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Tag: "phase" at biology news

Image of myosin-actin interaction revealed in cover story of Molecular Cell

...rotein on its actin track through the weak binding phase of the processive movement. The detailed molecular knowledge of how myosin interacts through the hydrolysis cycle with actin provides an exciting new research template onto which scientists can design new sets of experiments to further refine the my...

A resetting signal keeps circadian rhythm on track in Drosophila fruit flies

...rcher Dan Stoleru. "In this fashion, we introduced phase differences between them. It turned out that no matter the manipulation, the morning cells set the pace of the entire system, so that the rhythm always stayed on track." The study showed that the morning clock resets the evening clock every day, wit...

Study shows combination of immune substances to be safe

...on and his colleagues are conducting a multicenter phase II clinical trial of the two drugs in people with melanoma. Phase-II trials are the first step in determining the effectiveness of new therapy against a specific disease. "We believe that use of the two drugs together will give us more bang for t...

Researchers develop new method to help find deadly malaria parasite's Achilles heel

... group analyzed only the proteins expressed in the phase that infects human red blood cells, an infection that leads to fever, shaking chills, headache, muscle aches, and other symptoms. Ideker said critics may fault his study because only a subset of the Plasmodium's proteins is expressed in the erythrocy...

Travelers can avoid jet lag by resetting their body clocks

...s treatment can also help those with delayed sleep phase syndrome (DSPS), a persistent condition that resul...on of bright light and melatonin produces a larger phase advance than bright light alone," said Senior Author Charmane Eastman, Ph.D., Director of the Biolog...

Cellular scale drug delivery from the inside out

...happens and what specific changes take place. This phase of Lin's research ties into a larger plant metabolomics project at Ames Laboratory. ...

Hormonal male contraception reversible after few months for all men

...tive purposes, can be achieved. Currently, a large phase III study with an androgen treatment and a large, multicentre phase II study of androgen-progestagen combinations are being completed in China and Europe, respectively....

Gene needed for butterfly transformation also key for insects like grasshoppers

...ph simply repeats the appearance from its previous phase but continues to show normal growth, Erezyilmaz said. The organism eventually becomes an adult, but adult structures such as the wings are severely undersized. "Broad is not required to transform into the adult, but it is needed to move through the ...

Male rivalry increases when females at most fertile, say researchers

...refer their voices and odour. During this fertile phase women are more likely to have an affair with a masculine-looking man, as their features are linked to high testosterone levels, demonstrating good genetic qualities that can be passed on to offspring. New research at the University has found that m...

Hooked on fishing, and we're heading for the bottom, says scientist

...ournals, including Science and Nature. "We're in a phase where increasing fishing effort produces less catch." While global catches peaked in the late 1980s, the peak occurred earlier in those parts of the world where industrial fishing developed first. Thus, peak fish occurred in the mid-1970s in the Nor...

Scientists design potent anthrax toxin inhibitor

...tioned well in test-tube experiments. In the next phase of their research, Drs. Kane and Mogridge and their colleagues plan to test the action of their inhibitor in animals after infecting them with B. anthracis and allowing the disease process to begin. They also will evaluate the inhibitor with and with...

University of Utah to help build bionic arm

... How the Funding Will Work The initial two-year phase of the University of Utah's work will bring in up to $4.8 million. The second two-year phase could bring the total to $10.3 million, contingent on a successful first phase. Subcontractors shari...

Both alcoholism and chronic smoking can damage the brain's prefrontal cortex

... How the Funding Will Work The initial two-year phase of the University of Utah's work will bring in up to $4.8 million. The second two-year phase could bring the total to $10.3 million, contingent on a successful first phase. Subcontractors shari...

Waking a sleeping virus

.... The problem is that they only interrupt the late phase of the viral cycle. Since ZEBRA is essential to the first steps, waking the virus, blocking it would be much better." To identify weak points of ZEBRA as potential drug targets Morand and Carlo Petosa from Müller's group created a high-resolution ma...

Multi-million pound UK Biobank underway

...eing sent invitations to take part in the start-up phase of UK Biobank ?a revolutionary research undertakin...th-related records. The objective of the initial phase of recruitment is to make sure all of the planned procedures go smoothly before the study gets under...

Removing DNA repair gene causes metabolic syndrome

...reased levels of NEIL1 during the synthesis or "S" phase of the cell division cycle, during which DNA is replicated before the cell actually divides, NEIL1 is important to replication-associated DNA repair. In addition, NEIL1 has been shown to be localized in both the cell's nucleus and its power plant, th...

New analysis shows three human migrations out of Africa

...ghout Eurasia. "By the time you're done with this phase you can be 99 percent confident that there was recurrent genetic interchange between African and Eurasian populations," he said. "So the idea of pure, distinct races in humans does not exist. We humans don't have a tree relationship, rather a trell...

Computer simulation hints at new HIV drug target

...phy studies." These new inhibitors are moving into phase III human trials, he said. For his first round of simulations, Perryman chose a rare double-mutant protease enzyme with two mutations in the 99 amino acids that make up each half of the enzyme. One of those mutations, V82F, is common, and it can eme...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...phy studies." These new inhibitors are moving into phase III human trials, he said. For his first round of simulations, Perryman chose a rare double-mutant protease enzyme with two mutations in the 99 amino acids that make up each half of the enzyme. One of those mutations, V82F, is common, and it can eme...

Face perception is modulated by sexual orientation

...thought to act in reward circuitry may represent a phase in visual processing during which sexual orientation modulates how we perceive individual faces. The findings are reported by Felicitas Kranz and Alumit Ishai of the University of Zurich. Of all the visual skills possessed by humans, face recogniti...

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