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Tag: "plaques" at biology news

Brain inflammation may be friend, not foe, for Alzheimer's patients

...and helping get rid of clumps of material known as plaques that are a hallmark of the disease. While many ...eta stuck in overdrive had only about half as many plaques as mice without the over-active IL-1beta. Through extensive experiments, the team showed that the...

In mice, drug protects against diabetes and atherosclerosis

...s" that adhere to artery walls, creating dangerous plaques that eventually may rupture and trigger a heart at...ents, the drug treatment reduced the size of fatty plaques in the animals' aortas by more than 50 percent compared to control mice. To study the impact of t...

Study offers clues to 'Broken Heart Syndrome'

...ether the patient has clogged arteries or unstable plaques that are not visible on coronary angiography. These findings will help guide long-term treatment. "Because we don't yet know what causes this phenomenon, we don't know what the best long-term management should include," he said. "As we gather mor...

Cold sore virus might play role in Alzheimer's disease

...ociated with both the cellular tangles and amyloid plaques that are found in the brains of patients with the ...by Alzheimer's disease, before any of the hallmark plaques or tangles and certainly long before any behavioral changes are seen. Such inflammation often is a b...

Scientists find new genetic clue to cause of Alzheimer's disease

...d into amyloid beta protein fragments that make up plaques in the brain. The researchers began their search for genetic influences amid a group of proteins that transport APP within cells, looking for small changes, or "misspellings," in seven genes involved in moving APP within cells. To start, the scien...

New research shows that flu is a trigger of heart attacks

... in some patients, can destabilise atherosclerotic plaques [2] in coronary arteries and cause heart attacks. ...ome patients the quiescent, stable atherosclerotic plaques undergo sudden changes, mainly due to exaggerated inflammation, leading to rupture of these vulnerab...

Blocking immune cell action increases Alzheimer's-associated protein deposits

...ponse against amyloid-beta, the protein that forms plaques in the brains of patients with Alzheimer's disease, appears to protect the brain from damage in early stages of the devastating neurological disorder. A report from Massachusetts General Hospital (MGH) researchers finds that lack of a protein requir...

Light wine intake is associated with longer life expectancy in men

...mation, progression and rupture of atherosclerotic plaques ?the build-up of fatty tissue in the arteries that can result in stroke or heart attack. "Those people who already consume alcoholic beverages should do so lightly (1 to 2 glasses per day) and preferably drink wine," Streppel said. "The cardio-pro...

Signal protein shows promise for blocking tumor promoters in skin cells

...controlled cell growth with thick, scaly, hairless plaques on the skin. These plaques, or lesions, resembled precursors of cancer. Breeding experiments with the mice indicated that high Srcasm levels counteracted the effects of Fyn. The findings reveal that levels of Fyn and Srcasm work in a kind of see-...

PET imaging shows young smokers quick benefit of quitting

...m—the innermost layer of the artery—and over time, plaques can narrow coronary arteries, allowing less blood to flow to the heart muscle. Rupture of these plaques may result in a stroke, heart attack and death. It's generally known that the risk of death from...

Novel pathway regulates timing of brain cell development

...r's disease, and that erbB4 is abundant around the plaques found in Alzheimer's patients' brains. Taken together, the evidence suggests that presenilin's role in Alzheimer's may have to do, in part, with its effects on erbB4 activity--an effect that was previously unrecognized. ErbB4 signaling also regulates...

Enzyme shreds Alzheimer's protein

...ound that CatB tended to accumulate within amyloid plaques and that it acted to reduce Aß levels in neurons. And they found that introducing a pathological form of Aß, called Aß1-42, into neurons increased CatB in young and middle-aged mice with human APP, but not old mice. "Thus, upregulation of CatB may re...

A sweet solution for Alzheimer's disease?

...improved. Cognitive function was improved, amyloid plaques disappeared, inflammation declined, and the mice lived longer. The scientists found that scyllo-inositol conferred these benefits not only if the mice were treated when they were very young and disease-free, but also if they were treated after the ...

Experimental drug reverses key cognitive deficits, pathology in Alzheimer's

...d hippocampus--known to develop severe deposits of plaques and tangles in AD patients. Dysfunction in acetylc...thways had been knocked out, creating both amyloid plaques and neurofibrillary tangles. In their experiments, the researchers gave the knockout mice eight wee...

Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown

...d eventually can lead to the brain/mind-destroying plaques and tangles visible years later in the cortex of Alzheimer patients. The Apolipoprotein E (ApoE) genotype is the second most influential Alzheimer risk factor, after only advanced age. The study used MRI to assess myelin breakdown in 104 healthy in...

The urban evolution lab

...en known to be the primary component of the senile plaques in the brains of patients. The new discovery demon...ween amyloid protein and the development of senile plaques and loss of cells. Amyloid protein originates when it is cut by enzymes from a larger precursor prot...

Researchers discover a new genetic cause of Alzheimer's disease

...en known to be the primary component of the senile plaques in the brains of patients. The new discovery demon...ween amyloid protein and the development of senile plaques and loss of cells. Amyloid protein originates when it is cut by enzymes from a larger precursor prot...

DNA gene vaccine protects against harmful protein of Alzheimer's disease

... 42, and a 60 percent to 77.5 percent reduction of plaques in their brains. As controls, the researchers al... showed the large amounts of amyloid-beta 42 brain plaques normally seen in animals with these mutations. The gene injection showed superior results compared ...

Variant prion protein causes infection but no symptoms

... signal" from the abnormal prion protein * The plaques might be less toxic than the non-plaque form of pr...'s patients. "Previously, most researchers thought plaques were the toxic component of Alzheimer's that kills neurons, and many treatments focus on removing th...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...hat is necessary for the formation of the telltale plaques reverses the progression of the disease, and more ...gene that helps produce the characteristic amyloid plaques that are one of the hallmarks of Alzheimer's disease. "Within a month of treatment, mice that had a...

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