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Tag: "paradigm" at biology news

'Prosthetic' retinal cells let blind mice see light

..."With this strategy, the investigators have made a paradigm shift in the field and opened the possibility of genetically modifying the surviving retinal interneurons to function as a replacement light-sensing receptor," wrote John Flannery and Kenneth Greenberg in a preview of the paper in the same issue of N...

FDA approves first medical device using rutgers biomaterial

...developed at the university. This action signals a paradigm shift in the application of biomaterials from permanent prosthetic replacements toward regenerative medicine, in which materials help the body to repair itself and are then resorbed. The device consists of a surgical mesh coated with a polymer deve...

Liquid crystals show promise in controlling embryonic stem cells

...is newly devised cell culture system enables a new paradigm in stem cell research," says chemical and biological engineer and MRSEC Director Juan de Pablo. "Ultimately, we hope to use liquid crystalline materials to transmit desired sets of physical and chemical cues to stem cells so as to control their diffe...

Tandem transcripts team together

...tic genome, a picture emerges that challenges this paradigm ?not a picture in which the sequences in the genome have distinct functions, but rather one in which the sequences participate in multiple transcripts, encoding molecules with diverse functionality." Sorek's team systematically identified over 200 c...

Bone and cartilage growth to blame for heart valve disease

...ering a Northwestern researcher's effort to lead a paradigm shift in the medical community's beliefs about the cause of valve disease. Heart valve disease is caused not by a 'wear and tear' phenomenon, but by an inflammatory process likely triggered by high cholesterol that stimulates certain cells to reprog...

Measuring artery repair cells could become new heart disease test

...ts a novel approach to solving this problem. "The paradigm of atherosclerosis is changing. In the past we only thought of the risk factors we could measure, such as cholesterol, lipids and some new markers like c-reactive protein," Povsic continued. "We're learning that atherosclerosis is a balancing act bet...

Hyena mothers give their cubs a helpful dose of hormones

... Wolff believes that Holekamp's work will create a paradigm shift in how scientists view the establishment of dominance in mammals. ...

Research: Snails were overlooked contributors to marsh destruction

...gy, the message is even clearer: The long-standing paradigm that bottom-up forces rule is officially dead." Climate change aside, the study also falls in line with other recent studies highlighting the role of predators or other top-down animals. "This study adds to a growing body of evidence showing strong ...

Penicillin, amoxicillin: Step aside for strep throat treatment

...or of Microbiology and Immunology. "The treatment paradigm for treating strep sore throats has been changing slowly, and endorsing the use of cephalosporins as a first-line treatment is something that needs to be seriously considered," Pichichero said. While the newer short-course cephalosporins are only av...

War on terror meets war on cancer

...16, and rare hydrogen-2 to common hydrogen-1. The paradigm is that water diffuses so quickly into and out of cells that the water inside a cell is indistinguishable from water outside a cell," Hegg says. The researchers grew E. coli bacteria at body temperature in flasks containing a nutrient-rich liquid cu...

New factor implicated in allergy and asthma attacks

...hma attacks. Sur and Boldogh predict that this new paradigm of initiation of allergic inflammation will lead to extensive research into discovery of novel compounds that either specifically inhibit pollen NADPH oxidases or those that prevent or inhibit oxidative stress in the lungs induced by this enzyme. Pa...

A step toward the $1,000 personal genome using readily available lab equipment

... of the $1,000 human genome requires a significant paradigm shift in our underlying approach to the DNA polymer," write the Harvard scientists. The new technique calls for replicating thousands of DNA fragments attached to one-micron beads, allowing for high signal density in a small area that is still large...

Huntington's cure in flies lays groundwork for broader treatment approaches

...ts the growing need to embrace a broader treatment paradigm in the realm of genetic disorders, says Yin. In working with a disorder such as Fragile X Syndrome, for example, conventional therapies might focus all their efforts on repairing the genetic pathways that cause neurons to go awry. Meanwhile, "the de...

Novel mechanism for DNA replication discovered

...DNA by James Watson and Francis Crick in 1953, the paradigm for DNA replication has stated that the DNA itself codes for the appropriate pairings for replication. In other words, if a guanine base is on the original strand of DNA then its partner, a cytosine base, will pair to it on the replicated strand. In...

New type of rejection blocker protects kidneys after transplant

...live up to their promise, they will usher in a new paradigm for organ transplantation," Vincenti said. Instead of sending patients home with a collection of medications that must be taken daily to prevent rejection by suppressing the immune system's hostile response to a transplanted organ, Vincenti said he e...

'Punctuated' evolution in the human genome

...A duplications, and it challenges the evolutionary paradigm that continuous alterations occur during the course of genome evolution. The scientists, who are affiliated with the University of Washington (Seattle, WA), Case Western Reserve University (Cleveland, OH), the University of Bari (Bari, Italy), Washi...

Newest HIV drugs should be used with FUZEON(R)

...x studies, in over 2,500 patients, establish a new paradigm in the management of triple class-experienced patients. Why FUZEON is effective in face of HIV resistance FUZEON is still the first and only anti-retroviral drug to work outside the human immune cell (CD4), blocking the HIV virus from entering. All...

Supercomputer Dedicated To Bioengineering, Computational Biology Installed

...d bioengineers across the country as part of a new paradigm often referred to as grid computing. The new cluster, which was purchased from Dell for less than $180,000 per Teraflops (trillion floating point operations per second), is a distributed-memory parallel computer. It is valued not only for its speed,...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

...rove human health, we need to shift the healthcare paradigm from diagnosing and treating existing diseases, to being able to predicting disease susceptibility and an individual's response to drugs," said Patrick Kelly, European Site Manager and Vice President, Affymetrix. "This is what personalized medicine i...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...tiation of tumor formation. This study sets a new paradigm for gastrointestinal tumorigenesis, in that genetic events outside the epithelial layer itself have a profound effect on tumor initiation. Thus it appears likely that this study will foster additional research into other mesenchymal genetic modifiers...

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