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Tag: "phage" at biology news

Basis for DNA ejection from single phage particles

... tail structure that ensures the attachment of the phage to the host bacteria. A common feature of phages i... pressure built during packaging of the DNA in the phage capsid was responsible for DNA ejection. This pressure results from the condensation of the DNA duri...

Scientists find viruses can't stick to sea bugs in the dark

...f there is not sufficient light, the spread of the phage might be decreased, which could undermine the efficiency of phage treatment." Ying Jia hopes that the research will lead to a better understanding of the relationshi...

Anthrax test, developed by army and CDC, receives FDA approval

...ntion (CDC) in the mid-1950s. The modified gamma phage method is the first diagnostic test to gain FDA ap...f methods used to identify B. anthracis. The gamma phage is a virus capable of entering bacterial cells and causing cell destruction, or lysis--and it is spe...

'Mad cow' proteins successfully detected in blood

...ntion (CDC) in the mid-1950s. The modified gamma phage method is the first diagnostic test to gain FDA ap...f methods used to identify B. anthracis. The gamma phage is a virus capable of entering bacterial cells and causing cell destruction, or lysis--and it is spe...

Harmless virus may hold key to more effective HIV drug discovery

New phage display technique successful in identifying compou...and bind to other proteins, using a process called phage display. In this study, Weiss and Olszewski first created one such library by attaching the Nef prot...

UCSD discovery may provide novel method to generate medically useful proteins

...phage. However, the genetic mechanism used by the phage to generate this diversity is completely different...industry." The function of the massively variable phage protein is to tether the phage to the bacteria they infect. The phage "predator" protein fits into ...

New hybrid virus provides targeted molecular imaging of cancer

...hows how particles of the hybrid virus, called AAV phage or AAVP, can serve as a vehicle for targeted delivery of genes to experimental tumors in mice and to the tumors' blood vessel supply, providing a strategy for finding tumors and genetically marking them for imaging on a clinic-ready body scanner. Th...

Unraveling the viral mechanism

...ail" structures gives clues about how the virus or phage and cell interact. Then as Chiu and Jiang used the computer visualization tool to strip away the surface shell entirely, they saw the concentric coil of DNA underneath. They also identified a protein "hub" through which DNA enters and exits the viru...

Pitt phage hunter takes on tuberculosis

...e coatings. Furthermore, this occurred because the phage had disrupted a M. smegmatis gene called groEL1-which has a nearly identical counterpart in M. tuberculosis. The NIH grant will allow Hatfull and Jacobs to explore whether the Bomber also affects the groEL1 gene in the TB-causing germ. If so, it c...

Different strategies underlie the ecology of microbial invasions

...f the invading bacteria can be killed by their own phage parasites, upon their death they release a burst o...cing more parasites. Amplification therefore makes phage carriers able to successfully compete with phage-susceptible bacteria even faster when the carriers ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

... tissue environment surrounding the tumors. This phage displayed library ?called so after the bacteriophage viruses used to capture protein fragments ?was then isolated and tested. With the library, Dr. Diaz and his colleagues could select peptides that bind to tumors that are affected by a combinatio...

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