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Tag: "pathway" at biology news

A new mechanism of regulating RNA degradation

...dical Center, and her team have identified a novel pathway for RNA degradation, a form of regulation that has...ty and the life span of the RNA itself. One major pathway for such post-transcriptional regulation is called nonsense-mediated decay (NMD). Originally NMD was...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...dical Center, and her team have identified a novel pathway for RNA degradation, a form of regulation that has...ty and the life span of the RNA itself. One major pathway for such post-transcriptional regulation is called nonsense-mediated decay (NMD). Originally NMD was...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...ced DNA repair capacity in the nucleotide excision pathway that fixes DNA alterations known as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia University Mailman School of Public Health in New York, and colleagues analyzed cell lines generated from blood sa...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...somal sialic acidtransporter.Varki noted that this pathway is an unusual and previously unknown onethat may also be relevant to the entry of other small molecules intocells. In addition, the JBC study showed how Neu5Gc attached to dietaryproteins from animals could be incorporated into cells lining thestomac...

Plants, animals share molecular growth mechanisms

...x triggers communication between molecules along a pathway that leads to the creation of long protein strings...l The Plant Cell. "Perhaps by learning about this pathway for actin filament formation, we can engineer plant cells to grow in different ways or alter how cel...

Plants respond similarly to signals from friends, enemies

...on of the plant's cytoskeleton, which is part of a pathway that leads to a series of growth changes that include the formation of either nodules housing bacteria or giant cells from which the nematodes feed. The scientists also discovered that, like rhizobia and contrary to popular belief, the root-knot nem...

Bound for destruction: Ubiquitination protects against improper Notch signaling

The Notch pathway is an important molecular signaling mechanism whos...ses to permit or suppressactivation of a signaling pathway represents a neat solution to theproblem confronting cells of how to prevent molecular loose cannons...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

... actually a "missing enzyme" from the biosynthetic pathway for an agent used by the bacteria to scavenge iron...c was almost certainly a "missing enzyme" from the pathway for biosynthesis of the iron scavenging agent mycobactin," recalls Dr. Baker. "Mycobactin is a smal...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...he sequence in the worm, and both binding site and pathway for Ras are highly conserved. Tissue from lung cancer tumors, compared with their normal adjacent tissue, had reduced let-7 and increased Ras -- the brakes on Ras were removed in lung tumors. "The discovery of a new aspect of the regulation and tar...

Mouse brain tumors mimic those in human genetic disorder

...e to the brain.This type of tumor, called an optic pathway glioma, is the most commontumor in children with N...r to that seenin humans. Unlike most tumors, optic pathway gliomas associated withNF1 typically stop growing after a few years. Moreover, they almostalways occ...

A bacterial genome reveals new targets to combat infectious disease

... is the presence in the bacterium of the synthetic pathway for heme - the oxygen-carrying iron component of h...sis of developmental hormones, so Wolbachia's heme pathway may be an inviting target for therapy against nematode infection. Since no new antifilarial has been...

Scientists discover the cellular roots of graying hair

... much more refined way of dissectingthat signaling pathway in melanoma. Eventually we hope to tap into thisdeath pathway, thereby using drugs to mimic the aging process, tosuccessfully treat melanoma.?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradual...

Researchers identify target for cancer drugs

...ing to fully understand a particular communication pathway inside of cells that contributes to many malignant brain and prostate cancers. While scientists have identified elements of this pathway, other key components have remained a mystery. Researchers at Whitehead Institute now have discovered a missing p...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

... much more refined way of dissectingthat signaling pathway in melanoma. Eventually we hope to tap into thisdeath pathway, thereby using drugs to mimic the aging process, tosuccessfully treat melanoma.?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradual...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

... much more refined way of dissectingthat signaling pathway in melanoma. Eventually we hope to tap into thisdeath pathway, thereby using drugs to mimic the aging process, tosuccessfully treat melanoma.?The team also made mice lacking a gene, MITF that regulates Bcl2. Thesemice also went gray, but more gradual...

U-M scientists find genes that control growth of common skin cancer

... locations,such as the face.The Hedgehog signaling pathway plays a key role in normal development,and its dys... in which they couldmanipulate expression of an Hh pathway component, called Gli2 ,effectively turning it on or off at will in the skin. As expected,expression...

Studies reveal methods viruses use to sidestep immune system

...n spend our time completely defining the signaling pathway that goes from RIG-I all the way down to IRF-3," D... we've done that, we hope to identify parts of the pathway to target with drugs to try to limit infection." Drugs called protease inhibitors currently are use...

MSI releases 'moleculizer' - a new approach to simulation of intracellular biochemical networks

...ackof the thousands of complex species formed from pathway proteins as itsimulates reactions between them by ...stand thequantitative behavior of a cell signaling pathway in yeast. The AlphaProject is funded by the National Institutes of Health's National HumanGenome Res...

PANTHER Protein Classification System Database 5.0

...,which provides sufficient molecular detail of the pathway data forsystems biology applications. “We've gaine...ifies the task of capturing anddisplaying detailed pathway data,?added Dr. Thomas.“This collaboration has been a terrific experience that has provided uswith e...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

...y,drugs that target different molecules along that pathway may beespecially effective for treating the diseas... AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe th...

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