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Tag: "precisely" at biology news

Priming embryonic stem cells to fulfill their promise

... constant and developed a miniaturizedtechnique to precisely vary extracellular matrix proteins as a way toidentify which combinations were optimal in producing differentiatedcells from stem cells," said Bhatia. She, Chien, and Flaim described intheir paper a technique that enabled them to identify the precise...

Fox Chase Cancer Center scientists identify immune-system mutation

...itment to the helper or killer lineages correlates precisely with the restriction of the T-cell receptor toward either class I or class II major histocompatibility complex (MHC) molecules. Most helper T cells carry a surface protein called CD4, which is attracted to class II MHC. Killer cells carry the CD8 pro...

Bound for destruction: Ubiquitination protects against improper Notch signaling

... prevent molecular loose cannonsfrom fouling their precisely ordered workplans....

New Clues Add 40,000 Years to Age of Human Species

... the 1967 expedition, the researchers were able to precisely locate the original fossil outcrops. The scientis... region to its moister climates of the past. But, precisely dating the outcrops required volcanic minerals with elements that undergo radioactive decay. Brown ...

Probing The Promise And Perils Of Nanoparticles

...of a human hair. Dendrimers have shown promise for precisely delivering drugs to their targets inside the body, but high concentrations of these nanoparticles can be toxic. In earlier work, U-M researchers discovered that dendrimers punch nanoscale holes in cell membranes, making the membranes more permeable. ...

International HapMap consortium expands mapping effort

...rs with a denser map that will enable them to more precisely narrow gene discovery to specific regions of the genome. The effort to expand the HapMap is made possible by $3.3 million in additional support from a unique public-private partnership, including the following organizations: the Wellcome Trust, Lond...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

...rved tissue allows the subsequent analysis to more precisely reflect the tumor’s biology. "We are very pleased with the significant successes the project has achieved in our first year,"?said Robert Penny, M.D., Ph.D, Executive Director of expO and Chief Medical Officer of IGC. "These findings will be of bene...

Probing the promise and perils of nanoparticles

...of a human hair. Dendrimers have shown promise for precisely delivering drugs to their targets inside the body, but high concentrations of these nanoparticles can be toxic. In earlier work, U-M researchers discovered that dendrimers punch nanoscale holes in cell membranes, making the membranes more permeable. ...

Advances in the characterisation of the oyster mushroom genes

... other is located on a different chromosome. It is precisely this fifth gene that is structurally distinct from the others: it lacks a fragment at its end. It should be pointed out that the genes that are together and the lone one are located on chromosomes where there are also genes responsible for the break...

Discovery may lead to better Candidiasis drug

...and a healthy immune system, but they did not know precisely how histatin accomplished this. "There are many types of naturally occurring proteins, such as venoms and toxins, that kill cells by creating holes in the cell membrane," said Edgerton, "but we thought that wasn't the case with histatin. We didn't t...

A new way to share models of biological systems

...vant data resources. This allows users to identify precisely the components of models, and helps them to retrieve appropriate models, which they can then visualize and build upon using any SBML-compatible software. "Ultimately," says Le Novère, "we hope that publishers will encourage any author who plans to p...

Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves

...t producing vital proteins for the healing? That's precisely where the molecular messengers, proteins called Erk-1 and Erk-2, enter the picture. When the axon is injured, these proteins bind to molecules of phosphorus. In this phosphorylated state, they can communicate to command centers in the cell, transmitt...

Purdue researchers use enzyme to clip 'DNA wires'

...searchers had previously developed a technique for precisely placing strands of DNA on a silicon chip and then stretching out the strands so that their encoded information might be read more clearly. The current work by Ivanisevic's team builds on that previous research. Kinsella created the magnetic particle...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...n medicine, harvested the embryonic pig tissues at precisely the right point in their development. "When we again harvested the transplant tissues 28 days after fertilization, it reproduced our earlier results, but if we moved the time of harvesting back to 35 days after fertilization, the rats rejected the p...

Team Invents Device For Weighing Individual Molecules

...ighter ones. Because frequency can be measured so precisely in physics labs, the researchers are then able to evaluate extremely subtle changes in mass of the nanodevice, and therefore, the weight of the added atoms or molecules. Roukes says that their current generation of devices is sensitive to added mass...

Malaria mechanism revealed

...s. (Image available on request) Next, to identify precisely which parts of the RII surface bind to glycophorin...malaria. (Image available on request) "We now see precisely how a key part of a malaria parasite protein works. This enables researchers to design very specific...

New Vaccine To Be Used For First Time In Polio Outbreak Response

... vaccine type 1(mOPV1). This new vaccine enables a precisely tailored immunological response to the type 1 poliovirus that is causing the outbreak. Compared to the commonly-used trivalent OPV, which offers protection against all three types of wild poliovirus, mOPV1 provides a greater immunity to type 1 wild p...

New tool reveals secrets of migrating cells

...rtex looking for the second test, which is to bind precisely to a protein called the major histocompatibility complex (MHC). These cells, the researchers think, are the meanderers. Only about one percent of thymocytes pass both tests, but Witt and Robey think that those that do are the ones they see beelining ...

Pinpointing a culprit molecule in Alzheimer's disease

...absence of overproduction of APP. Thus, they could precisely study the role of each of these molecules in AD pathology. Their studies of the mice revealed that the Ab40 mice showed little amyloid disease pathology in the animals' brains, while the Ab42 mice showed extensive accumulation of amyloid plaque and ...

Oxygen increase caused mammals to triumph, researchers say

...n the fossil samples allows scientists to estimate precisely how much oxygen was in the atmosphere at any given time, Falkowski says. From a steady 10 percent ?the level at which dinosaurs flourished ?the oxygen percentage rose to 17 percent 50 million years ago and then to 23 percent by 40 million years ago...

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