Molecular steps involved in the creation of gene-silencing microRNAs identified
...emarkably powerful molecules that appear to play a pivotal role in gene silencing, one of the body's main strategies for regulating its genome. A scant 22 nucleotides in length, miRNAs appear to work by binding to and somehow interfering with messenger RNA, itself responsible for translating genes into prote...Hopkins AIDS experts issue warning about global efforts to provide drug therapies
...bution of antiretroviral therapies. The first two pivotal events were advances to treat if not cure then-fatal diseases: the discovery of insulin for diabetes in 1922 and the mass distribution of the antibiotic penicillin in 1943. In the case of diabetes, insulin's availability turned a once-fatal disease ...Oceans more vulnerable to agricultural runoff than previously thought, study finds
...cultural runoff from the Mississippi River plays a pivotal role in creating this annual dead zone, which measured 8,500 square miles (22,000 square kilometers) in 2002-an area bigger than the state of Massachusetts. "In the Gulf of Mexico, there's the possibility that hypoxia could occur at a local scale, w...Computational Method Speeds Mapping of Cell Signaling Networks
...tiple components in thousands of cells at once was pivotal to the group’s success. Despite technical hurdles, the team believes similar approaches may be used in the future to study systems that involve multiple types of cells and their interactions, such as tissues and organs. NSF program manager Carter Ki...First 'atlas' of key brain genes could speed research on cancer, neurological diseases
...oractivity, of “target?genes. These factors play a pivotal role in braindevelopment by direction the formation of neurons and supporting cellscalled glia from uncommitted progenitor cells. Until now, braintranscription factors had not been systematically isolated and theirlocations within different parts of ...