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Tag: "player" at biology news

A new mechanism of regulating RNA degradation

... first imaginated... As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

... first imaginated... As any dedicated video game player knows, the first requirement for using a weapon or tool is finding it. And it is no different for cell biologists and clinicians who want to take control of gene expression in cells to create therapies to treat disease. While cells have a variety of ...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

...ation of how cellular processesoccur."The cellular player responsible for the metabolic reprogramming is aprotein called Cth2. Thiele's team found that iron-deprived cellsoverproduce Cth2. This protein binds to the gene expression machineryof more than 80 different genes and targets these molecules, calledm...

Researchers identify target for cancer drugs

...new research is a protein called Akt, an important player in the regulation of cell division and survival. Abnormally high activation of Akt has long been implicated in a variety of cancers. If Akt travels to the cell membrane, it is switched on and promotes cell division, often contributing to tumor growth...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

...ng new technology to better understand how one key player -- a protein called clathrin -- helps regulate endocytosis like a well-oiled machine. It may also give us insights into the kinds of disease states that can happen when clathrin-regulated endocytosis goes wrong. The findings, already published onlin...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

..., a protein that has been shown to be an important player in keeping a cancer-causing gene called 'Ras' turn...companies to test compounds that block another key player in the pathway, a protein called farnesyltransferase. Blocking this protein inhibits Ras' ability to...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...s headed a study that identifies another molecular player influencing the initiation of colon cancers. This study will be published in the February 1 issue of the journal Genes and Development. An animal model with an inactivating mutation within the mouse equivalent of the APC gene displays very similar ...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...wn also as Lou Gehrig's disease, from the baseball player who succumbed to it, this harrowing disease has no cure and its pathogenesis is not very well understood. An estimated 5,000 Americans are diagnosed with ALS every year, and most of these cases are "sporadic", with no identifiable cause. About 5-10%...

'Smart drug' targets deadly brain cancer

...rget molecule. Knowing that this protein is a key player in the chain of events that determines drug activity could be useful in screening patients to help determine the best candidates for the drug. Says Dr. Galanis, "This could allow us to customize drug administration to the patients most likely to bene...

Brown-Harvard team solves mobile DNA's surgical sleight-of-hand

...s inserts its DNA into E. coli, λ-INT is the major player in the process, literally snipping the E. coli DNA strands before insertion and then sealing them up afterward. The research also suggests how three "helper" proteins ?think of them as nurses ?intricately fold the DNA strands during this surgery. Ma...

A protein in the eye may prevent immune response and protect eyes from disease

...ince the F4/80 protein was identified as a crucial player in the development of immune privilege, the Schepens' team postulated that the protein had an important role in immune regulation. In the current JEM study, the team investigated mice that did not produce F4/80. They found that the immune suppression...

The genetic origins of corn on the cob

...d the study. "The ramosa1 gene appears to be a key player in the domestication of corn, and we've shown that it acts by signaling cells to form short rather than long branches," says Martienssen, who was joined in the study by lead author Dr. Erik Vollbrecht, now at Iowa State University. Says Vollbrecht, ...

$6.5 Million Grant for Microarray Center at Yale School of Medicine

...d the study. "The ramosa1 gene appears to be a key player in the domestication of corn, and we've shown that it acts by signaling cells to form short rather than long branches," says Martienssen, who was joined in the study by lead author Dr. Erik Vollbrecht, now at Iowa State University. Says Vollbrecht, ...

Can't serve an ace? Could be muscle fatigue

...hed hamstrings and other injuries. "When a tennis player is serving, they don't watch where their shoulders are, they rely on the brain's knowledge of how much effort is required to maintain the best position, to get the ball where it needs to go. "However, if the limbs are fatigued the brain must activat...

Simple sea sponge helps scientists understand tissue rejection

...ch he has recently identified as another potential player in sponge tissue rejection reactions, and which is very easy to study in sponges. The human version of this molecule, which is different from the sponge version but similar in structure, is also believed to have important functions in cell-to-cell in...

India's smoking gun: Dino-killing eruptions

...se implicating the Chicxulub impact as the primary player in the Cretaceous-Tertiary (K-T) mass extinction. ...t Courtillot in 1986, the volcanism might be a key player in mass extinctions," said Chenet. "Research in India has shown the remnants of the impact - iridium...

Elusive salamanders have role in developing new sampling models

...Stewart herpetologist Dirk Stevenson is also a key player in the project and is responsible for monitoring the rare reptile and amphibian populations on base. Kara Ravenscroft, the project's technician, actually found the first salamander, which she trapped. In subsequent sampling she has extended the date...

UT Southwestern researchers discover master switch in cell death

...he interaction between the Mule enzyme and a major player in cell death, the protein Mcl-1. Dr. Wang said that while there are many possible routes a cell may take toward apoptosis, this interaction serves as one of the “master switches?controlling whether or not those other pathways are triggered. Normall...

UNC scientists discover new role for protein as fundamental inhibitor of cell movement

...n of PAK1 and potentially may be another important player in the regulation of this kinase," she added. The other activators of PAK1 include relatives of the notorious Ras family of tumor promoters, the GTPases Rac and Cdc42. CIB1 activation of PAK1, however, is different from these GTPases. "CIB1 activat...

Purdue researchers find key to rice blast fungus

...and Plant Pathology, found that an enzyme is a key player in coordinating the fungus' attack. The enzyme, called a pathogenicity mitogen-activated protein (MAP) kinase, flips the switch that starts the cellular communication necessary to launch the fungal invasion that kills rice plants or causes loss of gr...

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