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Tag: "potent" at biology news

Soils offer new hope as carbon sink

...ous oxide (a greenhouse gas more than 300 times as potent as carbon dioxide). NSW DPI environmental scientist Steve Kimber said an added benefit for both the farmer who applies agrichar and the environment is that the carbon in agrichar remains locked up in the soil for many years longer than, for exampl...

Newly discovered antibody may be body's natural defense against Alzheimer's

...latively benign, oligomers have been implicated as potent toxins responsible for Alzheimer's-linked memory loss and brain cell death. This has led many scientists to speculate that oligomers may be the main culprit in Alzheimer's and therefore a prime target for a new generation of disease-modifying treatme...

Weizmann Institute scientists develop a general 'control switch' for protein activity

... serve as targets for new drugs. Beyond offering a potent tool that can be applied to any protein, the method has an important advantage compared with other techniques: It allows the total and precise control over the activity of an engineered protein. Such activity can be brought to a desired level or retu...

Investigating the measles virus as a tool to kill multiple myeloma

...administration of higher and potentially even more potent viral doses. The glioblastoma multiforme trial, which opened in the fall, is testing the safety of another strain of the measles virus for treatment, one that also enables biological monitoring of anti-tumor activity. Dr. Russell’s team also is l...

Researchers learn what sparks plant growth

...ant tissues. According to Chory, brassinolide is a potent growth hormone involved in the plant’s response to light. Such responses, which include adjusting plant growth to reach light or strengthening stems to support leaves, are central to plant survival. Brassinosteroid biosynthesis has become a criticall...

Bypassing eggs, flu vaccine grown in insect cells shows promise

...wing vaccine in eggs, a danger when working with a potent bird-flu strain. The technology would also help make it possible to boost the dose that patients receive, by increasing the nation’s capacity to churn out vaccine. That’s especially crucial in the fight against bird flu, as Treanor and other scien...

Hybrid molecule causes cancer cells to self-destruct

...oblem, scientists have tried to make butyrate more potent by modifying it or joining it to other compounds. Usually, the results have been disappointing because the molecular partner added to butyrate to improve delivery to the cancer cells often produced unsafe side effects. In some of the less successf...

Hotspots of mercury contamination identified in eastern North America

...wildlife health. The team focused on levels of the potent neurotoxin in yellow perch and common loons, but it also took into account contamination in other fish, birds, and mammals. In addition to these hotspots in New England, New York, and Nova Scotia, the researchers found nine "areas of concern" in thes...

3 proteins may play important role in nerve-cell repair

...ndant in the nerve cells, while GPR12 was the most potent at stimulating growth of the nerve extensions. The study showed that blocking GPR3 greatly slows the growth of the nerve extensions. The researchers reversed this effect by restoring either GPR3 or GPR12 in the cells. High levels of the three pro...

New protein inhibitor impedes growth of cancerous cells

...h they term BI 2536, that they demonstrate to be a potent inhibitor of Plk1, and show that BI 2536 can indeed effectively halt the growth of cancerous cells, both in cell culture and in an animal model for human tumor growth. BI 2536 caused growth arrest and cell death in cell lines derived from a variety o...

Destructive enzyme shows a benevolent side

...hese mRNAs carry the information for making highly potent proteins, proteins that cells must stop making suddenly. When that 'stop' command arrives, the pin is pulled and the enzyme destroys the mRNA, quickly halting production of that protein. This new study found, however, that under stress conditions,...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...th its negative regulator MDM2. This is based on a potent and selective small-molecule inhibitor of the p53–MDM2 interaction, the Nutlin-3a, originally discovered by Dr Lyubomir T Vassilev (Roche Research Center, Nutley, NJ., USA). Nutlin-3a has been suggested to be a potential treatment option for cancer...

OHSU lab finds meth receptor that could lead to therapy

... clear evidence that methamphetamine is a full and potent agonist of TAAR1. In other words, TAAR1 has the necessary features to be considered a real target of methamphetamine and amphetamine in rodents and probably humans, too." Grandy added that it's his hope that "these findings will eventually lead to...

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses

...ls ending with the production of interferon beta?a potent inhibitor of virus replication. Recent research has shown that hepatitis C generates a protein called NS3/4A that chops up MAVS, interfering with immune signaling and possibly providing the cover the virus needs to survive so long in the liver. Now, ...

Trojan horse strategy defeats drug-resistant bacteria

...medicine and microbiology at the UW. "The body has potent defense mechanisms to keep iron away from infecting organisms, and invaders must steal some if they are to survive." Iron is critical for the growth of bacteria and for their ability to form biofilms, slime-encased colonies of microbes that cause...

Inflammation may play role in metastasis of prostate cancer

...bly breast, cancer metastasis. "Maspin is a very potent inhibitor of metastasis; in a patient with metastasis, cells have found a way to turn off Maspin, which may depend on invasion of the tumor with RANK ligand-producing cells that activate IKKa," said Karin. Malignancies progress through stages. In ...

Researchers uncover protection mechanism of radiation-resistant bacterium

...ging the focus from DNA damage and repair toward a potent form of protein protection. These findings point to new avenues of exploration for radioprotection, which could eventually influence how individuals are treated for exposure to chronic or acute doses of radiation; could lead to ways to protect cancer...

Scientists unlock mystery of embryonic stem cell signaling pathway

... the cells to keep dividing and to remain as fully potent stem cells. “This way, you can essentially maintain the stem cell’s growth and potency for as long as you want,?Kahn says. The studies of IQ-1 and its effects reported in the newly published PNAS paper were performed at the University of Washington i...

Scientists uncover new target in cancer mutation puzzle

...ttle understanding of how Ras and p53 or any other potent gene mutations cooperate to cause malignant tumors," said Land, who is professor and chair of the Department of Biomedical Genetics and scientific director of the James P. Wilmot Cancer Center at the University of Rochester Medical Center. "But we ha...

Biodiesel won't drive down global warming

...herwise known as laughing gas, that is 200-300x as potent a greenhouse gas as CO2. The results of this analysis should have big implications for policymakers. The 2003 EU Biofuels Directive aims to increase the levels of biofuels to 5.75% of all transport fuels by 2010, up from roughly 2% currently. This...

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