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Tag: "phenotype" at biology news

Bound for destruction: Ubiquitination protects against improper Notch signaling

...rease in nedd4 activity resulted inthe nicked wing phenotype characteristic of Notch loss of function andin reductions of the total amount of the Notch intracellular domain inthe cytoplasm of treated cells. Taken together, these results suggestedthat Nedd4 works as an antagonist of Notch signaling at an early ...

Researchers trace evolution to relatively simple genetic changes

...l syndrome. Instead, they cause evolution of a new phenotype in natural populations." The research with the wild fish also shows that the same gene is used whenever the low armor trait evolves. "We used sequencing studies to compare the molecular basis of this trait across the northern hemisphere," said Kings...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...l syndrome. Instead, they cause evolution of a new phenotype in natural populations." The research with the wild fish also shows that the same gene is used whenever the low armor trait evolves. "We used sequencing studies to compare the molecular basis of this trait across the northern hemisphere," said Kings...

Wisconsin researchers identify sleep gene

...told us that genetic forces push hard against this phenotype to make it ineffective," Cirelli says. "Being a short sleeper is probably not a good thing. We know that the mns mutation affects mortality, but we're not sure how." In earlier studies, Tononi's team discovered that fruit flies do, in fact, sleep. ...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

...n, the findings revealed a previously unrecognized phenotype characterized by discordant resistance to two widely used and mechanistically distinct antileukemic agents and provided new information about the cellular mechanisms involved in disparate response to these drugs. Specific genetic signatures related ...

Cellular Defects in Premature Aging Disease are Reversible

...t. "So demonstrating that we can rescue the normal phenotype without cell division means this procedure could be effective in all tissues." Misteli and his group will also look more closely at healthy cells to determine how similar progeria is to the normal aging process. For more information about progeria, ...

Gene keeps neural cells on correct developmental path

...t also allows the full elaboration of the neuronal phenotype from the precursor cell." Led by HHMI associate Nurit Ballas, a postdoctoral fellow in Mandel's lab, the study may advance stem cell research aimed at understanding repairing spinal cord injuries or replacing malfunctioning brain cells in neurodegen...

Microarrays as phenotype

...ay data. This means the microarray provides a good phenotype that is quantitative. We can prove that gene A comes before gene B and give mathematical support for these findings." "This is a proof of principle that we set out to do ?assessing the function of unknown genes is feasible," said Shaulsky. "It can b...

Random gene expression may drive HIV into hiding

...type of "noise" in gene expression could influence phenotype in infected mammalian cells, Weinberger said. "I thought it was a cool idea," he added, but "at the time, there wasn't a lot of data to support it. It was pretty far out there." Weinberger, Arkin, and their colleagues created a model HIV-1 vector--...

Scripps research scientists identify infertility molecule

...ptor knock-out mice for LPA3 produced a surprising phenotype -- fertility problems. Analyses revealed that the spacing of the embryos in the womb was altered, and the number of implanted embryos was reduced (mice have litters of pups, typically giving birth to eight or so offspring with each pregnancy). Also, ...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

... subsequently used in these studies retained their phenotype after being cultured, the researchers routinely tested whether their characteristic potential to differentiate into fat and bone cells was preserved. The researchers conceded that it "is surprising that the very transient presence of MSC in the inju...

miRNAs and musculature

...e, transcriptional regulation and loss-of-function phenotype of Drosophila mir-1 (Dmir-1). Mir-1 is an evolutionarily conserved miRNA, whose expression in mouse and humans is limited to heart and skeletal muscle. Strikingly, their study shows that, in Drosophila embryos, mir-1 expression is not required for m...

Phenotype is influenced by nature, nurture and noise

...vel of a fly, cat, or human." Changes in a cell's phenotype may be triggered by environmental factors, by programmed genetic instructions, or more subtly by built-in delays in biochemical pathways that generate oscillations, sometimes in 24-hour circadian periods. Hasty, graduate students Dmitri Bratsun and D...

Genetic and environmental influences on alcohol consumption among rhesus monkeys

...re is always the problem of precise measurement of phenotype and controlling for environmental variation in human studies ?which is not as great an issue in animal studies." ...

It's all in the genes

...n, Whitham and fellow researchers discuss how this phenotype is heritable on an ecosystem level. That is, the progeny of a tree are likely to support the same communities of organisms and ecosystem processes that their parents supported. It's a premise with far-reaching implications. Consider, for example, c...

Researcher gives hard thoughts on soft inheritance

...hat you're getting fed in the womb influences your phenotype ?physical and physiological attributes." Another study showed that early grooming and nurturing of rat pups by rat moms affects methylation of a glucocorticoid receptor gene in the hippocampus in the brain. If the pups get lots of nurturin...

Researchers attack tumor cells by exploiting dependency on sugar metabolism

...to lactate. Scientists believe that the glycolytic phenotype enables rapidly proliferating tumor cells to survi...umor survival and the interplay between glycolytic phenotype and mitochondrial metabolism. The researchers used a sophisticated genetic technique to reduce level...

Zinc plays important role in brain circuitry

...c pathway leads to a significant alteration in the phenotype of the animal." The three scientists added that the finding "puts a nice dent in the zinc armor, which held firm for more than 50 years." ...

Biologists call for better choice of model organisms in 'evo-devo'

...an be helpful in estimating how much an organism’s phenotype has changed." Dr Wills added: "Establishing criteria for choosing model organisms is important in this field, especially given the pressure on available funding sources. "We encourage evo-devo workers to communicate with funding agents so that...

Scientists identify a candidate gene for osteoporosis

...ating BMD, Mohan's team characterized the skeletal phenotype of mice with and without the DARC gene. The DARC -knockout mice exhibited increased BMD and lower bone resorption compared to mice with the DARC gene, supporting the predicted role of DARC in hastening bone resorption. They also showed that a...

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