will participate particularly in preclinical and human studies of the interface device with hand-and-arm surgeon Douglas T. Hutchinson, an associate professor of orthopaedics, and Nicholas Brown, a research assistant professor in orthopaedic surgery. Other University of Utah co-investigators ...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

... of therapeutic proteins currently in clinical and preclinical development, and additionally represent some of the largest selling products to emerge from the biotechnology industry. Monoclonal antibodies often achieve their therapeutic benefit through two binding events: 1) the binding of the variable domain of...

Mouse study reveals human X-SCID gene therapy poses substantial cancer risk

...after treatment, Woods says. "This indicates that preclinical experimental treatments involving transgenes shoul...to affect other genes, and that requires extensive preclinical work and a much more careful analysis," he says. X-SCID is caused by mutations in IL2RG, which prov...

Pain killer fights breast cancer by targeting key enzyme

...covery with nimesulide analogs, and a long path of preclinical research is needed before we can even begin to think about potential drugs." The researchers took several of these nimesulide analogs and, in laboratory cultures, tested their effects on estrogen-dependent breast cancer cells taken from human breast...

Swiss researchers develop all-in-one remote control gene expression tool

...lymorphic tool, useful in testing therapies and in preclinical studies," says Trono. "Using it we can control the gene expression in vivo in an extraordinary and sensitive way." ...

Preclinical study of a new brain tumor therapy

...y targeting and killing the malignant cells. A new preclinical study, published in the open access journal PLoS Medicine, has applied the approach to combat glioblastoma multiforme (GBM). This is the most aggressive form of brain tumour, growing very quickly before symptoms are experienced and killing most patie...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

...ondrin B (HB), which is a natural product shown in preclinical studies to have highly potent anti-cancer activity in vitro and in vivo. Halichondrin B was originally isolated from a type of marine sponge. This study was designed to evaluate E7389 as a monotherapy in patients with refractory breast cancer. The p...

Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection

...ecifically disrupt the CCR5 gene. In its anti-HIV preclinical research program, Sangamo has designed ZFNs that can be used to disrupt the CCR5 gene, a receptor required for HIV entry into immune cells. The researchers found that ZFN-modified cells were resistant to HIV infection whereas control cells were infe...

Compound from marine bacteria shows potential as multiple myeloma therapy

... ?and be better tolerated by patients as well. In preclinical studies, NPI-0052 blocks a wider range of proteasome activities than bortezomib, say the researchers, and works at lower doses. NPI-0052 also appears to be less toxic to normal cells. Bortezomib is currently given by intravenous infusion. "NPI-005...

Clinical trial to test stem cell approach for children with brain injury

...set the stage for larger-scale research. "All the preclinical data suggest this is a safe procedure with substantial information suggesting a possible treatment effect," Cox said. Because the children are receiving their own cells, an immunological response to the treatment is unlikely. Even marginal improv...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...ause such damage in the course of treatment. In preclinical work, Chang and her group found that the nanoparticle-p53 therapy enhanced chemotherapy and radiation treatment for cancer, pushing damaged cancer cells to die. They have also demonstrated that the nanocomplex goes only to cancer cells, leaving norma...

NIAID researchers show how promising TB drug works

...y, III, Ph.D., who headed the research team. In preclinical testing, PA-824 showed evidence of being effective against both actively dividing and slow-growing M. tb, giving rise to optimism that the compound may be useful in treating both active and latent TB. (For information about the first clinical trial o...

Biota makes major antiviral discovery

...ead candidate with a series of backups for further preclinical development prior to human clinical trials. RSV infection is an important medical need and already a billion-dollar market, with growing visibility among pharmaceutical companies. The currently marketed drug is an injectable antibody with 2004 sales...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

...s may one day be able to identify individuals with preclinical type 1 diabetes, and to assess the effectiveness of therapies much earlier than is now possible. Findings of the study will be published in the September issue of the Journal of Clinical Investigation. Type 1 diabetes is an autoimmune disease in whi...

Molecular miners find pain relief drugs from the sea

...s Limited recently announced successful results in preclinical trials of the toxin. The company will begin clinical trials in humans this month to firstly test the safety of the toxin in normal males, and later its effectiveness in treating the neuropathic pain associated with diabetes. From the University of M...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

...uthor, which demonstrated, for the first time in a preclinical model, that AAV could be a safe and effective vehicle for gene therapy in the brain. Most importantly, AAV has never been associated with any human disease. According to Drs. Kaplitt and During, "The goal of this research is to determine whether we...

New vaccine protects more effectively against tuberculosis

...gainst pulmonary tuberculosis has been achieved in preclinical studies. Importantly, the new vaccine also protects against clinical isolates of the Beijing family. These clinical isolates are frequently multi-drug-resistant and more aggressive and hence have started to conquer the globe. It has been assumed that...

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