Tiny RNA molecules fine-tune the brain's synapses
...ed neurotrophic factor (BDNF), this inhibition was overcome and Limk1 became active again, enhancing spine growth. Greenberg believes that miR-134 ?and other microRNAs his lab is studying ?may play a role in fine-tuning cognitive function by selectively controlling synapse development in response to environm...Neuroscientists discover new cell type that may help brain maintain memories of smells
...of imaging method called multiphoton microscopy to overcome these hurdles and to discover that Blanes cells talk to granule cells. "The multiphoton microscope allowed me to identify the axon and then follow it for long distances without damaging the Blanes cell. Once I could follow the axon as it coursed ...Genomics-based vaccine could prevent deadly cattle disease
...e importance of strategic research partnerships to overcome this and similar diseases. ...Penguins waddle but they don't fall down, UH researchers say
...ns waddle too much they fall, but penguins somehow overcome this. They may have an elegant movement strategy for stability that we're unaware of." Kurz hopes that learning about the penguin's distinctive waddle will help those with walking challenges, such as the elderly, those with leg or foot injuries an...St. Jude projects 90 percent cure rate for ALL
...the breakthroughs of past decades and successfully overcome the remaining challenges." The dramatic increase in cure rates for children is especially significant in the case of African-American children, Pui noted. They still have poor outcomes in national studies, but studies at St. Jude have shown African...Morning grogginess more debilitating than sleep deprivation, according to CU-Boulder study
...r example, motivation alone may be insufficient to overcome the effects of sleep inertia," he said. The paid study volunteers, nine of whom were included in the sleep inertia study, slept eight hours per night during the month leading up to the study, had no medical, psychiatric or sleep disorders and were ...Do plants have the potential to vaccinate against HIV?
...archers at the University of Warwick say they have overcome a major barrier that has so far frustrated attempts to turn plants into economically viable "bioreactors" for vaccines. By creating fusion molecules, the researchers have found a way to make plants produce more of the molecules (antigens) needed for...U of S researchers develop new vaccine candidate against hepatitis C
...y." About 20 per cent of people who contract HCV overcome the virus on their own. For those who develop chronic hepatitis, the immune system cannot clear the infection. "In patients with chronic hepatitis C, there is evidence that the function of their dendritic cells is altered," said Sylvia van den Hurk,...Molecular mechanism may explain how fevers spark seizures
... can in principle design therapeutic strategies to overcome it." ...A large step forward in the fight against African sleeping sickness
...esiense. This truncated ApoL-1 variant can help to overcome the parasite that infects our body, but only when it is present in very high concentrations. The challenge for the researchers was to get this truncated ApoL-1 variant efficiently to the place where it is needed: onto the surface of the parasite. N...Ancient fossil DNA found preserved in crystal
...uross, Harvard University, may have found a way to overcome these problems. It was in 1986 that Weiner first reported the existence of crystal clusters in fresh bones. Even when these bones are ground up and treated with sodium hypochlorite ?a substance that removes all traces of organic matter ?the cluster...HIV vaccine takes different tack to boosting immune response
...ugh. So by relieving the 'brake,' we can hopefully overcome what is failing in the natural anti-HIV immune response." In the study, funded by the National Institutes of Health, Chen and colleagues examined a molecule, SOCS1, which regulates how antigens are handled by dendritic cells, specialized white blood...VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum
...ed a new platinum-based, anti-cancer agent able to overcome acquired drug resistance by first modifying the wa...eutic agent." "Our novel compound was designed to overcome resistance by emphasizing new modes of DNA binding, and in the process we have found that the amount...A step forward in the fight against bacterial infections
...gainst infections Most of the time, our body can overcome bacterial infections. Only a limited number of bacteria can make us sick, but sometimes they can be fatal. In the US, about 200,000 people die from bacterial infections each year. Normally, our natural immune system bars bacteria from entering our bo...Nanopore method could revolutionize genome sequencing
...esearchers caution that there are still hurdles to overcome because no one has yet made a nanopore with the required configuration of electrodes, but they think it is only a matter of time before someone successfully assembles the device. The nanopore and the electrodes have been made separately, and althoug...Genetically altered mice no longer like cocaine
...chieve the same results and therefore help addicts overcome their dependence. Right now there are no such treatments on the market, said Howard Gu, the study's lead author and an associate professor of pharmacology and psychiatry at Ohio State University . The study confirms that the dopamine transporter ?a...Researchers find molecular 'brake' to cell death
...d to release a large and sustained volume of CC to overcome this nucleotide barrier, and they also found evidence that as soon as the release of CC increases, another mechanism kicks in that simultaneously begins to reduce the size of the nucleotide pool to allow CC to bind to Apaf-1, Tang says. The research...Everything in its place: Researchers identify brain cells used to categorize images
...gnizes and recalls visual information will help us overcome impairments to these functions caused from brain damage and diseases, including strokes, Alzheimer's disease, and schizophrenia," Freedman says....Buckyballs boost antibody's chemotherapy payload
...e team from Rice and M. D. Anderson had planned to overcome this limitation by attaching multiple molecules of Taxol to each buckyball, which would then be covalently connected to the antibodies. To the team's surprise, many more buckyballs than expected attached themselves to the antibody. Moreover, no coval...Five surprising facts about starvation that could change the international agenda
...arency are not in themselves sufficient factors to overcome the persistence of wasting in marginalized vulnerable groups." Wasting is a complex condition that is not simply caused by conflict or famine alone. Gross and Webb conclude that "effective, targeted actions are needed as part of the development agend...