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Tag: "pathological" at biology news

Building a human kinase gene repository

... their deregulation is associated with a number of pathological conditions, which make kinases key targets in drug discovery efforts, primarily in oncology. This collection is unique because clones in the collection represent protein kinases as well as non-protein kinases, are fully sequenced verified, full-leng...

Important discovery about second most fatal cancer

...syndrome is characterized by distinctive clinical, pathological and molecular features: # Early age at onset # More common in females # More common in right side of colon # Little evidence of tumour immunity # Frequent mutation of an oncogene called BRAF (also mutated in cancer of thyroid, ovary, and melanoma) #...

Scientists discover that three molecules may be developed into new Alzheimer's drugs

...ormally in the brain. "Tau goes wrong and becomes pathological when it becomes intensely phosphorylated," said Kosik. "This means that many phosphate groups attach to tau--modify it--and cause it to become dysfunctional." The culprit is an enzyme, called CDK5, that attaches the phosphate to the tau protein, fac...

Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

...ormally in the brain. "Tau goes wrong and becomes pathological when it becomes intensely phosphorylated," said Kosik. "This means that many phosphate groups attach to tau--modify it--and cause it to become dysfunctional." The culprit is an enzyme, called CDK5, that attaches the phosphate to the tau protein, fac...

Pinpointing the cause of a neurodegenerative disorder

...earchers then showed that the same interaction and pathological effects occurred in mice -- in which Ataxin-1 affected the mammalian version of Senseless, which is called GFi-1. And, they found that mice lacking GFi-1 showed Purkinje cell degeneration, just like humans with SCA1. "The overall picture we have now...

Measuring hidden parasites in falciparum malaria

...mature forms of the parasite is the most important pathological process in falciparum malaria. Approximately 40% of the world's population, mostly living in the world's poorest countries, is at risk of malaria. In the tropical and subtropical regions of the world, malaria causes 300 million acute illnesses and ...

Gambling monkeys give insight into neural machinery of risk

...uch neurotransmitter systems might be the basis of pathological conditions like pathological gambling, obsessive-compulsive disorder and depression. We can do pharmacological manipulation of th...

Computer modeling reveals hidden conversations within cells

...rd developing drugs that interfere with one of the pathological functions of the proteins, but leave the healthy functions intact. For example, many current cancer drugs dramatically reduce immune function. Computer modeling should make it possible to design anti-cancer drugs that do not weaken patients' immune...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

...mmune cells (such as macrophages) as well as other pathological changes in the transplanted heart tissue that indicate the graft is being rejected by the body's immune system. These procedures are costly, uncomfortable and must be repeated annually for a few years to monitor and treat any rejection. Biopsies als...

Sea coral's trick helps scientists tag proteins

...tion during embryogenesis, inflammation, and other pathological and normal processes," he said. Unlike other green-to-red fluorescent markers, Dendra can be activated by visible blue light, which is less harmful to living cells and does not require special laser equipment, Konstantin Lukyanov explained. In fact,...

Animal brains 'hard-wired' to recognize predator's foot movements, Queen's study suggests

...Snakes, insects and spiders, or birds can generate pathological reactions not observed in response to 'normal' animals." ...

Neuroscientists discover new cell type that may help brain maintain memories of smells

...olfactory brain, we might find a novel window into pathological changes that affect memory in people with Alzheimer's disease," said Strowbridge. In addition to leveraging the olfactory system to better understand Alzheimer's disease, Pressler is excited about the prospect of unraveling the patterns of synapti...

Retinol for combating leukemia cells

... cells: necrosis and apoptosis. Necrosis defines a pathological death, i.e. a death caused by a lack or deficit within the cell such as lack of oxygen or food. On the other hand, apoptosis is the pre-programmed death of a cell. A number of cells have to die in order that our organism function correctly: for exa...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

...d angiogenic factor that plays a prominent role in pathological angiogenesis both through direct tumor cell expression of SCF and by normal neurons that are damaged by the growing tumor. The researchers point out that the clinical significance of these findings extends beyond identification of SCF as a rational t...

Experimental drug reverses key cognitive deficits, pathology in Alzheimer's

...ing and memory deficits in mice engineered to have pathological hallmarks of the disease. What's more, the drug, c... that treatment with AF267B reduced levels of both pathological plaques and tangles in the cortex and hippocampus, but not in the amygdala. In experiments that dem...

Researches discover gene critical for protection against septic-shock-induced death

...ptic shock. Secondly, Nrf2 protects from oxidative pathological damage, the main cause of multi-organ failure duri...tion of Nrf2 by a small-molecule drug can minimize pathological damage and improve survival during sepsis caused by bacteria or viruses. Future studies will determi...

In a technical tour de force, Salk scientists take a global view of the epigenome

...a cell's DNA methylation pattern - be it normal or pathological - is established, methylated sites are faithfully inherited by daughter cells. The ability to take a high-resolution snapshot of what genes are methylated and which ones aren't during different developmental or disease states might show how cells sel...

Speeding discovery of the 'human cancer genome'

...tood." Lowe's team relied on mice with specific pathological changes known to play a role in some liver cancers. They then searched for other spontaneous mutations in the animals' tumors and compared them to recurrent alterations observed in the human disease. That comparison narrowed the field to two genes...

Parkinson's disease mechanism discovered

...etermine which abnormalities arose earliest in the pathological process. Those experiments by Cooper revealed that an important early defect affected the machinery that transports proteins between two major cellular organelles -- the endoplasmic reticulum (ER) and the Golgi apparatus. The endoplasmic reticulum is...

First study to show how immune cells 'speak' to each other in vivo

... immunological synaptic function during normal and pathological immune responses in vivo. The full study can be accessed at www.jem.org . WHY: The mechanism of how immunological synapses "speak" to each other in vivo has not been observed prior to this research. Although formal proof of this awaits the ...

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