Sleep deprivation doubles risks of obesity in both children and adults
...ildren as young as 5 years." Professor Cappuccio points out that short sleep duration may lead to obesity through an increase of appetite via hormonal changes caused by the sleep deprivation. Lack of sleep produces Ghrelin which, among other effects, stimulates appetite and creates less leptin which, amon...Salk and Stanford teams join forces to reveal two paths of neurodegeneration
...lopmental pruning and injury from flies to mammals points to general mechanisms which are most likely also at work in the human nervous system. Both investigators believe that these and related studies can help in the development of therapies that preserve injured axons and restore proper connections. Othe...A protein complex that untangles DNA
...s compared to the function in repair. "Evidence points to that the Smc5/6 complex work in two different pathways, one needed for repair and the other for untangling. We now aim to study how this works on a molecular level. This will bring us one step closer to the general goal ?a summary of the many mech...Ready, set, mutate?and may the best microbe win
...vailable for a specific molecular response, and it points to the intriguing possibility of developing a system to predict the specific mutations that pathogens will use in order to become resistant to antibiotics." Rice's study involved the heat-loving bacteria G. stearothermophilus, which thrives at up to...New light microscope sharpens scientists' focus
...and Betzig showed together that the closely packed points light in a semiconductor could be individually isolated and studied. Combining these earlier studies, Betzig later proposed that molecular-level resolution might be achieved in cells by imaging just a few molecules at a time and identifying each one...'Sticky' mice lead to discovery of new cause of neurodegenerative disease
...tually triggers cell death. But this new mechanism points to errors in executing the genetic instructions, which are distinct from known causes of neurodegenerative diseases, such as Alzheimer's and Huntington's diseases. HHMI investigator Susan L. Ackerman and her colleagues reported their findings in a...NHGRI announces latest sequencing targets
... infectivity. Those genes will be logical starting points for developing more effective diagnostic, prevention and treatment approaches to fungal infections in both humans and animals. Also selected in the latest round is a project to sequence up to 50 strains of the yeast Saccharomyces cerevi...Virus has 'catastrophic' affect on red squirrels, research shows
...o target grey squirrel control at the narrow entry points and corridors to England's 16 designated red squir...e species. Small, targeted control at local entry points to refuge areas is an accepted management strategy and already works well in controlling populations...BGSU biologist trying to crack microscopic code
...es--antibodies--as well as certain antibiotics, he points out. While keeping potential dangers out, the outer membrane must also be porous enough to allow nutrients in, he continues. As an analogy, he cites a house with a yard and a chain-link fence that "keeps the dogs out of the roses but lets the butte...Scientists aim to thwart use of flu as bioweapon
...hat with computers, is the goal of the center. Wu points to the improved treatment of HIV as an area where such an approach has already yielded enormous benefit to patients. Once considered a death sentence, HIV infection is now more commonly viewed as a chronic infection thanks largely to improved treatme...High estrogen levels associated with dementia in older men
... in the middle and highest tertile had .24 and .28 points lower CASI scores, respectively, for each year increase in age. The researchers hypothesize that the estradiol association could be explained by increased aromatase activity in the brain which may be associated with a neurodegenerative process. It ...New potential drug target in tuberculosis
... their atomic structures, in hopes of finding weak points and new inhibitors." A protein called LipB is essential for the organism because it activates cellular machines that drive the bacterium's metabolism. Stefan Kaufmann's department at the MPIIB has specialised in the biology of M. tuberculosis infect...Attacking cancer's sweet tooth is effective strategy against tumors
...ely ignored. Few have attempted to attack specific points along the glycolytic pathway to gain a therapeutic effect. "LDHA could be one weak point that we could attack but maybe, if we understand exactly all the steps involved, we could devise alternative strategies to attack the same pathway," said Fantin...Major obesity gene is 'lost in the shuffle'
...ling them to thrive in the jungle canopy." Ishida points out that future studies of gibbons and other primates will enable scientists to examine the physiological effects of the ASIP deletion. "This will allow us to identify the specific metabolic roles of ASIP in vivo by comparing a species that has th...UC San Diego biologists solve plant growth hormone enigma
...ould not just be novelty items. For example, Zhao points out that seeds significantly increase the effort and waste involved in producing tomato sauce. "This study is a real tour de force," commented Martin Yanofsky, a professor of biology at UCSD, who was not one of the authors of the study. "People hav...Science finds new fix for UV-damaged skin in arthritis treatment
...iacinamide - which block melanin at two different points in the pigment producing process - are among the newest and most studied. "Pigmentation is an appearance issue that strikes an emotional chord for women, and even though we're constantly telling our patients about the importance of UV-protection, o...Predicting successful outcomes in living-donor liver transplants
...useful for LDLT recipients, while the second study points out that liver regeneration might not be complete for donors, even though the liver achieves its full size within four weeks of transplant. "Whether the about 10 percent loss of function compared to preoperative values will translate into clinically ...Inflammation and drugs to control this activity studied in a variety of tumors sites
...but we're on the road to finding out. "This again points to the fact that brain tumors are caused by a combination of several environmental, endogenous and genetic factors," he said. "They are not related to one specific cause, but rather, to several that are interplaying with one another to create tumors....Prenatal nicotine exposure reduces breathing response of newborns...
...s. Only the one mother had an infection. But Han points out that in this small study it was one in six of the mothers under 30 weeks and in the overall population could mean many more women with infections that bring on early labor or the need to induce labor to protect the baby from an infection during t...First link of oral bacteria and preterm birth found in human
...s. Only the one mother had an infection. But Han points out that in this small study it was one in six of the mothers under 30 weeks and in the overall population could mean many more women with infections that bring on early labor or the need to induce labor to protect the baby from an infection during t...