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Tag: "pancreas" at biology news

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

... humans," Dr. Patti said. In type 1 diabetes, the pancreas cannot make the hormone insulin at all; about 1 mi...affecting an estimated 18 million Americans -- the pancreas doesn't make enough insulin or the body's cells develop a resistance to its effect. Without insulin,...

U-M scientists find genes that control growth of common skin cancer

... skin and cancers arising inbrain, lung, prostate, pancreas and other gastrointestinal organs.Dlugosz and colleagues focused on the function of uncontrolled Hhpathway signaling in the growth of BCC.The investigators used genetically engineered mice in which they couldmanipulate expression of an Hh pathway com...

Chemists identify key gene in development of type 1 diabetes

...ogical events that leads to the destruction of the pancreas and the subsequent onset of type 1 diabetes. The disease is much less common than type 2 diabetes, formerly known as adult onset or non-insulin-dependent diabetes, which is often associated with obesity. "We've shown that the MIF gene is crucial for...

Towards precise classification of cancers based on robust gene functional expression profiles

...ogical events that leads to the destruction of the pancreas and the subsequent onset of type 1 diabetes. The disease is much less common than type 2 diabetes, formerly known as adult onset or non-insulin-dependent diabetes, which is often associated with obesity. "We've shown that the MIF gene is crucial for...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

... injured from cold storage, transport time and the pancreas is severely damaged by toxins which circulate in the blood stream after brain death." "Our expectation is that these islets from near-perfect organs will work better, although it's too early to tell," he says. The recipients use the same drugs to p...

Rare surgery performed to remove pancreas, prevent diabetes

...oducing cells to him after surgically removing his pancreas to eliminate constant, severe pain from chronic pa...room at UAB Hospital through removal of his entire pancreas and the hours-long wait for the pancreatic islet cells to be processed in a specialized UAB laborato...

Genetic defects give the immune system the green light to attack the pancreas

...n defective, allow the immune system to attack the pancreas ?the first in a series of mis-steps that lead to t...on’t learn this tolerance, they can infiltrate the pancreas and attack the insulin-producing beta cells.?This first step in the onset of type 1 diabetes is call...

Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes

...received islet transplantation from a single donor pancreas were insulin independent one year later, according...eved with a single donor, as is also the case with pancreas transplants, to reduce the risks and costs and increase the availability of islet transplantation. ...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

... days, and it takes every bit of that time for the pancreas to fully develop," Hammerman explains. "There is no pancreas before embryonic day 28, and 35-day-old pancreas is still very early-stage tissue." Hammerman and R...

Second messenger NAADP shows fast, dose-related impact on satiety cycle

...at tells cells to release digestive enzymes in the pancreas and to cause satiety in the brain. "The more cholecystokinin that's produced, the more digestive enzymes are released and the more quickly your brain tells you that you're full ?or at least satisfied. Indeed, it also could be a potential drug for the...

Attacks of King George III's madness linked to key metabolism molecule

...hyria, they add, occurs because glucose causes the pancreas to make more insulin, which results in suppression of the PGC-1 alpha gene. The findings suggest that patients with porphyria should avoid any drugs or foods that turn on PGC-1 alpha activity in the liver, the researchers say. There could be implica...

Insulin pulses keep the liver lean

...ic, said the researchers. Insulin produced by the pancreas allows cells to take up glucose from the bloodstre...nd heart disease, Najjar added. "When we eat, the pancreas produces insulin, which stimulates the absorption of sugar and fat by the liver," Najjar said. "But ...

Researchers devise new technique for creating human stem cells

...that can be used to rejuvenate organs, such as the pancreas or heart, that are damaged by disease or trauma. Stem cells also provide a model system in which researchers can study the causes of genetic disease and the basis of embryonic development. Eggan, Melton and their colleagues decided to pursue their a...

Malfunctioning bone marrow cells sabotage nerve cells in diabetes

...re among a group of cells in organs other than the pancreas that unexpectedly produced small amounts of insulin. In pursuing that finding, he and his colleagues found that the bone marrow cells that produced insulin adversely affected nerve cells or neurons. "In our latest studies, we were surprised to disc...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

...ruction of the insulin-producing beta cells of the pancreas has already progressed significantly. Recent pro... called T lymphocytes infiltrate the islets of the pancreas (an inflammatory condition known as insulitis), causing the blood vessels to become leaky. Over time...

Life-extending protein keeps blood sugar in check

...ith an excess of the protein Sirt1 in cells of the pancreas have improved glucose tolerance and enhanced insul...f insulin, Imai explained. Insulin produced by the pancreas allows cells to take up glucose from the bloodstream and burn it for energy. A failure to make or re...

Sea Ice May Be on Increase in the Antarctic

...ith an excess of the protein Sirt1 in cells of the pancreas have improved glucose tolerance and enhanced insul...f insulin, Imai explained. Insulin produced by the pancreas allows cells to take up glucose from the bloodstream and burn it for energy. A failure to make or re...

Scientists closer to new cancer detection method

...s with malignancies of the ovaries, kidneys, lung, pancreas and brain. After the probe physically conforms to the PDGF, the molecule can be snapped on like a light switch to flash a fluorescent signal. Tan, the associate director of UF's Center for Research at the Bio/Nano Interface, is seeking to patent th...

Embryonic stem cells accrue genetic changes

... in the body, in theory they could replace certain pancreas cells in people with type I diabetes, or regenerate brain cells lost in a person with Parkinson's disease, for example. The analyses of the embryonic stem cell lines and the computer comparisons of the mounds of resulting data required the efforts ...

Researchers reverse juvenile diabetes in animal model

...itic cells into the abdominal/pelvic area near the pancreas and lymph nodes, blocks the T cells as they travel to the pancreas to destroy beta cells. "We did this in mice, giving them six injections over the course of several...

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