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Tag: "phenotypic" at biology news

Scientists document complex genomic events leading to the birth of new genes

...ellular level, ultimately resulting in deleterious phenotypic consequences. If these duplicated genes acquire new functions, however, they may confer a selective advantage to an organism, leading to the rise of lineage-specific genes over evolutionary time. Bork's team identified a total of 22 genes with more ...

Optimizing cell therapy against tumors is a balancing ACT

...imics the human clinical situation. They find that phenotypic and functional qualities of T cells are associated with the ability of ACT to cause regression of large, established melanomas. Seemingly paradoxical, naïve and early effector T cells are more effective for tumor treatment than more differentiated T ...

Weapon performance determines mating success in the collared lizard

...nous mating systems, reproductive success reflects phenotypic variation. At the gross level, such phenotypic variation can include that of body size and weapon morphology, as well as of weapon function and per...

Phenotype is influenced by nature, nurture and noise

...nely described by cell biologists who record large phenotypic differences between supposedly identical cells in a single flask of growth medium. The mental picture most biologists have of a cell is of a smoothly running Swiss watch," said Hasty. "But our results and the findings of other theorists and computat...

Scientists fetch useful information from dog genome publications

...scribe the potential impact of these insertions on phenotypic diversity in dogs. "These SINEs are bimorphic, which means that at a given locus, some dogs have the SINE sequence while others do not," explains Kirkness. "This may have a profound impact on gene expression differences and disease determination in...

Dog genome sequenced

...scribe the potential impact of these insertions on phenotypic diversity in dogs. "These SINEs are bimorphic, which means that at a given locus, some dogs have the SINE sequence while others do not," explains Kirkness. "This may have a profound impact on gene expression differences and disease determination in...

Interactive 3-D atlas of mouse brain now available on web

... was created to establish a collection of baseline phenotypic data from commonly used inbred mice. The new brain atlas database consists of 3-D anatomical data from 10 adult male mice of the strain C57BL/6J, and contains data on 20 segmented structures, including variability of brain structures across the stra...

Relationship of brain and skull more than just packaging

...r study represents the first empirical evidence of phenotypic integration of brain and skull in 3D, although indirect evidence has been accumulating for years." The researchers are also interested in understanding how the skull and brain change jointly through evolution. Vertebrate evolution shows a trend towa...

Chimpanzee study reveals genome variation hotspots

... and their downstream implications for disease and phenotypic variation," Perry says. In the study, researchers looked at the structural genomic variation in DNA samples of 20 wild-born male chimpanzees. "We identified 355 copy number variants among the genomes of these 20 unrelated chimpanzees and found that...

A new kind of mutation could explain numerous phenotypic variations in various species

...dying sheep, could contribute significantly to the phenotypic variation observed in many species ?among which humans ?including the hereditary predisposition to various diseases. Researchers at ULg have thus produced a database available online that compiles all these mutations (the Patrocles database: http://...

Mutant mice show key autism traits

...ASD, although it is unreasonable to expect perfect phenotypic overlap of human ASD with any mouse model." Also, they wrote, "as appropriately pointed out by the authors, Pten deletion is restricted to postmitotic neurons in the CNS [central nervous system] in their model, and current evidence suggests that ASD...

New technology used to construct the first map of structural variation in the human genome

...ssion levels and may account for a large amount of phenotypic variation among individuals and ethnic populations, including differential responses to drugs and environmental stimuli. Mechanisms underlying the formation of CNVs also provide insight into evolutionary processes and human origins. Using microar...

Evolution of influenza A virus

...tensive surveillance, whole-genome sequencing, and phenotypic analysis....

Genomics throws species definition in question for microbes

...es arose," says Roberts. "Conflicts exist between phenotypic and phylogenetic information, the means for classi...nd microbial species do not always demonstrate the phenotypic or genetic cohesiveness expected of them. For these reasons and others it has become clear that the...

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