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Tag: "plasma" at biology news

Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs

Transferrin, a plasma protein found in blood, can be fused with large, protein-based drugs such as granulocyte colony-stimulating factor (G-CSF) to create a new oral compound that is capable of surviving the journey through the gastrointestinal (GI) tract and then able to...

Basis for DNA ejection from single phage particles

... the envelope of these viruses fuses with the host plasma membrane so that the genome is delivered without directly contacting the membrane. Phage nucleic acid transport poses a fascinating biophysical problem: Transport is unidirectional and linear; it concerns a unique molecule the size of which may repr...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

... response to bacterial endotoxin, as well as lower plasma levels of NO2- and NO3- and less mortality than normal mice. The scientists also showed that endotoxin activates eNOS in macrophages and that this effect is an essential trigger for the induction of iNOS. "eNOS has until recently been thought to act...

Multi-purpose protein regulates new protein synthesis and immune cell development

...led B lymphocytes develop into antibody-generating plasma cells. Plasma cells secrete large amounts of prote...ne cells. Knowing that XBP1 was required to create plasma cells, Zhang designed a study to see if IRE1 was involved, also. Zhang studied mouse embryos that w...

50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel

...is active and essential outside the nucleus at the plasma membrane," said study author Steven Goldstein, M.D...t the SUMO-conjugating enzyme was plentiful at the plasma membrane, just inside the cell surface. They next showed that it added SUMO to a specific part of th...

HIV vaccine trial breaks ground for future research

... infection, and for those who were positive, HIV-1 plasma RNA load and CD4 cell counts were monitored on a regular basis for 24 months after the initial diagnosis. Of the 5,417 volunteers who were enrolled, 368 became infected during the study. The vaccine was found not to be effective in preventing HIV in...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...als for unchecked growth. "Ras needs to be at the plasma membrane in order to function," he said. "By preventing Icmt from adding a methyl group, we can effectively shut down Ras' ability to function, stopping it from sending signals for uncontrolled growth." Initial experiments showed that knocking out t...

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