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Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

Nano-sized particles embedded with bright, light-emitting molecules have enabled researchers to visualize a tumor more than one centimeter below the skin surface using only infrared light. A team of chemists, bioengineers and medical researchers based at the University of Pennsylvania and the University of Minnesota has lodged fluorescent materials called porphyrins within the surface of a polyme...

Disease progression model of pancreatic cancer developed by Penn researchers

Building on previous work, researchers at the University of Pennsylvania School of Medicine have developed an animal model of pancreatic cancer that closely mimics disease progression in humans. From this, they hope to develop new treatments for this deadly disease. Advanced pancreatic cancer is among the most lethal of cancers, with a one-year survival rate after chemotherapy of only 17 to 28 pe...

Penn Researchers Use Robotic Surgery

For patients with cancer of the mouth and throat, surgery is a frequent course of treatment, often leading to speech and swallowing dysfunction and external scarring. Researchers from the University of Pennsylvania School of Medicine's Department of Otorhinolaryngology/Head and Neck Surgery, have completed two studies ?the most comprehensive and largest to date ?that demonstrate the effective use...

Penn study finds direct role for glial cells in brain cross-talk

Findings may help elucidate mechanisms of wake-sleep transitions and epileptic seizures .. . "This finding may cause neuroscientists to radically alter their view of the...

Penn Surgeons Use Completely Robotic Surgery to Successfully Treat Prostate Cancer

Prostate cancer is the second leading cause of death among American men. It is estimated that one in six males will develop the disease during his lifetime. However, promising new treatment options have been developed to help combat this threatening disease. . One of the most innovative of these treatments is robotic-assisted laparoscopic prostatectomy (removal of the prostate). Th...

Penn researchers study the use of ultrasound for treatment of cancer

For the first time, ultrasound is being used in animal models ?to treat cancer by disrupting tumor blood vessels. Researchers at the University of Pennsylvania School of Medicine completed a study in mice in which they used ultrasound both to see a tumor's blood perfusion and then to treat it with a continuous wave of low-level ultrasound. After three minutes of treatment at an intensity similar...

Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease

Liver transplants cured the metabolic symptoms of 11 patients with a rare but devastating genetic condition known as Maple Syrup Urine Disease (MSUD), according to a study by researchers from Children's Hospital of Pittsburgh and the Clinic for Special Children. . .. MSUD is a metabolic disease w...

Gatekeeping: Penn researchers find new way to open ion channels in cell membranes

Using an enzyme found in the venom of the brown recluse spider, researchers at the University of Pennsylvania School of Medicine have discovered a new way to open molecular pores, called ion channels, in the membrane of cells. The research team ?Zhe Lu, MD, PhD; Yajamana Ramu, PhD; and Yanping Xu, MD, PhD of the Department of Physiology at Penn ?screened venoms from over 100 poisonous invertebrat...

An AIDS-related virus tricks cells to become tumors, new Penn study finds

Researchers at the University of Pennsylvania School of Medicine have discovered how the Kaposi's sarcoma-associated herpesvirus (KSHV) subverts a normal cell process in order to promote tumor growth. The finding, published in the most recent issue of PLoS Pathogens, offers new potential strategies for treating Kaposi's sarcoma and other cancers associated with viruses. . KSHV is an opportunistic...

Good times ahead for dinosaur hunters, according to U of Penn scientist's dinosaur census

The golden age of dinosaur discovery is yet upon us, according to Peter Dodson at the University of Pennsylvania. In a forthcoming issue of the Proceedings of the National Academy of Sciences, Dodson revises his groundbreaking 1990 census on the diversity of discoverable dinosaurs upward by 50%, offering a brighter outlook about the number of dinosaurs waiting to be found. His findings also add...

Penn researcher shows that DNA gets kinky easily at the nanoscale

Scientists have answered a long-standing molecular stumper regarding DNA: How can parts of such a rigid molecule bend and coil without requiring large amounts of force? According to a team of researchers from the United States and the Netherlands, led by a physicist from the University of Pennsylvania, DNA is much more flexible than previously believed when examined over extremely small lengths....

Penn researchers replace organ in adult mice using 'single-parent' stem cells

Researchers at the University of Pennsylvania School of Veterinary Medicine have derived uniparental embryonic stem cells - created from a single donor's eggs or two sperm - and, for the first time, successfully used them to repopulate a damaged organ with healthy cells in adult mice. Their findings demonstrate that single-parent stem cells can proliferate normally in an adult organ and could p...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

Researchers at the University of Pennsylvania School of Medicine have discovered that an enzyme produced by lung-infecting bacteria further shuts down a protein that is defective in cystic fibrosis patients. The disruption to this protein that conveys ions from lung cells to airways causes thick mucus to buildup inside the lung. The finding suggests a new therapeutic target for treating lung infe...

Penn study on olfactory nerve cells shows why we smell better when we sniff

Unlike most of our sensory systems that detect only one type of stimuli, our sense of smell works double duty, detecting both chemical and mechanical stimuli to improve how we smell, according to University of Pennsylvania School of Medicine researchers in the March issue of Nature Neuroscience. . .. "The driving force for such sync...

Penn researchers show how nanocylinders deliver medicine better than nanospheres

Researchers at the University of Pennsylvania School of Medicine & School of Engineering and Applied Science have discovered a better way to deliver drugs to tumors. By using a cylindrical-shaped carrier they were able sustain delivery of the anticancer drug paclitaxel to an animal model of lung cancer ten times longer than that delivered on spherical-shaped carriers. These findings have impl...

Penn researchers link cell's protein recycling systems

. The cell has two internal pathways for breaking down proteins. The ubiquitin-proteasome...
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