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Tag: "pediatric" at biology news

Inheriting a tendency to brain infection

...ce supported that idea. The survey, conducted with pediatric neurologist Marc Tardieu of the Kremlin-Bicêtre hospital in Paris and genetic epidemiologist Laurent Abel of the Necker Medical School, revealed that a significant proportion of patients with herpes simplex encephalitis had parents who were blood rel...

Scientists use gene signatures to match cancer and other diseases with potentially effective drugs

...ced prostate cancer. Scott Armstrong, MD, PhD, a pediatric oncologist at Dana-Farber and Children's Hospital Boston, is senior author on a paper in Cancer Cell that describes how the method successfully identified a drug that can overcome therapy-resistant cases of acute lymphoblastic leukemia (ALL) in child...

Large-scale genomics project will hunt genes behind common childhood diseases

... one of the world's largest and most comprehensive pediatric networks, we have a sizable base of patients and f...lood samples. Children's Hospital will be the only pediatric hospital to have this technology entirely at its disposal." The Center plans to analyze blood sampl...

Scientists tie several cancers to common 'oncogene engine'

...tumors together," said David E. Fisher, MD, PhD, a pediatric oncologist at Dana-Farber and Children's Hospital ...lear cell sarcoma, alveolar soft part sarcoma, and pediatric renal carcinoma ?are often lethal if surgery cannot completely remove them. Dana-Farber researchers...

Speeding the search for elusive chromosomal errors

A pediatric research team has used commercially available gene chips to scrutinize all of a patient's chromosomes to identify small defects that cause genetic diseases. Because currently used genetic tests usually cannot detect these abnormalities, the new resea...

Autistic brain has fewer neurons for processing emotion

...der," says Emanuel DiCicco-Bloom, MD, professor of pediatric neurology at the University of Medicine and Dentistry of New Jersey. Authors Cynthia Schumann, PhD, of the University of California, San Diego, and David Amaral, PhD, director of the M.I.N.D. Institute at the University of California, Davis, counte...

UF scientists test improved gene therapy method for hereditary heart conditions

... the heart muscle and it was inefficient," said UF pediatric cardiologist Barry J. Byrne, M.D., Ph.D., the paper's senior author and director of the Powell Gene Therapy Center. "The difference here is that we can deliver a much lower dose of the vector into a vein like any other drug, and the corrective gene c...

New vaccine for condition that kills 500,000 children a year

... account for 2 million hospital visits and 500,000 pediatric deaths each year worldwide. In one of the largest...ited States annually, or about five percent of all pediatric admissions. It also results in 250,000 visits each year to U.S. emergency rooms. In the developing ...

UCLA paper examines how one disease may prevent another

...or his historical review from cases he saw while a pediatric resident at Babies Hospital in New York City. One case was a kidney disease patient with nephrosis who was unresponsive to medications but went into remission after contracting measles. The other, a cystic fibrosis (CF) patient who needed to be admit...

How can we protect patients with weakened immune systems from influenza?

...delphia and the University of Pennsylvania, led by pediatric immunologist Kathleen Sullivan, M.D., Ph.D., chief of Allergy and Immunology at Children's Hospital. "Our research focuses on the basic question of who benefits most from influenza vaccine," said Dr. Sullivan. "This question becomes paramount if inf...

Research details how a virus hijacks cell signals to cause infection

... infect cells," said Jeffrey M. Bergelson, M.D., a pediatric infectious diseases specialist at The Children's Hospital of Philadelphia. "We found new steps in the virus life cycle." Dr. Bergelson's study, co-authored with Carolyn B. Coyne, Ph.D., also of Children's Hospital, appears in the Jan. 13 issue of th...

Technique makes it easier to see mouse embryo in all its glory

...s called alveolar rhabdomyosarcomas. Dr. Keller, a pediatric oncologist, moved to the CCRI from the University of Utah in 2005, and continues his collaborations with engineers and computer scientists at Utah's Scientific Computing and Imaging Institute. Dr. Keller routinely works with mouse embryos in trying ...

Duke to test bird flu vaccine dosing

...alter said. Aluminum hydroxide is commonly used in pediatric and adult vaccines, including those for whooping cough, hepatitis A and hepatitis B. As with current flu vaccines given yearly in the U.S., the H5N1 vaccine causes the body's immune system to make antibodies to fight infection. In previous studies w...

Ancient DNA helps UF researchers unearth potential hemophilia therapy

...tics, and Cathryn Mah, a UF assistant professor of pediatric cellular and molecular therapy, used the transposon to inject the gene into endothelial cells, which line blood vessels and other parts of the body. This was unique, Fletcher said, because the liver is generally considered the body's powerhouse for p...

Infant transplant patients resist infections that kill adult AIDS patients

...B cells and antibody production in the outcomes of pediatric heart transplants. "We're very excited about this opportunity to expand the current understanding of the human immune system -- and hopefully, in the process, discover new treatments for debilitating diseases," says Dr. Platt. ...

Clinical trial to test stem cell approach for children with brain injury

...id James Baumgartner, M.D., associate professor of pediatric neurosurgery and co-principal investigator on the ...llment. After initial treatment and evaluation, a pediatric surgeon will approach the injured child's parents to explain the trial and request permission to enr...

Double trouble: Cells with duplicate genomes can trigger tumors

...for generating a tumor," says David Pellman, MD, a pediatric oncologist at Dana-Farber and at Children's Hospital Boston. He is the senior author on a report in the Oct. 13 issue of Nature. Takeshi Fujiwara, PhD, and Madhavi Bandi of Dana-Farber, are the paper's co-first authors. The research was performed in...

Reducing antibiotic use lowers rates of drug-resistant bacteria

.... The study found that reducing antibiotic use for pediatric respiratory tract infections resulted in lower rates of carriage of drug-resistant bacteria. Drug-resistant bacteria, commonly called "superbugs," are fast becoming a problem due to overuse and inappropriate prescribing of antibiotics. Streptococcu...

Customized gene chip provides rapid detection of genetic changes in children's cancer

...flexibility, said co-author John M. Maris, M.D., a pediatric oncologist at The Children's Hospital of Philadelphia. "As future research identifies other genes active in neuroblastoma, we can modify the microarray to include such regions," he added. "We have customized this tool for neuroblastoma, but the appr...

Molecular Partners Required For Appropriate Neuronal Gene Repression

...ocess, Bebo and Sherman joined forces with Back, a pediatric neurologist and researcher studying developmental brain injury in premature infants. Previous research by Back and other scientists had revealed a link between the white matter brain damage associated with premature birth and damage to immature cells...

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