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Tag: "pathway" at biology news

Scientists uncover new clues about brain function in human behavior

...udy to identify functional disturbances in a brain pathway associated with abnormal social behavior caused by a genetic disorder," said NIMH Director Thomas R. Insel, M.D. In this study, investigators used functional brain imaging (fMRI) to study the amygdala and structures linked to it in 13 participants w...

Opiate cocktail may spare cells from morphine's dark side

...pensatory overactivation of a particular signaling pathway in the cell--a signaling imbalance that is a hallmark of opiate tolerance and dependence. This suggests that the promotion of MOP-receptor internalization might prevent such cellular signaling imbalances, and indeed past work from Whistler indicated ...

Genomatix, AAAS ink agreement

...wledge Environment into Genomatix's BibliospherePE pathway knowledge base and analysis system. AAAS, publis...pathways. Genomatix developed the BibliospherePE pathway knowledge base and analysis system. It allows for dynamic data-driven network/pathway construction a...

Trio of plant genes prevent 'too many mouths'

A signaling pathway required for plants to grow to their normal size a...ntists already believed that part of the signaling pathway for stomata production included the receptor-like protein Too Many Mouths, so called because when ab...

Virus uses tiny RNA to evade the immune system

...echanism, "it became clear that such a fundamental pathway could of course be pirated by a virus," said postdoctoral fellow Adam Grundhoff, co-first author of the paper. Thomas Tuschl, a newly selected HHMI investigator at The Rockefeller University, had already reported the existence of several microRNAs e...

Breast tumors in mice eradicated using cancer vaccine

...stroyed in the vacuole that feeds the MHC class II pathway of antigen presentation with the induction of help.... This is important because the antigen-processing pathway that feeds antigenic peptides to the surface of the cell for recognition by killer T cells is genera...

Study: Plants use dual defense system to fight pathogens

...-associated molecular patterns, or PAMPs. The PAMP pathway appears to be a plant's first line of defense agai...tricting the growth of many pathogens." The other pathway uses disease-resistant proteins, or R-proteins, which can detect certain molecules, called effectors...

Eleven gene 'signature' reliably predicts cancer prognosis

... of the conserved BMI-1-associated gene expression pathway that exists in a very malignant subset of human cancers predicts a marked predisposition toward metastasis and a high probability of poor therapy outcome. In an accompanying commentary, Gordon Mills and others write, "such a "magic marker" [will] hav...

Firefly protein lets researchers monitor molecule linked to cancer

...hain reactions known as the NF-KappaB pathway. The pathway can start at many different receptors on cell surf...t the potential reaction patterns in the NF-KappaB pathway form an hourglass-like shape, fanning out among many options at the start, narrowing in the middle, ...

New study finds how cells with damaged DNA alert the immune system

...ent of a cell's genetic material -- the DNA damage pathway -- was exposure to radiation and chemotherapy drugs. They found that cells in which the DNA damage pathway was triggered were the ones that exhibited an increase in the expression of special proteins on the ...

Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases

...ruses. "We believe that interfering with the Rab9 pathway interferes with the ability of the viruses to exit...ggests that Rab9 and other components of this exit pathway might be attractive targets for antiviral therapies for a variety of viruses. Blocking Rab9 may hav...

Renewed hope for Parkinson's patients

...ent of a cell's genetic material -- the DNA damage pathway -- was exposure to radiation and chemotherapy drugs. They found that cells in which the DNA damage pathway was triggered were the ones that exhibited an increase in the expression of special proteins on the ...

Eliminating bacterial infections out of thin air

...how for the first time that induction of the HIF-1 pathway can act as a "super-antibiotic", accelerating the killing of bacteria in conditions typical of those found during bacterial infection and sepsis. The authors show that regulation of HIF-1 is required for immune defense against bacterial infection. T...

Clean skies=faster global warming?

...how for the first time that induction of the HIF-1 pathway can act as a "super-antibiotic", accelerating the killing of bacteria in conditions typical of those found during bacterial infection and sepsis. The authors show that regulation of HIF-1 is required for immune defense against bacterial infection. T...

Out of sight, out of mind? Not necessarily

...arly Edition, suggests the brain has more than one pathway along which visual information can be sent. For t...l or a vertical line; because their primary visual pathway had been shut down, the participants reported that they saw nothing. However, when forced to guess ...

Does manganese inhaled from the shower represent a public health threat?

...r. "The nerve cells involved in smell are a direct pathway for toxins to enter the brain. Once inside these s...latory agencies have not considered this potential pathway when setting drinking water standards. "Studies should be carried out among populations that have e...

Tissue regeneration operates differently than expected

...stem cells are recruiting the IL-4/NFAT signalling pathway which also is involved in the activation of T-lymphocytes during immune response. From the findings presented by Thomas Braun and his collaborators some important consequences for the use of adult stem cells in possible therapeutic approaches could ...

Purdue researchers find key to rice blast fungus

...ungus genome in the April 21 issue of Nature. This pathway is the communications highway that passes informat...n't develop appressoria and infect the plant. The pathway holds enormous potential of being used to produce new fungicides or new resistant rice plants to hol...

Discovery that bacterium is phosphate gourmet key clue to what makes it most social of bacteria

...a only required one phosphate dependent signalling pathway to find the phosphate needed for consumption, and ...ng all three pathways and part of a further fourth pathway in combination, to detect and utilise phosphates, making it a very sophisticated consumer of phospha...

An essential regulator of body weight revealed

...t to feeding; meanwhile, the importance of the NPY pathway diminished. To some extent, the field began to think these cells were supporting players, but not really important," said Palmiter. Now, however, Palmiter's lab has taken a different approach, and demonstrated definitively that NPY/AgRP neurons are ...

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