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Genomic Analysis Uncovers New Targets for HIV Vaccine

...st individuals in how they control HIV-1, but also point torward new mechanisms of control," said Goldstein...mune system is battling the virus, and this is the point in the infection's natural history that the researchers studied. The CHAVI investigators wanted to ...

Identified main genetic variants involved in response to HIV

... role in the control of viral infection. Results point to two gene variants related to the immune system. More precisely, these variations are in a genetic region responsible for the determination of immune response capacity against a number of infectious diseases, including AIDS. These variations are lo...

Agent slows aging in mice

...rmal diet. Scientists measured the difference at a point called median lifespan, when half the control mice had died of natural causes associated with aging. “This is the first time to my knowledge when an agent has been shown to extend median life span in three laboratories,” says Miller, professor of...

Simulations unravel outer membrane transport mechanism

...rane transporter. The yellow sphere represents the point on the TonB protein at which the force was applied. To view the results of the simulation, please go to: http://www.life.uiuc.edu/emad/TonB-BtuB/btub-2.5Ans.mpg Credit: Image courtesy of Emad Tajkhorshid To address these limitations, Tajkhorsh...

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

...untries with a greater ethnic mix.” The authors point out that the general increase in incidences of skin cancer, coupled with ageing populations, will place greater demands on dermatology and other related specialties over the coming years. “The number of people aged 60 and over is set to rise by mo...

Undergraduate research shows leaderless honeybee organizing

...so different. Evolutionarily, they got to the same point as humans – living in these highly organized societies that function with remarkable efficiency -- but they are organized so differently when you start digging into them,” Schneider said. “It’s interesting that these major differences can result in...

Could fungal collection hold the key to new life-saving drugs?

...ity will contain new compounds that can be used to point the way to new drugs for serious diseases.” CABI currently uses its fungal collection, along with the expertise of its scientists to offer a range of services to businesses, including fungal identification, sales, preservations, patenting, trainin...

Penn researchers link cell's protein recycling systems

...on different tracks, with similar purposes, but no point of intersection,” explains senior author J. Paul Taylor, MD, PhD, Assistant Professor of Neurology. “The new finding directly challenges this thinking by showing that one system can be induced to compensate for the other. Cells are able to shift prot...

Surprising origin of cell's internal highways

...r subset of these microscopic fibers. The findings point to a novel cellular mechanism that may guide cell ...entrosome has been considered the main origination point for microtubule "nucleation" in most cells. Until now. "I've seen that there are lots of microtu...

The mouflons of the Kerguelen archipelago

...plains Renaud Kaeuffer. The researchers stress the point that the genetic variety of the mouflons on the Kerguelen Islands is still less than what could be observed in a larger population. Very few researchers have carried out longitudinal studies on the evolution of genetic variety in a population. Th...

Gene therapy study shows safety and statistically significant improvement in Parkinson's disease

...reover, the absence of change at the earliest time point following treatment suggests that the improvement was not likely due to the surgical lesioning of the targeted brain region, as surgical approaches typically give rise to immediate, short-lasting benefit around the time of surgery, while prior studie...

Antarctic icebergs -- Hotspots of ocean life

...nique snapshot of these iceberg ecosystems at this point in history.” Using SDSC-developed technologies, Helly collected the data using the SIOExplorer-in-a-Box digital library system ( http://SIOExplorer.ucsd.edu ) and then stored the information in collections at SDSC for access and analysis by scien...

Modified mushrooms may yield human drugs

...ong a complexity of other factors, but researchers point out that the process of producing biopharmaceuticals is potentially faster and cheaper with mushrooms than conventional technologies. Unlike plants that have long growth cycles, "with mushrooms, we can use commercial technology to convert the veget...

Mule deer moms rescue other fawns

... their own. But while the study's findings seem to point to mule deer as superior mothers, the motivation for looking out for other fawns is likely based not on altruism but on simple survival, said Lingle. "Having a rigid and aggressive response to the simple sound of a fawn distress call may ensure ef...

Better insight into brain anatomical structures

...agent for anatomical brain imaging," Lee and Hyeon point out. "With this agent, we are able to get high-contrast views of the anatomical details of live mouse brain." The researchers hope that their new contrast agent will allow better research and diagnosis of brain diseases involving the CNS (central ner...

Arctic ice retreating more quickly than computer models project

... models indicate, both observations and the models point in the same direction: the Arctic is losing ice at an increasingly rapid pace and the impact of greenhouse gases is growing," says NCAR scientist Marika Holland, one of the study’s co-authors. The authors compared model simulations of past climate...

Resistant HIV quickly hides in infants' cells

...available treatments. However, it is important to point out that because PIs are the first-line drugs used to treat HIV infection in infants in the United States, PI-containing treatment was still effective in controlling the NNRTI-resistant virus in the infants in this study. As long as you do not use N...

How to look at dinosaur tracks

...f higher estimated hip length, and, as the authors point out, may also lead to slower speed estimates. ...

Climate change was the cause of Neanderthal extinction in the Iberian Peninsula

...rn Mediterranean paleoceanography. The conclusions point out that Neanderthal populations did suffer fluctuations related to climate changes before the first Homo Sapiens arrived in the Iberian Peninsula. Cold, arid and highly variable climate was the least favourable weather for Neanderthals and 24,000 ye...

Amphibians in losing race with environmental change

...t to go." In their analysis, the OSU scientists point out that evolution is not a precise or perfect process - it takes time, is constrained by historic changes and compromises, and does not always allow a species to adapt in a way that meets rapidly changing conditions. Through genetic variation and n...

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