Botox could help target resistant tumors for treatment
...dea of using Botox against cancer and explores the possibility of its use as an adjuvant, assisting the effective... without serious toxicity, the study indicates the possibility for human trials. In addition, dosages used in the mouse study were within the range used with human...Less is more, gene study shows
...d up with our unique traits, Zhang said. The first possibility is that we acquired completely new genes that other apes don't have. Another is that some of our genes have taken on different functions through mutation. It's also possible that we humans lost some genes along the way, and those losses provided op...Alternatives to the use of nitrate as a fertiliser
... farming. Research for sustainable farming The possibility of using animal ammonium or urea as nitrogenated sources from certain plants enables the study of these forms of nitrogen as an alternative to nitrates. Nevertheless, ammonium, despite being the most respectful with the environment, does not produce ...Rare Chinese frogs communicate by means of ultrasonic sound
...e frogs do not have external eardrums, raising the possibility of unusual hearing abilities. "Now we are getting a better understanding of why their ear drums are recessed," Feng said. "Thin eardrums are needed for detection of ultrasound. Recessed ears shorten the path between eardrums and the ear, enabling the...Macrophage signaling may affect hormone resistance in prostate tumors
...," Rose said. The UCSD research team explored the possibility that external signaling from macrophages in the prostate tumor microenvironment might affect hormone resistance.Using cell biology methods, they discovered a mechanistic explanation for at least one form of resistance to androgen antagonists. "It w...Component in soy products causes reproductive problems in laboratory mice
... said Newbold. "I don't think we can dismiss the possibility that these phytoestrogens are having an effect on the human population," said Dr. Jefferson. "They may not show their effects or be detected until later in life, but chances are they are having an effect." ...Therapeutic prospects beyond Vioxx
...ts are in mice, not people, they raise an exciting possibility which can be tested in humans," says senior author Garret FitzGerald, MD, Director of Penn's Institute for Translational Medicine and Therapeutics, Ever since the association of selective inhibitors of COX-2 ?Vioxx, Bextra, and Celebrex ?with an inc...For the first time: Longevity modulated without disrupting life-sustaining function
...ome of Dillin's earlier research had hinted at the possibility that "specificity" factors may control how and whether insulin and IGF-1 impact a target gene. Identifying those factors one by one would allow scientists to separate the different functions of insulin/IGF-1 signaling and to manipulate them individua...Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
... traumatic brain injury also raises the disturbing possibility that standard invasive procedures such as surgical biopsies or partial tumor resections may be inducing a proangiogenic response, or trigger, within the brain," cautions Dr. Fine. ...Most human-chimp differences due to gene regulation ?not genes
...s. "Together," they add, "these findings raise the possibility that the function and regulation of transcription factors have been substantially modified in the human lineage." This is a very efficient way to make big changes with very little effort, according to Gilad. By altering transcription factors, the en...Liquid crystals show promise in controlling embryonic stem cells
...ials and human embryonic stem cells, including the possibility of straining embryonic stem cells as they grow. "Stem cells tend to be smaller and have a slightly more compact shape than the differentiated cells," says chemical and biological engineer Sean Palecek. "Differentiated cells appear to be much more s...Molecular force field helps cancer cells defend against attack
...iversity, said the research raises "the compelling possibility of targeting FAK for a novel cancer therapy." "FAK plays a major role in the survival of tumor cells in their normal attached state, and, when over-expressed or hyperactivated, it opens a molecular gate that allows tumor cells to detach and metastas...Ancient fossil DNA found preserved in crystal
...ll, and the use of sodium hypochlorite reduces the possibility of modern contamination. The crystal aggregates act as a "privileged niche in fossil bone," protecting the DNA from hostile environments and leaving it relatively undamaged over time. The team's findings suggest that the DNA in these aggregates sho...Evolution mystery: Spider venom and bacteria share same toxin
...erium," she added. "A pattern like this raises the possibility of lateral gene transfer as a explanation." Lateral gene transfer refers to the movement of genes between the genomes of unrelated organisms. This contrasts with vertical transfer of genes from parent to offspring. Cordes and Binford found a common ...New weapon in battle against osteoporosis
...on and in this way slow down their bone loss." The possibility that this approach can work has been demonstrated by the experiments on mice without ovaries. The findings hold out hope for women with a CB2 defect, too. First, it is easy to identify whether a woman is carrying the relevant mutation, so the resul...p53, tumor suppression and aging
...young age due to increased expression of Mdm2. The possibility that inhibitors of Mdm2 could delay cancer in such people without causing detrimental side effects is bolstered by our demonstration that mice expressing 30-80% the normal level of Mdm2 develop fewer tumors than wild type mice, yet age normally." ...'Prosthetic' retinal cells let blind mice see light
... made a paradigm shift in the field and opened the possibility of genetically modifying the surviving retinal interneurons to function as a replacement light-sensing receptor," wrote John Flannery and Kenneth Greenberg in a preview of the paper in the same issue of Neuron. "This publication is clearly a signific...Hepatitis C therapy: Inhibiting newly discovered microDNA molecule
...s with its target 5' NCR, and opens an interesting possibility that other viral 5' NCRs are similarly targeted by different miRNAs. ...Plastic surgeons countdown first full facial transplantation
...ent Bruce Cunningham, MD. "What we thought of as a possibility ?reconstructing the entire face of someone with a severe facial disfigurement, in one surgery, from one complete facial skin flap taken from a donor ?is no longer just theory, but will become an actuality." "Through these particular studies we have ...First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
...ng between mitochondria and myofibrils opens a new possibility to search for drugs capable of increasing cardiac contractility," Veksler said. *Presentations: The paper, "Direct mechanical communication between mitochondria and nucleus in cardiac cells," was chosen to be part of the "Physiological Genomics of S...