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Tag: "pore" at biology news

Why we could all do with a siesta

...rd-seeking and addiction. "We have identified the pore in the membrane of orexin-producing cells that is responsible for the inhibiting effect of glucose. "This previously unknown mechanism is so sensitive it can detect minute changes in glucose levels ?the type that occurs between meals for example. "...

New mechanism explains glucose effect on wakefulness

...ogical role for the recently characterized [tandem pore potassium] channels and shed light on the long-elusive mechanism of glucose inhibition, thus providing new insights into cellular pathways regulating vigilance states and energy balance," wrote Burdakov and colleagues. "These results provide evidenc...

MIT's molecular sieve advances protein research

...entists. "No one has been able to measure the gel pore sizes accurately," said Jongyoon Han, the Karl Van... at MIT. "With our nanopore system, we control the pore size precisely, so we can control the sieving process of the protein molecules." That, in turn, mea...

NHGRI aims to make DNA sequencing faster, more cost effective

...age of single-strand DNA through a nanometer-scale pore is driven by an electric field revealing informati...e sequencing approaches involve either the protein pore alpha-hemolysin or artificial pores in inorganic materials. This team will use protein-engineering t...

New approach could lower antibiotic requirements by 50 times

...nisms that enable them to throw out antibiotics. A pore in the cell wall would obviously cancel the efflux effect,' Hagens explains. Pseudomonas bacteria cause pneumonia and are a common cause of hospital-acquired infections. Experiments in mice revealed that 75% of those infected with a lethal dose o...

Protein overexpression at heart of heart failure

...ac [Ca2+]i transients is calcium entry through the pore subunit of the voltage-dependent L-type channels (...nsgenic mouse which was crossbred with the channel pore overexpressing mouse when still nonfailing (“Adaptive phase?. In the nonfailing double transgenics, ...

Microbes start immune response by sneaking inside cells

...d, bacteria were able to enter the cells through a pore in the cell membrane, and stimulate the cryopyrin-initiated immune response without activating TLRs. The researchers discovered that a protein called pannexin-1 creates the pore, like a devious undersea diver drilling a hole in a ship hull. The te...

New mechanism for nutrient uptake discovered

... at the surface of the cell's outer membrane. Each pore is capable of transporting nutrients individually, so we were really surprised to find that the pores simply can't act without stimulation from their neighbors." In earlier research the Carnegie scientists, with colleagues, identified the genes re...

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