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Tag: "players" at biology news

A new mechanism of regulating RNA degradation

... of ways to control gene expression, the trick for players in this game is to recognize them amidst the incredibly complex background of cellular machinery. Now, in a paper in the January 28th issue of Cell, Lynne E. Maquat, Ph.D., professor of Biochemistry and Biophysics at the University of Rochester Medi...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

... of ways to control gene expression, the trick for players in this game is to recognize them amidst the incredibly complex background of cellular machinery. Now, in a paper in the January 28th issue of Cell, Lynne E. Maquat, Ph.D., professor of Biochemistry and Biophysics at the University of Rochester Medi...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...etes is a complex metabolic disorder with numerous players such as high levels of blood glucose, cholesterol and other lipids. "The challenge is to figure out which factors are a primary cause of diabetes and which are a consequence, said Dr. Patti. "In our study, we needed to find out what was happening in ...

Study finds more than one-third of human genome regulated by RNA

...egated to the sidelines may be one of theprincipal players in regulating cellular mechanisms. "It's exciting to see how many genes are regulated by microRNAs. We nowknow that this type of gene control is much more widespread thanpreviously appreciated," says Whitehead Member and MIT professor ofbiology Davi...

NYU researchers simulate molecular biological clock

...egated to the sidelines may be one of theprincipal players in regulating cellular mechanisms. "It's exciting to see how many genes are regulated by microRNAs. We nowknow that this type of gene control is much more widespread thanpreviously appreciated," says Whitehead Member and MIT professor ofbiology Davi...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

...lab has helped clarify the role of some of the key players in this process, including a ubiquitous protein ca... at clathrin per se, and try and investigate other players in the endocytotic process," he said. ÒWe're going to ask questions such as, 'OK, if I tweak this mo...

Critical role in programmed cell death identified

...programmed cell death is so important and the more players we know that are involved, the more potential targets we have for therapeutics," Conradt said. During development, for example, many neurons are built, but after birth, more than half are eliminated in the central nervous system in mammals: "It's a c...

Opposing fat metabolism pathways triggered by a single gene

... for any animal, from nematodes to humans. Central players in the regulatory network are the nuclear hormone receptors (NHRs), which are transcription factors that turn on or off a set of target genes when bound by specific lipid molecules. In the premier open-access journal PLoS Biology, Keith Yamamoto and ...

Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis

...see considerable potential to make it possible for players of all scales in this industry to meet both long and short term objectives of cost savings, and the eventual development of oligonucleotide drugs that are affordable to patients,?stated Dr. Kenji Matsumoto, President of Kinovate Life Sciences, Inc. “...

Computational Method Speeds Mapping of Cell Signaling Networks

...hes where you need to know all of the intermediate players in a network, this system can detect indirect influences" between molecules. Pe'er suggests a similar technique could be used to study the differences between normal and abnormal cells. This application would be particularly useful for understanding...

Some Brain Cells 'Change Channels' To Fine-tune The Message

...ility has been recognized for a few years, the key players controlling it hadn't been identified. Now, by studying mice, the Hopkins team has identified two proteins, called PICK1 and NSF for short, that help replace channels that let charged calcium ions in with another kind of channel that keeps calcium ou...

Insects, viruses could hold key for better human teamwork in disasters

...t is the belief that civil engineers should be key players in disaster relief operations involving critical physical infrastructures -- a fourth group of "first-responders," along with firefighters, police and medical personnel. According to Pena-Mora: "The civil engineer's role -- particularly the engineers...

Some Brain Cells Change Channels

...ility has been recognized for a few years, the key players controlling it hadn't been identified. Now, by studying mice, the Hopkins team has identified two proteins, called PICK1 and NSF for short, that help replace channels that let charged calcium ions in with another kind of channel that keeps calcium ou...

Researchers develop promising new gene network analysis method

...nerated in the experiments revealed 1,191 possible players in the c-Myc gene network. A statistical team, led by Gastone Castellani, an associate research professor with the Institute for Brain and Neural Systems and a professor at the Università di Bologna, tested two methods to try to model this network. ...

Scientists discover stem cell origin of neck and shoulders

... commented, "Now that we have identified these key players in forming the neck and the shoulders we can start looking for the genes that are on in these stem cells and which are ultimately responsible for evolutionary changes over millions of years and are also behind a number of serious human illnesses. Thi...

Energy management in cells may hold key to cancer defense

...these two kinases, we think we have all nearly the players responsible for energy regulation within the cell, which should offer new opportunities in cancer treatment," said Hurley. "If we can stifle a cancer cell's ability to adapt to an energy deficit, it might lose its growth advantage." "You need to kn...

Simple explanation for complex pattern of feather development

...rom the simpler downy tufts by the addition of new players to the original activator-inhibitor pair. Prum is now following up on several clues in the search for these other molecular signals. ...

Oceans turning to acid from rise in CO2

...ankton and zooplankton, some of the most important players at the base of the planet's food chain. "We can predict the magnitude of the acidification based on the evidence that has been collected from the ocean's surface, the geological and historical record, ocean circulation models, and what's known about...

A 'dimmer switch' for genes

...domly structured regions believed to be only minor players in the protein world ?they become important in turning genes on and off, but in a way that resembles a dimmer switch rather than an on-off switch. Genes carry the code that produces proteins to carry out almost all functions in a living organism. Bu...

New study to explore cellular circuitry

...begin to identify the function of unknown cellular players based on their neighbors and associates," said Eric M. Phizicky, Ph.D., professor of Biochemistry and Biophysics at the medical center. "That puts us within reach of a completed diagram and the ability to re-wire cells in the treatment of disease."...

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