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Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

...stem cells?depletion. MITF, they conclude, seemsto play a crucial role in maintaining the supply of stem cells withinthe hair follicle, and graying is the result of “incomplete maintenanceof melanocyte stem cells.?The research was supported by the National Institutes of Health, andNishimura received fundi...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

...stem cells?depletion. MITF, they conclude, seemsto play a crucial role in maintaining the supply of stem cells withinthe hair follicle, and graying is the result of “incomplete maintenanceof melanocyte stem cells.?The research was supported by the National Institutes of Health, andNishimura received fundi...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

...ain unknown, the tags in chromatin are believed to play a major role. Until now, however, it had not even ...surprise," Bernstein admits. HOX genes, as noted, play vital roles in embryo development. Understanding how they are regulated should help researchers dete...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...ssion, oractivity, of “target?genes. These factors play a pivotal role in braindevelopment by direction the formation of neurons and supporting cellscalled glia from uncommitted progenitor cells. Until now, braintranscription factors had not been systematically isolated and theirlocations within different...

New research questions basic tenet of neuron function

...smitter release. Spontaneous release is thought to play a role in the development of the neural circuitry in the brain and body, while activity-dependent release is responsible for functions such as learning and memory. ...

ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors

...colorful plumage. In addition, these pigments may play a valuable role in maintaining the health of parrots. McGraw cites an independent study on the parrot pigments that suggests that they can act as anti-oxidants to quench free radicals and potentially protect cells and tissues in the body from oxidati...

Transport System Smuggles Medicines Into Brain

...colorful plumage. In addition, these pigments may play a valuable role in maintaining the health of parrots. McGraw cites an independent study on the parrot pigments that suggests that they can act as anti-oxidants to quench free radicals and potentially protect cells and tissues in the body from oxidati...

Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra

... without foxes and speculated that nutrients might play a role. "He had these interesting ideas about foxes and birds and nutrient chains, and I thought we should do some studies to see how robust the idea is," Estes said. The team of researchers, accompanied by a small army of student assistants, condu...

Alcohol's effects on gene expression in the central nervous system

...tified individual genes and gene networks that may play an important role in determining the behavioral responses to alcohol as well as possibly influencing drinking behavior. "Thus far, genes that appear to be responsive to alcohol include genes involved in the intracellular signaling process (which can...

Scientists document complex genomic events leading to the birth of new genes

... one copy in humans. "Gene duplication is known to play a leading role in evolution for the creation of new genes," explained Francesca Ciccarelli, Ph.D., lead author on the study. The key to this, however, is that the duplicated copies of genes very quickly evolve functions that are significantly differe...

Zebrafish may hold key to understanding human nerve cell development

...sh as a model, we've demonstrated that glial cells play apreviously unidentified role in regulating the de...tory cue. It's possiblethat this signal could also play a role in the development of stemcells throughout the nervous system. Much more research is needed t...

Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined

...sh as a model, we've demonstrated that glial cells play apreviously unidentified role in regulating the de...tory cue. It's possiblethat this signal could also play a role in the development of stemcells throughout the nervous system. Much more research is needed t...

GenMAPP 2.0 released

...sh as a model, we've demonstrated that glial cells play apreviously unidentified role in regulating the de...tory cue. It's possiblethat this signal could also play a role in the development of stemcells throughout the nervous system. Much more research is needed t...

New research indicates a 'troubled' greenhouse is brewing

...ers to the stormy conditions shown to have been in play during a well-known greenhouse event some 55 million years ago during the late Paleocene epoch. Retallack explored the relationship between seasonality and rainfall in soils, then applied the same techniques to buried soils spanning the ancient green...

Tiny scaffolding allows stem cells to become working fat cells

...o become a huge reservoir for glucose as well, and play a role in insulins ability to effectively convert glucose into energy. "If we could learn how to control fat formation in the body, then we could keep people leaner, lowering their chances of becoming insulin-dependent, and lowering the likelihood t...

Bird Brains Show How Trial and Error May Contribute to Learning

...utshell, our paper suggests that the basal ganglia play a special role in generating motor variability," Brainard said. "It's been known for a long time that this circuit is important in learning. Our data supports the hypothesis that one of the things it could be doing is introducing variability." Other...

Scientists discover that host cell lipids facilitate bacterial movement

...lleagues decided to explore the roles these lipids play in Listeria infection. "We had expected to see PIP2 and PIP3 only at the very back of Listeria where new actin assembly was taking place," recalls Dr. Southwick. "To our surprise these lipids also localized to the front of the moving bacteria." The ...

UCSD team discovers specialized, rare heart stem cells in newborns

...rdiogenesis." "We think that these cells normally play an important role in the remodeling of the heart after birth, when the newborn heart no longer relies upon the mother's circulation and oxygenation," Chien said. "We believe the isl1+ progenitor cells are left over from fetal development so that they...

Implanted Devices Detect High-Risk Heart Failure Patients

... and mortality one year later. "This approach may play a significant role in targeting a subset of heart failure patients for whom we need to be more aggressive if we don't see early improvement in heart rate variability," Gilliam said. "We would expect that as their heart function improves after implant...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...fferent regions of the brain that are all known to play a role in responses to alcohol and other drugs of ...entify several genes regulated by alcohol that may play a role in determining genetic differences in behavioral responses to alcohol. "These findings help ...

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