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Tag: "pathology" at biology news

Agent slows aging in mice

... in three laboratories,” says Miller, professor of pathology at the U-M Medical School and associate director of the U-M Geriatrics Center. Miller is also a research scientist at the Ann Arbor VA Medical Center. No significant difference occurred in female mice. The scientists can’t explain why at this poin...

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

... cent increase in skin cancer samples processed by pathology laboratories. The figures also showed that the three most common skin cancers - basal cell carcinoma, squamous cell carcinoma and malignant melanoma - accounted for 27 per cent of all male cancers and 26 per cent of all female cancers. “These ...

Study finds mix of disease processes at work in brains of most people with dementia

...nteers who died had sufficient Alzheimer’s disease pathology in their brains to fulfill accepted neuropathologi...ase. “We know that people can have Alzheimer’s pathology without having symptoms,” says Dallas Anderson, Ph.D., population studies program director in the NI...

How 'memory' T cells curb the spread of viruses throughout the body

..., and his Fox Chase colleagues in the virology and pathology programs, provides the basis whereby memory CD8 T cells do, in fact, prevent viral diseases. CD8 T cells normally reside in lymphoid organs such as the lymph nodes. It was thought that to protect from disease, memory CD8 T cells needed first to mu...

Modified mushrooms may yield human drugs

...ayne Chair in spawn science and professor of plant pathology at Penn State. "Mushrooms could make the ideal vehicle for the manufacture of biopharmaceuticals to treat a broad array of human illnesses. But nobody has been able to come up with a feasible way of doing that." Dr. Romaine and his colleague, ...

How to steer a moving cell

...t the body. Richard Klemke, Ph.D., professor of pathology at UCSD School of Medicine and the Moores Cancer Center, and his colleagues set out to better understand the complexity of signaling mechanisms within the cell that become de-regulated and allow cells which are usually static to begin migrating. ...

Molecule that destroys bone also protects it, new research shows

...e molecules that contribute to host defense versus pathology is very important for gaining a fundamental understanding of the immune system," Gaffen said, "but also because the consequences of therapies that target these cytokines need to be understood." ...

Scientists develope a new model of artificial canine skin

...ious lines of research related to skin biology and pathology without the need to use live animals. The basic structure of skin consists of an external layer, the epidermis, and an internal layer, the dermis, separated by a basal membrane. A study of the interactions between the cell populations of the various...

Link found between immune system and high plasma lipid levels

...e laboratory of Yang-Xin Fu, MD, PhD, professor of pathology at the University of Chicago—suggest that an engineered protein could keep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for coronary heart disease. "Besides showing a link between the immun...

Microbes start immune response by sneaking inside cells

...iel Nunez, M.D., the Paul H. de Kruif professor of pathology at the U-M Medical School and a member of the U-M Comprehensive Cancer Center. For years, scientists have believed that when bacteria invade the body, they set off alarms in the immune system by interacting with receptors on a cell’s surface. But,...

Why doesn't the immune system attack the small intestine?

...ates Turley, who is also an assistant professor of pathology at Harvard Medical School. "But it has been unclear how dendritic cells, which are extremely sensitive to microbial agents such as bacteria, teach T cells to resist attacking healthy intestinal cells." In the new study, Turley and her colleagues fo...

New cell type identified in cancer development

...r. Jian-Xin Gao, a researcher in the department of pathology at Ohio State University Medical Center, has identified a new set of cells he calls precancerous stem cells (pCSCs). These cells share some of the characteristics full-fledged cancer stem cells have, but they are different in that they respond to ...

New study may show how to forestall a fatal, virus-caused immune-system meltdown

...Hong Zhang and Barry Elsom, associate professor of pathology Judith Aronson, biochemistry and molecular biology instructor Heidi Spratt, and biochemistry and molecular biology professors David Gorenstein and Bruce Luxon. Funding for the investigation was provided by the Defense Advanced Research Projects Agenc...

How genetic malfunction causes a form of retardation

...w the genetic abnormality gives rise to the neural pathology of the disorder. More broadly, they said, the new insight into the mechanism underlying NS could apply to other inherited forms of retardation. Freda Miller of the Hospital for Sick Children and University of Toronto and colleagues published their f...

Gene expression test reveals ER and HER-2 status of breast tumors

.... The status of these factors is now determined by pathology tests. "This is one important step towards pers...s them comparable to, if not better than, existing pathology tests. "This moves us closer to developing an integrated single genomic test that could estimat...

Researchers discover surprising drug that blocks malaria

...nd Emma H. Morrison Professor in the department of pathology at the Feinberg School of Medicine at Northwestern. Sean Murphy, a Medical Sciences Training Program student, is the study's lead author. The study was published in PLoS Medicine. Malaria, one of the top three deadliest diseases in the develop...

Napoleon's mysterious death unmasked, UT Southwestern researcher says

...pean history," said Dr. Robert Genta, professor of pathology and internal medicine at UT Southwestern and senio...-of-the-art tumor-staging method from 21st century pathology and determined that Napoleon had at least T3N1M0, or Stage IIIA, gastric cancer, which is very sever...

UCLA scientists design masks to hide genetic mutations from cell

.... AUTHORS: Dr. Richard Gatti, professor of pathology and human genetics, and postdoctoral fellow Liutao Du at the David Geffen School of Medicine at UCLA, are available for interviews. JOURNAL: The research appears in the March 19 online edition of the Proceedings of the National Academy of Scienc...

Antibody signal may redirect inflammation to fuel cancer

... to attack," said Coussens, associate professor of pathology in the UCSF Cancer Research Institute. "But in precancerous tissue in mice, we have found that leukocytes apparently receive signals to switch programs, stimulating cell growth and increasing blood supply -- processes that would normally help healing...

Statin plus cancer drug deliver combo punch to brain cancer cells

...dled and tumor cells died off. Lead author and pathology fellow Eli E. Bar, Ph.D., said he was "surprised by the degree to which the drug combination was so effective." According to Eberhart, only half of children with medulloblastoma survive. "And those that do survive can suffer debilitating side eff...

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