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Tag: "potent" at biology news

Secrets to antibody's success against West Nile Virus surprise scientists

...ile antibodies, scientists found that all the most potent antibodies bound to a particular section of a protein that makes up the exterior of the viral envelope. The envelope of a single viral particle or virion is comprised of 180 copies of this protein. For the new study, scientists determined the deta...

Stem cell training program to make its Stanford debut

...ariety of important biological processes. Some are potent cancer-fighting anti-oxidants, while others have antibiotic or anti-fungal properties. Many of these molecules only become active once they have had a prenyl group added. The researchers tested whether their new enzyme could modify a wide range of s...

Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure

...ariety of important biological processes. Some are potent cancer-fighting anti-oxidants, while others have antibiotic or anti-fungal properties. Many of these molecules only become active once they have had a prenyl group added. The researchers tested whether their new enzyme could modify a wide range of s...

Redesigned protein accelerates blood clotting

...cal Center, and the study's senior author. "A more potent form of factor VIII, one that could treat effectiv...und in healthy individuals," Fay said. "These more potent forms are not likely to occur naturally since they would theoretically result in excessive clotting,...

Retroviral resistance gene found

...l resistance gene, called FEZ1, that can mediate a potent resistance to murine leukemia virus, as well as HIV-1, in cell culture. The researchers found that the high level of FEZ1 expression in a specific laboratory rat cell line caused a significant block to retroviral infection ?retroviruses were able to ...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...t they have identified the biological pathway of a potent molecule that could delay rejection of transplanted organs by preventing blood-vessel deterioration. "One of the principal problems for kidney transplantation is organ availability," said Mark A. Atkinson, Ph.D., a study co-author and director of th...

Anthrax inhibitors identified by Burnham team

...compounds were synthesized and validated as highly potent and selective against LF in vitro. In in vitro ass...e compound with the goal of achieving an even more potent and selective drug that should exhibit a higher degree of protection against anthrax." This researc...

First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology

...ntinued Dr. Etches. "We expect the demand for more potent anti-cancer monoclonal antibodies and for lower production costs to increase at a rate that will tax existing cell culture production systems. The introduction of this new chicken-based production technology will be of considerable interest to an ind...

One hit of crystal meth causes birth defects

... reduced motor co-ordination. Methamphetamine is a potent and addictive stimulant. "We've known for a while that meth abuse during pregnancy is associated with low birth weight, cleft palates and other malformations but this is the first research demonstrating that even a single exposure can cause long-ter...

By creating molecular bridge, scientists change function of a protein

...til accepting the desired one -- corticosterone, a potent glucocoticoid. In total, Zhao and Chen did four rounds of random mutagenesis and screened about 1 million mutants before they found two estrogen receptor mutants that can be activated by corticosterone. The whole process was done in a couple of month...

Tamoxifen-like drug suggests new ways to selectively block estrogen

...en receptor down-regulators, or SERDs, have a more potent anti-estrogen effect, involving destabilization of the estrogen receptor, which leads to its degradation. GW5638 fits somewhere in the middle, acting like a SERM in some tissues and more like a SERD in others, including mammary tissue, where it is a...

Fungus Effective Against Winged Termites

...run faster than others, some fungi are simply more potent than others of their closely-related cousins. The researchers are currently seeking collaborators to further develop a formulation to deliver the fungal spores. They envision applying the fungus to buildings and trees already known to harbor termite...

Chemists synthesize molecule that helps body battle cancers, malaria

...onessential structures, leaving a simpler and more potent core. "One frequent problem encountered with vaccines is ensuring that the vaccine is potent enough to elicit a strong immune response," Gin said. "We will continue looking for ways to produce ...

Venom doc tracks down snake bioweapons

...is enabled snakes to develop more specific, highly potent toxins, ones that would cause their victims' bodies to turn against themselves upon injection. Over time, these newly derived toxins became a normal part of the saliva protein repertoire. To date, 24 different snake venom toxins have been characteriz...

Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights

...r, these compounds generate peroynitrate, a highly potent chemical that modifies many proteins. Unanue's group showed that this chemical modifies the peptides presented by antigen-presenting cells in several distinct ways. For example, they attach a nitrate group to the amino acid tyrosine in the peptides,...

Symbiotic bacteria protect hunting wasps from fungal infestation

...icrobes are often other microbes that produce very potent antibiotics. Thus, an effective and elegant way to counter the threat caused by bacteria and fungi is to establish a symbiotic relationship with innocuous antibiotic-producing bacteria that provide protection against the most dangerous pathogens. As ...

Gladstone investigators discover how resting T cells avoid HIV infection

...ng CD4 T cells are not. The team discovered that a potent antiviral factor called APOBEC3G (A3G) is the key....r. "The possibility of exploiting the natural and potent antiviral properties of A3G to control HIV infection is very exciting," says Greene. "We have learne...

Red delicious, Northern Spy apples have most antioxidants, chemists find

... Alzheimer’s disease. In rats, quercetin –?another potent antioxidant abundant in apples –?appears to protect brain cells against oxidative stress, a tissue–damaging process associated with Alzheimer’s and other neurodegenerative disorders. This study was published in the December 1, 2004, issue of the Jour...

NIAID begins clinical trial of West Nile virus vaccine

...ellular and antibody immunity offers a potentially potent defense against West Nile virus," says Barney Graham, M.D., Ph.D., chief of the VRC's Clinical Trials Core Laboratory. Adds Dr. Graham, "In our experience in clinical trials, DNA vaccines generally cause few side effects, making them a promising alte...

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

...compounds of this type. In addition to being more potent than naturally occurring sphingolipids, the researchers have also found that Enigmols can be administered orally and appear in often-difficult-to reach organs such as the prostate. "This is what suggested to us that Enigmols should be tested against ...

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